These authors contributed equally to this work.
Database in Brief
NGS catalog: A database of next generation sequencing studies in humans†
Article first published online: 19 APR 2012
© 2012 Wiley Periodicals, Inc.
Special Issue: Focus on CNV Detection with Diagnostic Arrays
Volume 33, Issue 6, pages E2341–E2355, June 2012
How to Cite
Xia, J., Wang, Q., Jia, P., Wang, B., Pao, W. and Zhao, Z. (2012), NGS catalog: A database of next generation sequencing studies in humans. Hum. Mutat., 33: E2341–E2355. doi: 10.1002/humu.22096
Communicated by Johan T. den Dunnen
- Issue published online: 7 MAY 2012
- Article first published online: 19 APR 2012
- Manuscript Received: 15 NOV 2011
- Manuscript Accepted: 9 MAR 2011
- Cancer-American Association for Cancer Research Innovative Research. Grant Number: SU2C-AACR-IRG0109
- The VICC Cancer Center Core. Grant Number: P30CA68485
- next generation sequencing (NGS);
- exome sequencing;
- whole genome sequencing;
- RNA sequencing;
- disease genome;
- gene fusion;
Next generation sequencing (NGS) technologies have been rapidly applied in biomedical and biological research since its advent only a few years ago, and they are expected to advance at an unprecedented pace in the following years. To provide the research community with a comprehensive NGS resource, we have developed the database Next Generation Sequencing Catalog (NGS Catalog, http://bioinfo.mc.vanderbilt.edu/NGS/index.html), a continually updated database that collects, curates and manages available human NGS data obtained from published literature. NGS Catalog deposits publication information of NGS studies and their mutation characteristics (SNVs, small insertions/deletions, copy number variations, and structural variants), as well as mutated genes and gene fusions detected by NGS. Other functions include user data upload, NGS general analysis pipelines, and NGS software. NGS Catalog is particularly useful for investigators who are new to NGS but would like to take advantage of these powerful technologies for their own research. Finally, based on the data deposited in NGS Catalog, we summarized features and findings from whole exome sequencing, whole genome sequencing, and transcriptome sequencing studies for human diseases or traits. © 2012 Wiley Periodicals, Inc. Hum Mutat 33:E2341–E2355, 2012. © 2012 Wiley Periodicals, Inc.