Methods

Use of support vector machines for disease risk prediction in genome-wide association studies: Concerns and opportunities†

  1. Florian Mittag1,
  2. Finja Büchel1,
  3. Mohamad Saad2,3,
  4. Andreas Jahn1,
  5. Claudia Schulte4,
  6. Zoltan Bochdanovits5,
  7. Javier Simón-Sánchez5,
  8. Mike A. Nalls6,
  9. Margaux Keller6,7,
  10. Dena G. Hernandez6,8,
  11. J. Raphael Gibbs6,8,
  12. Suzanne Lesage9,11,12,
  13. Alexis Brice9,10,11,12,
  14. Peter Heutink5,
  15. Maria Martinez2,3,
  16. Nicholas W Wood8,
  17. John Hardy8,
  18. Andrew B. Singleton6,
  19. Andreas Zell1,
  20. Thomas Gasser4,
  21. Manu Sharma for the International Parkinson's Disease Genomics Consortium (IPDGC)4,*

Article first published online: 3 AUG 2012

DOI: 10.1002/humu.22161

Issue

Human Mutation

Human Mutation

Volume 33, Issue 12, pages 1708–1718, December 2012

Additional Information

How to Cite

Mittag, F., Büchel, F., Saad, M., Jahn, A., Schulte, C., Bochdanovits, Z., Simón-Sánchez, J., Nalls, M. A., Keller, M., Hernandez, D. G., Gibbs, J. R., Lesage, S., Brice, A., Heutink, P., Martinez, M., Wood, N. W., Hardy, J., Singleton, A. B., Zell, A., Gasser, T. and Sharma, M. (2012), Use of support vector machines for disease risk prediction in genome-wide association studies: Concerns and opportunities. Hum. Mutat., 33: 1708–1718. doi: 10.1002/humu.22161

Author Information

  1. 1

    Center for Bioinformatics Tuebingen (ZBIT), University of Tuebingen, Tübingen, Germany

  2. 2

    Institut National de la Sante et de la Recherche Medicale, UMR 1043, Centre de Physiopathologie de Toulouse-Purpan, Toulouse, France

  3. 3

    Département des Sciences du Vivant, Paul Sabatier University, Toulouse, France

  4. 4

    Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, and DZNE, German Centre for Neurodegenerative Diseases, Tübingen, Germany

  5. 5

    Department of Clinical Genetics, Section of Medical Genomics, VU University Medical Centre, Amsterdam, The Netherlands

  6. 6

    Laboratory of Neurogenetics. National Institute on Aging, National Institutes of Health, Bethesda, Maryland

  7. 7

    Department of Biological Anthropology. Temple University, Philadelphia, Pennsylvania

  8. 8

    Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK

  9. 9

    Université Pierre et Marie Curie-Paris, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, UMR-S975, Paris, France

  10. 10

    AP-HP, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Paris, France

  11. 11

    Institut National de la Sante et de la Recherche Medicale, UMR_S975 CRicm, Paris, France

  12. 12

    Centre National de la Recherche Scientifique, UMR 7225, Paris, France

*Hertie-Institute of Clinical Brain Research, Department of Neurology, University of Tuebingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany

  1. †

    Communicated by Christopher G. Mathew

Publication History

  1. Issue published online: 12 NOV 2012
  2. Article first published online: 3 AUG 2012
  3. Accepted manuscript online: 6 JUL 2012 10:06AM EST
  4. Manuscript Accepted: 18 JUN 2012
  5. Manuscript Received: 16 FEB 2012

Funded by

  • Intramural Research Programs of the National Institute on Aging; National Institute of Neurological Disorders and Stroke; National Institute of Environmental Health Sciences; National Human Genome Research Institute of the National Institutes of Health; Department of Health and Human Services (project numbers Z01-AG000949-02 and Z01-ES101986); Human subjects protocol 2003-077; US Department of Defense (award number W81XWH-09-2-0128); National Institutes of Health (grants NS057105 and RR024992); American Parkinson disease Association (APDA); Barnes Jewish Hospital Foundation; Greater St Louis Chapter of the APDA; Hersenstichting Nederland; Neuroscience Campus Amsterdam; the section of medical genomics, the Prinses Beatrix Fonds; and the Michael J. Fox foundation; the KORA (Cooperative Research in the Region of Augsburg) research platform was started and financed by the Forschungszentrum für Umwelt und Gesundheit, which is funded by the German Federal Ministry of Education, Science, Research, and Technology and by the State of Bavaria; German National Genome Network (NGFNplus number 01GS08134, German Ministry for Education and Research); German Federal Ministry of Education and Research (NGFN 01GR0468, PopGen); Initiative and Networking Fund of the Helmholtz Association (01EW0908 in the frame of ERA-NET NEURON); French National Agency of Research (ANR-08-MNP-012)

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