These authors contributed equally to this work.
A meta-analysis of inositol for depression and anxiety disorders
Article first published online: 3 DEC 2013
Copyright © 2013 John Wiley & Sons, Ltd.
Human Psychopharmacology: Clinical and Experimental
Volume 29, Issue 1, pages 55–63, January 2014
How to Cite
Mukai, T., Kishi, T., Matsuda, Y. and Iwata, N. (2014), A meta-analysis of inositol for depression and anxiety disorders. Hum. Psychopharmacol. Clin. Exp., 29: 55–63. doi: 10.1002/hup.2369
- Issue published online: 14 JAN 2014
- Article first published online: 3 DEC 2013
- Manuscript Accepted: 16 OCT 2013
- Manuscript Revised: 13 SEP 2013
- Manuscript Received: 1 JUN 2013
- Daiichi Sankyo
- Dainippon Sumitomo
- Eli Lilly
- major depressive disorder;
- bipolar depression;
- premenstrual dysphoric disorder;
- anxiety disorder;
This study is a meta-analysis of inositol as a treatment for depression and anxiety disorders.
PubMed, Cochrane Library database, and PsycINFO were searched up to 14 August 2013. A systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials (RCTs) were conducted comparing inositol for depressed or anxiety disorder patients.
Seven RCTs in depression (two bipolar depression studies, one bipolar depression and major depressive disorder (MDD) study, two MDD studies, and two premenstrual dysphoric disorder (PMDD) studies) (n = 242) were identified. Four RCTs in anxiety disorders (two obsessive–compulsive disorder studies, one panic disorder study, and one posttraumatic stress disorder study) (n = 70) were also identified. There were no statistically significant effects of inositol on depressive, anxiety, and obsessive–compulsive symptoms and discontinuation (all-cause, side effects, and worsening psychiatric symptoms). However, inositol had marginally more responders in depression than placebo (p = 0.06), and inositol showed a trend towards superior efficacy for depressive symptoms in patients with PMDD (p = 0.07). Inositol marginally caused gastrointestinal upset compared with placebo (p = 0.06).
Our results suggest that inositol may be beneficial for depressed patients, especially those with PMDD. The main limitation of this report is that a small number of studies were included in this meta-analysis. Copyright © 2013 John Wiley & Sons, Ltd.