Prescription profiles for pharmacological treatment of Japanese inpatients with schizophrenia: comparison between 2007 and 2009
Article first published online: 16 JAN 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Human Psychopharmacology: Clinical and Experimental
Volume 27, Issue 1, pages 70–75, January 2012
How to Cite
Yoshio, T., Inada, T., Uno, J., Miwa, T., Kitagawa, K., Miyahara, Y., Umeda, K., Kato, T., Inagaki, A. and Nabeshima, T. (2012), Prescription profiles for pharmacological treatment of Japanese inpatients with schizophrenia: comparison between 2007 and 2009. Hum. Psychopharmacol. Clin. Exp., 27: 70–75. doi: 10.1002/hup.1272
- Issue published online: 25 JAN 2012
- Article first published online: 16 JAN 2012
- Manuscript Accepted: 12 DEC 2011
- Manuscript Revised: 4 DEC 2011
- Manuscript Received: 23 JUN 2011
- prescription survey;
- second-generation antipsychotics
Background and Objective
Pharmacological treatment of schizophrenic patients in Japan is characterized by polypharmacy with high doses of antipsychotics. In this study, we examined the profiles of antipsychotic drug therapy in 2007 and 2009 to determine if there have been any recent shifts in treatment strategy.
The subjects were schizophrenic inpatients (ICD-10-F20) admitted to 100 hospitals in 2007 and 152 hospitals in 2009. Information on the psychotropic agents prescribed on specified days in November 2007 and 2009 was acquired for each patient.
Although no changes were observed in the rate of antipsychotic medications being prescribed, the rate of antipsychotic monotherapy in 2009 increased significantly. In 2007, among 15,761 patients, 4977 (31.6%) received antipsychotic monotherapy (i.e., administration of a single antipsychotic medication). In 2009, among 22,911 patients, 7741 (33.8%) received antipsychotic monotherapy.
The rate of use of antipsychotic monotherapy has gradually increased, although the total dose has not changed significantly. The increase in the concomitant use of two or more second-generation antipsychotics is a recent trend in Japan, despite the lack of information on the efficacy and safety of this treatment strategy. Copyright © 2012 John Wiley & Sons, Ltd.