Verbal memory improved by D-amphetamine: influence of the testing effect
Article first published online: 29 JUN 2010
Copyright © 2010 John Wiley & Sons, Ltd.
Human Psychopharmacology: Clinical and Experimental
Volume 25, Issue 5, pages 377–387, July 2010
How to Cite
Zeeuws, I., Deroost, N. and Soetens, E. (2010), Verbal memory improved by D-amphetamine: influence of the testing effect. Hum. Psychopharmacol. Clin. Exp., 25: 377–387. doi: 10.1002/hup.1128
- Issue published online: 29 JUN 2010
- Article first published online: 29 JUN 2010
- Manuscript Accepted: 5 MAY 2010
- Manuscript Received: 12 NOV 2009
- testing effect;
- memory consolidation
The improvement of long-term retention of verbal memory after an acute administration of D-amphetamine in recall and recognition tasks has been ascribed to an influence of the drug on memory consolidation. Because recent research has demonstrated that intermediate testing is of overriding importance for retention, we investigated whether D-amphetamine modulates the repeated testing effect in verbal long-term recognition.
Forty men participated in two double blind placebo controlled studies. In Experiment 1, we manipulated the number of recognition tests and in Experiment 2, we compared repeated with nonrepeated testing of the same items.
Drug effects were observed on delayed tests only, leaving immediate recognition unaffected. Number of intermediate recognition tests and repeated testing of the same items were not affected by D-amphetamine.
We conclude that the D-amphetamine memory enhancement is not related to the testing effect. This result supports that D-amphetamine modulates other aspects of the consolidation process, probably related to context effects. Copyright © 2010 John Wiley & Sons, Ltd.