CDH13 gene coding t-cadherin influences variations in plasma adiponectin levels in the Japanese population
Article first published online: 8 DEC 2011
© 2011 Wiley Periodicals, Inc.
Volume 33, Issue 2, pages 402–410, February 2012
How to Cite
Morisaki, H., Yamanaka, I., Iwai, N., Miyamoto, Y., Kokubo, Y., Okamura, T., Okayama, A. and Morisaki, T. (2012), CDH13 gene coding t-cadherin influences variations in plasma adiponectin levels in the Japanese population. Hum. Mutat., 33: 402–410. doi: 10.1002/humu.21652
- Issue published online: 12 JAN 2012
- Article first published online: 8 DEC 2011
- Accepted manuscript online: 7 NOV 2011 10:11AM EST
- Manuscript Accepted: 24 OCT 2011
- Manuscript Received: 13 MAY 2011
Adiponectin is most abundantly expressed in adipose tissue and well known to play an important role in metabolic regulation. Several studies have attempted to identify the genetic determinants of metabolic syndrome (MetS), though no study has revealed a cis- or trans-single nucleotide polymorphism (SNP) that affects plasma adiponectin levels, except the adiponectin structure gene and genes encoding adiponectin-regulatory proteins. We performed a genome-wide association study in regards to plasma adiponectin concentrations in 3,310 Japanese subjects. We identified the strongest statistically associated SNP (rs4783244) with adiponectin levels (P = 3.8 × 10−19) in the first intron of CDH13 (T-cadherin) gene in a 30-kb haplotype block covering the promoter region to first intron. In addition, rs12051272 SNP genotypes in linkage disequilibrium with rs4783244 were found to be more significantly associated with adiponectin levels (P = 9.5×10−20) and specifically with the levels of high-molecular weight (HMW) adiponectin, a subtype form associated with parameters related to glucose metabolism. Our results did show more significant association with adiponectin levels than rs12444338 (in CDH13) SNP genotypes reported recently. We suggest that the phenotype-affecting haplotype tagged by rs12051272 SNP would affect the plasma adiponectin levels and that we have to take the CDH13 genotype into account before considering the functional relevance of the adiponectin level. Hum Mutat 33:402–410, 2012. © 2011 Wiley Periodicals, Inc.