Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative–antioxidative systems
Article first published online: 14 FEB 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Human Psychopharmacology: Clinical and Experimental
Volume 22, Issue 2, pages 67–73, March 2007
How to Cite
Sarandol, A., Sarandol, E., Eker, S. S., Erdinc, S., Vatansever, E. and Kirli, S. (2007), Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative–antioxidative systems. Hum. Psychopharmacol. Clin. Exp., 22: 67–73. doi: 10.1002/hup.829
- Issue published online: 5 MAR 2007
- Article first published online: 14 FEB 2007
- Manuscript Accepted: 28 DEC 2006
- Manuscript Received: 1 JUN 2006
- major depressive disorder;
- oxidative stress;
- antidepressant treatment;
The aim of the present study was to investigate the oxidative–antioxidative systems and effects of different antidepressants on these systems in patients with major depressive disorder (MDD).
Ninety-six patients with a Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) diagnosis of MDD and 54 healthy controls were included in the study. Plasma malondialdehyde (MDA) levels and susceptibility of red blood cells (RBCs) to oxidation were determined to investigate the oxidative status, plasma vitamin E, vitamin C, serum total carotenoid levels, total antioxidant capacity (TAOC), RBC superoxide dismutase (SOD) and whole blood glutathione peroxidase (GPx) activities were measured to investigate the antioxidative defence before and after 6 weeks of antidepressant treatment.
Plasma MDA levels and susceptibility of RBCs to oxidation were significantly higher in the MDD group compared with the control group. RBC SOD activity was significantly increased in patients with MDD, and furthermore there was a significant positive correlation between the severity of the disease and SOD activity.
MDD is accompanied with oxidative stress; however, oxidative–antioxidative systems do not seem to be affected by 6 weeks of antidepressant treatment. Copyright © 2007 John Wiley & Sons, Ltd.