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A BRCA1 mutation in Native North American families †‡

  1. Alexander Liede1,*,
  2. Elaine Jack1,
  3. Robert A. Hegele2,
  4. Steven A. Narod1

Article first published online: 18 MAR 2002

DOI: 10.1002/humu.9027

Issue

Human Mutation

Human Mutation

Volume 19, Issue 4, page 460, April 2002

Additional Information

How to Cite

Liede, A., Jack, E., Hegele, R. A. and Narod, S. A. (2002), A BRCA1 mutation in Native North American families . Human Mutation, 19: 460. doi: 10.1002/humu.9027

Author Information

  1. 1

    University of Toronto and Sunnybrook & Women’s College Health Sciences Centre, Toronto, Canada

  2. 2

    University of Western Ontario, Robarts Research Institute, London, Ontario, Canada

*Centre for Research in Women’s Health, 790 Bay Street, Suite 750A Toronto, Ontario M5G 1N8, Canada

  1. †

    Communicated by Haig Kazazian, Jr.

  2. ‡

    Online Citation: Human Mutation, Mutation in Brief #498 (2001) Online http://www.interscience.wiley.com/humanmutation/pdf/mutation/498.pdf

Publication History

  1. Issue published online: 18 MAR 2002
  2. Article first published online: 18 MAR 2002
  3. Manuscript Accepted: 15 JAN 2002
  4. Manuscript Received: 26 OCT 2001

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Keywords:

  • Native North American;
  • breast cancer;
  • ovarian cancer;
  • BRCA1;
  • BRCA2;
  • BRCA;
  • ethnic;
  • aboriginal;
  • founder

Abstract

Germline mutations in the BRCA1 (MIM 113705) and BRCA2 (MIM 600185) genes have been identified for breast and ovarian cancer families of diverse ethnic backgrounds. To date, there have been no reports of Native North American families with mutations in BRCA1 or BRCA2. Here we report two families of aboriginal descent both with the same BRCA1 alterations (1510insG, 1506A>G). The families represent two aboriginal Canadian tribes (Cree and Ojibwe), although a common ancestral origin is likely. This is the first evidence of a BRCA1 mutation specific to aboriginal peoples of North America. © 2002 Wiley-Liss, Inc.

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