Serotonin 6 receptor gene and schizophrenia: case-control study and meta-analysis
Article first published online: 10 JAN 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Human Psychopharmacology: Clinical and Experimental
Volume 27, Issue 1, pages 63–69, January 2012
How to Cite
Kishi, T., Fukuo, Y., Okochi, T., Kawashima, K., Kitajima, T., Inada, T., Ozaki, N., Musso, G. M., Kane, J. M., Correll, C. U. and Iwata, N. (2012), Serotonin 6 receptor gene and schizophrenia: case-control study and meta-analysis. Hum. Psychopharmacol. Clin. Exp., 27: 63–69. doi: 10.1002/hup.1266
- Issue published online: 25 JAN 2012
- Article first published online: 10 JAN 2012
- Manuscript Accepted: 22 NOV 2011
- Manuscript Received: 26 SEP 2011
- Japan Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labor and Welfare
- Japan Health Sciences Foundation
- Japan Research Foundation for Clinical Pharmacology
- Ministry of Education
- serotonin 6 receptor gene (HTR6);
Several lines of evidence suggest that genetic alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of schizophrenia. We sought to assess the relationship between genotype alterations in 5-HT6 receptors and schizophrenia both in a case-control study and a meta-analysis.
We conducted an association study of the 5-HT6 receptor gene (HTR6) in Japanese patients with schizophrenia (n = 836) and controls (n = 857). Five tagging single-nucleotide polymorphisms (SNPs), including rs1805054 (C267T) in HTR6, were selected. In addition, we carried out a meta-analysis between rs1805054, which has been examined in other studies, and schizophrenia, searching PubMed through August 2011.
There were no significant associations between the tagging SNPs in HTR6 and schizophrenia in any of the genotype models in both the simple and the multiple logistic regression analyses correcting for potential confounds. Similarly, no significant association was found in the all-marker haplotype multiple logistic regression analysis (p = 0.491).
Moreover, in the meta-analysis of rs1805054, drawing data from five studies, including our own (schizophrenia patients = 1366, controls = 1376), rs1805054 was also not associated with schizophrenia.
Our results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia. Copyright © 2012 John Wiley & Sons, Ltd.