QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone
Version of Record online: 5 DEC 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Human Psychopharmacology: Clinical and Experimental
Volume 27, Issue 1, pages 39–42, January 2012
How to Cite
Suzuki, Y., Fukui, N., Watanabe, J., Ono, S., Sugai, T., Tsuneyama, N., Saito, M., Inoue, Y. and Someya, T. (2012), QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone. Hum. Psychopharmacol. Clin. Exp., 27: 39–42. doi: 10.1002/hup.1258
- Issue online: 25 JAN 2012
- Version of Record online: 5 DEC 2011
- Manuscript Accepted: 7 NOV 2011
- Manuscript Received: 3 AUG 2011
- Japan Society for the Promotion of Research. Grant Number: 20591362
- Mitsubishi Pharma Research Foundation and Health and Labour Sciences Research. Grant Number: H17-kokoro-002
- risperidone (RIS);
- QT interval;
A dose-dependent increase in risk of sudden cardiac death for the antipsychotic drug risperidone was reported. However, few reports have so far addressed QT prolongation associated with the use of risperidone or its major active metabolite, which is also used as a separate antipsychotic drug, paliperidone.
The present study evaluated associations between risperidone metabolism and QT interval in 61 psychiatric patients who had been receiving risperidone for ≥4 weeks at an average dosage of 4.7 mg/day. Plasma risperidone and paliperidone levels were measured and electrocardiographic measurements were also obtained.
There was no correlation between risperidone dosage and QTc or plasma risperidone levels and QTc. However, there was a significant positive correlation between plasma paliperidone levels and QTc (r = 0.361; p = 0.004). There was no correlation between age and dose-corrected plasma risperidone levels or between age and QTc. There was a significant positive correlation between age and dose-corrected plasma paliperidone levels (r = 0.290; p = 0.023).
Clinically, paliperidone is considered to play a more important role in QT prolongation than risperidone. Copyright © 2011 John Wiley & Sons, Ltd.