Database in Brief

You have free access to this content

NGS catalog: A database of next generation sequencing studies in humans†

  1. Junfeng Xia1,
  2. Qingguo Wang1,‡,
  3. Peilin Jia1,
  4. Bing Wang1,
  5. William Pao2,3,
  6. Zhongming Zhao1,3,4,*

Article first published online: 19 APR 2012

DOI: 10.1002/humu.22096

Issue

Human Mutation

Human Mutation

Special Issue: Focus on CNV Detection with Diagnostic Arrays

Volume 33, Issue 6, pages E2341–E2355, June 2012

Additional Information

How to Cite

Xia, J., Wang, Q., Jia, P., Wang, B., Pao, W. and Zhao, Z. (2012), NGS catalog: A database of next generation sequencing studies in humans. Hum. Mutat., 33: E2341–E2355. doi: 10.1002/humu.22096

Author Information

  1. 1

    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA

  2. 2

    Department of Medicine/Division of Hematology-Oncology, Vanderbilt University School of Medicine, Nashville, TN, USA

  3. 3

    Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA

  4. 4

    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA

  1. ‡

    These authors contributed equally to this work.

*Department of Biomedical Informatics, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, Nashville, TN, 37203, USA. Phone: +1-615-343-9158; Fax: +1-615-936-8545.

  1. †

    Communicated by Johan T. den Dunnen

  2. ‡

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 7 MAY 2012
  2. Article first published online: 19 APR 2012
  3. Manuscript Received: 15 NOV 2011
  4. Manuscript Accepted: 9 MAR 2011

Funded by

  • Cancer-American Association for Cancer Research Innovative Research. Grant Number: SU2C-AACR-IRG0109
  • The VICC Cancer Center Core. Grant Number: P30CA68485

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (358K)

Keywords:

  • next generation sequencing (NGS);
  • exome sequencing;
  • whole genome sequencing;
  • RNA sequencing;
  • disease genome;
  • gene fusion;
  • database

Abstract

Next generation sequencing (NGS) technologies have been rapidly applied in biomedical and biological research since its advent only a few years ago, and they are expected to advance at an unprecedented pace in the following years. To provide the research community with a comprehensive NGS resource, we have developed the database Next Generation Sequencing Catalog (NGS Catalog, http://bioinfo.mc.vanderbilt.edu/NGS/index.html), a continually updated database that collects, curates and manages available human NGS data obtained from published literature. NGS Catalog deposits publication information of NGS studies and their mutation characteristics (SNVs, small insertions/deletions, copy number variations, and structural variants), as well as mutated genes and gene fusions detected by NGS. Other functions include user data upload, NGS general analysis pipelines, and NGS software. NGS Catalog is particularly useful for investigators who are new to NGS but would like to take advantage of these powerful technologies for their own research. Finally, based on the data deposited in NGS Catalog, we summarized features and findings from whole exome sequencing, whole genome sequencing, and transcriptome sequencing studies for human diseases or traits. © 2012 Wiley Periodicals, Inc. Hum Mutat 33:E2341–E2355, 2012. © 2012 Wiley Periodicals, Inc.

View Full Article with Supporting Information (HTML) Get PDF (358K)