Study supported by the ‘Institut de Recherches Internationales Servier’, 6 place des Pléiades, 92415 Courbevoie Cedex, France.
Tianeptine and paroxetine in major depressive disorder, with a special focus on the anxious component in depression: an international, 6-week double-blind study†
Article first published online: 25 APR 2001
Copyright © 2001 John Wiley & Sons, Ltd.
Human Psychopharmacology: Clinical and Experimental
Volume 16, Issue 3, pages 219–227, April 2001
How to Cite
Lepine, J. P., Altamura, C., Ansseau, M., Gutierrez, J. L. A., Bitter, I., Lader, M. and Waintraub, L. (2001), Tianeptine and paroxetine in major depressive disorder, with a special focus on the anxious component in depression: an international, 6-week double-blind study. Hum. Psychopharmacol. Clin. Exp., 16: 219–227. doi: 10.1002/hup.289
- Issue published online: 25 APR 2001
- Article first published online: 25 APR 2001
- Manuscript Accepted: 25 JAN 2001
- anxious symptoms;
- major depressive disorder;
Tianeptine (37.5 mg/day) and paroxetine (20 mg/day) were compared in a population of depressive patients without past or current history of co-morbid anxiety and/or important anxiolytic treatment. In a 6-week, double blind trial, the special focus was on anxious symptoms.
Both drugs showed good efficacy on depressive symptomatology, assessed with MADRS and HDRS, but no difference was detected between tianeptine and paroxetine, for any assessment criterion. Despite the choice of selected depressive patients, without any co-morbid anxious disorder, anxiety scale scores at inclusion (HAMA and BAS) were appreciable but correlated poorly with depressive scores. Both tianeptine and paroxetine improved the apparent anxious component in depression. Tolerability of both drugs was good, although significantly better with tianeptine.
Thus tianeptine and paroxetine are effective and safe treatments for major depression and may also act directly on the anxious component of the psychopathology. Copyright © 2001 John Wiley & Sons, Ltd.