A critical review of akathisia, and its possible association with suicidal behaviour
Article first published online: 12 SEP 2001
Copyright © 2001 John Wiley & Sons, Ltd.
Human Psychopharmacology: Clinical and Experimental
Volume 16, Issue 7, pages 495–505, October 2001
How to Cite
Hansen, L. (2001), A critical review of akathisia, and its possible association with suicidal behaviour. Hum. Psychopharmacol. Clin. Exp., 16: 495–505. doi: 10.1002/hup.325
- Issue published online: 25 OCT 2001
- Article first published online: 12 SEP 2001
- Manuscript Accepted: 16 JUL 2001
The purpose of this paper was to make a critical review of akathisia, based on the principles of evidence-based medicine, and to explore a possible link between akathisia and suicidal behaviour (suicidal thinking, parasuicide and completed suicide). An extensive systematic search was carried out on three major databases, Embase, ClinPsych and Medline. Fifty-seven relevant references were found, and a further 26 references were reviewed after careful selection from the references of the original references. The Cochrane Library did not contain any systematic reviews on the subject. Akathisia can be caused by several different groups of drugs, but most frequently by antipsychotics and to a lesser extent antidepressants. Research into akathisia is made considerably more difficult by the lack of a universally agreed definition of the condition. The underlying pathophysiology is still far from clear, but the literature offers guidelines on less hazardous management regimes for patients. On the basis of the existing literature, akathisia cannot at this stage unequivocally be linked to suicidal behaviour. It is certain, however, that the condition of akathisia does cause considerable distress in an already vulnerable group of patients. Because it is largely avoidable, new, more rigorous strategies must be put in place to prevent it. Copyright © 2001 John Wiley & Sons, Ltd.