Research Article

Cancer Risks for MLH1 and MSH2 Mutation Carriers

  1. James G. Dowty1,*,
  2. Aung K. Win1,
  3. Daniel D. Buchanan2,
  4. Noralane M. Lindor3,
  5. Finlay A. Macrae4,
  6. Mark Clendenning2,
  7. Yoland C. Antill5,
  8. Stephen N. Thibodeau6,
  9. Graham Casey7,
  10. Steve Gallinger8,
  11. Loic Le Marchand9,
  12. Polly A. Newcomb10,
  13. Robert W. Haile7,
  14. Graeme P. Young11,
  15. Paul A. James12,
  16. Graham G. Giles13,
  17. Shanaka R. Gunawardena6,
  18. Barbara A. Leggett14,
  19. Michael Gattas15,
  20. Alex Boussioutas12,16,
  21. Dennis J. Ahnen17,
  22. John A. Baron18,
  23. Susan Parry19,
  24. Jack Goldblatt20,
  25. Joanne P. Young2,
  26. John L. Hopper1,
  27. Mark A. Jenkins1

Article first published online: 18 FEB 2013

DOI: 10.1002/humu.22262

Issue

Human Mutation

Human Mutation

Volume 34, Issue 3, pages 490–497, March 2013

Additional Information

How to Cite

Dowty, J. G., Win, A. K., Buchanan, D. D., Lindor, N. M., Macrae, F. A., Clendenning, M., Antill, Y. C., Thibodeau, S. N., Casey, G., Gallinger, S., Marchand, L. L., Newcomb, P. A., Haile, R. W., Young, G. P., James, P. A., Giles, G. G., Gunawardena, S. R., Leggett, B. A., Gattas, M., Boussioutas, A., Ahnen, D. J., Baron, J. A., Parry, S., Goldblatt, J., Young, J. P., Hopper, J. L. and Jenkins, M. A. (2013), Cancer Risks for MLH1 and MSH2 Mutation Carriers. Hum. Mutat., 34: 490–497. doi: 10.1002/humu.22262

Author Information

  1. 1

    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Parkville, Victoria, Australia

  2. 2

    Familial Cancer Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

  3. 3

    Department of Medical Genetics, Mayo Clinic, Rochester, Minnesota

  4. 4

    Department of Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Parkville, Victoria, Australia

  5. 5

    Familial Cancer Centres, Cabrini Health and Southern Health, Victoria, Australia

  6. 6

    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota

  7. 7

    Department of Preventive Medicine, University of Southern California, Los Angeles, California

  8. 8

    Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada

  9. 9

    University of Hawaii Cancer Research Center, Honolulu, Hawaii

  10. 10

    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington

  11. 11

    Flinders University Centre for Cancer Prevention and Control, Bedford Park, South Australia, Australia

  12. 12

    Familial Cancer Centre, Peter MacCallum Cancer Centre, Victoria, Australia

  13. 13

    Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia

  14. 14

    Conjoint Gastroenterology Laboratory, Royal Brisbane and Women's Hospital Research Foundation, Clinical Research Centre and Queensland Institute of Medical Research, Brisbane, Queensland, Australia

  15. 15

    Queensland Clinical Genetics Service, Royal Children's Hospital, Herston, Queensland, Australia

  16. 16

    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia

  17. 17

    Department of Medicine, University of Colorado School of Medicine and Denver VA Medical Center, Denver, Colorado

  18. 18

    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina

  19. 19

    New Zealand Familial Gastrointestinal Cancer Registry, Auckland City Hospital, Auckland, New Zealand

  20. 20

    Genetic Services and Familial Cancer Program of Western Australia, Perth, School of Paediatrics and Child Health, University of Western Australia, Australia

* Correspondence to: James G. Dowty, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Parkville, Victoria 3010, Australia; E-mail: jdowty@unimelb.edu.au

  1. Communicated by David E. Goldgar

  2. Contract grant sponsors: National Cancer Institute, National Institutes of Health (RFA # CA-95—011); Australasian Colorectal Cancer Family Registry (U01 CA097735); Familial Colorectal Neoplasia Collaborative Group (U01 CA074799) [USC]; Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01 CA074800); Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783); Seattle Colorectal Cancer Family Registry (U01 CA074794); University of Hawaii Colorectal Cancer Family Registry (U01 CA074806); National Health and Medical Research Council, Australia (1023434, 400160); The Cancer Council of Victoria, Australia (454695).

Publication History

  1. Issue published online: 18 FEB 2013
  2. Article first published online: 18 FEB 2013
  3. Accepted manuscript online: 15 DEC 2012 10:15PM EST
  4. Manuscript Accepted: 3 DEC 2012
  5. Manuscript Received: 7 AUG 2012

Funded by

  • National Cancer Institute, National Institutes of Health. Grant Number: RFA # CA-95—011
  • Australasian Colorectal Cancer Family Registry. Grant Number: U01 CA097735
  • Familial Colorectal Neoplasia Collaborative Group. Grant Number: U01 CA074799
  • Mayo Clinic Cooperative Family Registry for Colon Cancer Studies. Grant Number: U01 CA074800
  • Ontario Registry for Studies of Familial Colorectal Cancer. Grant Number: U01 CA074783
  • Seattle Colorectal Cancer Family Registry. Grant Number: U01 CA074794
  • University of Hawaii Colorectal Cancer Family Registry. Grant Number: U01 CA074806
  • National Health and Medical Research Council, Australia. Grant Numbers: 1023434, 400160
  • The Cancer Council of Victoria, Australia. Grant Number: 454695

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