Effect of the cytochrome P450 2D6*10 allele on risperidone metabolism in Japanese psychiatric patients
Article first published online: 10 JAN 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Human Psychopharmacology: Clinical and Experimental
Volume 27, Issue 1, pages 43–46, January 2012
How to Cite
Suzuki, Y., Fukui, N., Tsuneyama, N., Watanabe, J., Ono, S., Sugai, T., Saito, M., Inoue, Y. and Someya, T. (2012), Effect of the cytochrome P450 2D6*10 allele on risperidone metabolism in Japanese psychiatric patients. Hum. Psychopharmacol. Clin. Exp., 27: 43–46. doi: 10.1002/hup.1260
- Issue published online: 25 JAN 2012
- Article first published online: 10 JAN 2012
- Manuscript Accepted: 19 NOV 2011
- Manuscript Revised: 11 NOV 2011
- Manuscript Received: 13 SEP 2011
- Grant-in-Aid for Scientific Research (KAKENHI). Grant Number: 20591362
- Mitsubishi Pharma Research Foundation and Health and Labour Sciences Research Grants. Grant Number: H17-kokoro-002
- active moiety;
The sum of the serum levels of risperidone (RIS) and 9-hydroxyrisperidone (9-OH-RIS), which is the active moiety serum level, could be important for estimating the clinical effects of RIS. However, there have been no consistent results reported about the relationship between cytochrome P450 (CYP) 2D6*10 allele and plasma 9-OH-RIS or active moiety levels. We investigated the effect of the number of CYP2D6*10 alleles on steady-state plasma RIS, 9-OH-RIS, and active moiety levels in Japanese patients.
Steady-state plasma RIS, 9-OH-RIS, and active moiety levels were measured in 64 patients treated with an average dosage of 4.6 mg/day.
The number of CYP2D6*10 alleles significantly affected dose-corrected plasma RIS levels (p = 0.001), and the median concentrations in ng/ml/mg were 0.94 (0 allele) vs. 1.73 (1 allele) vs. 3.05 (2 alleles). The number of CYP2D6*10 alleles did not affect plasma 9-OH-RIS or active moiety levels.
The present study shows that the number of CYP2D6*10 alleles affected plasma RIS levels but not plasma 9-OH-RIS and plasma active moiety levels. Because the plasma active moiety levels can influence antipsychotic effects or side effects, the genetic screening of the CYP2D6*10 allele for RIS in Asian populations may not be clinically important. Copyright © 2012 John Wiley & Sons, Ltd.