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Figure S1. Multiple Sequence Alignment of TTI2/C8orf41 representative orthologs shows amino acid conservation of the mutated residue across species.

Figure S2. TTI2 silencing in HEK293 cells. HEK293 cells were co-transfected with RNAi oligonucleotides directed against TTI2 or an negative control RNAi oligonucleotides using Lipofectamine RNAi MAX (Invitrogen) according to the manufacturer's protocols.

Table S1. Summary of the clinical characteristics of children with TTI2 mutation

Table S2. IBD regions

Table S3. Number of variants identified by whole-exome sequencing

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