Research Article

Ultrasound bone mass in schizophrenic patients on antipsychotic therapy

  1. Purificación Rey-Sánchez1,
  2. Jesús M Lavado-García2,
  3. María L Canal-Macías1,
  4. María A Gómez-Zubeldia1,
  5. Raúl Roncero-Martín1,
  6. Juan D Pedrera-Zamorano1,*

Article first published online: 17 NOV 2008

DOI: 10.1002/hup.984

Issue

Human Psychopharmacology: Clinical and Experimental

Human Psychopharmacology: Clinical and Experimental

Volume 24, Issue 1, pages 49–54, January 2009

Additional Information

How to Cite

Rey-Sánchez, P., Lavado-García, J. M., Canal-Macías, M. L., Gómez-Zubeldia, M. A., Roncero-Martín, R. and Pedrera-Zamorano, J. D. (2009), Ultrasound bone mass in schizophrenic patients on antipsychotic therapy. Human Psychopharmacology: Clinical and Experimental, 24: 49–54. doi: 10.1002/hup.984

Author Information

  1. 1

    Department of Nursing, University of Extremadura, Spain

  2. 2

    Department of Medicine I, University of Extremadura, Spain

*Departamento de Enfermería, Universidad de Extremadura, 10071 Cáceres, Spain.

Publication History

  1. Issue published online: 22 DEC 2008
  2. Article first published online: 17 NOV 2008
  3. Manuscript Accepted: 17 SEP 2008
  4. Manuscript Received: 21 APR 2008

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Keywords:

  • antipsychotic drugs;
  • bone mass;
  • parathyroid hormone;
  • phalangeal bone ultrasound;
  • prolactin;
  • vitamin D

Abstract

Objective

To determine bone mass using quantitative phalangeal bone ultrasound in institutionalized schizophrenic patients under chronic treatment with antipsychotic drugs.

Methods

A total of 73 patients with schizophrenia (25 women, mean age 59.84 ± 17.01 years; 48 men, mean age 61.89 ± 12.95 years) and 73 healthy subjects (25 women, mean age 60.37 ± 17.16 years; 48 men, mean age 61.24 ± 13.09 years) participated in the study. Bone status was assessed using an ultrasound device that measures the amplitude-dependent speed of sound (Ad-SoS) in metres per second. Measurements were made on the phalanges (II–V) of the non-dominant hand, and the mean value was computed.

Results

The schizophrenic women had higher levels of prolactin (PRL), parathyroid hormone (PTH), alkaline phosphatase (AlPh), and tartrate-resistant acid phosphatase (TRAP) (all p < 0.0001), and lower 25-hydroxyvitamin D(25(OH)D3) levels (p < 0.0001) and Ad-SoS values (p < 0.05) than controls. Ad-SoS was higher in schizophrenic men (p < 0.05).

Conclusions

Schizophrenic women in treatment with antipsychotic drugs had a loss of phalangeal bone mass that was associated with the levels of vitamin D or PTH, and increased bone turnover. Copyright © 2008 John Wiley & Sons, Ltd.

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