A modelling framework for the quick estimate of flood inundation and the resultant damages is developed in this paper. The model, called the flood economic impact analysis system (FEIAS), can be applied to a river reach of any hydrogeological river basin. For the development of the integrated modelling framework, three models were employed: (1) a modelling scheme based on the Hydrological Simulation Program FORTRAN model that was developed for any geomorphological river basin, (2) a river flow/floodplain model, and (3) a flood loss estimation model. The first sub-model of the flood economic impact analysis system simulates the hydrological processes for extended periods of time, and its output is used as input to a second component, the river/floodplain model. The hydraulic model MIKE 11 (quasi-2D) is the river/floodplain model employed in this study. The simulated flood parameters from the hydraulic model MIKE 11 (quasi-2D) are passed, at the end of each time step, to a third component, the flood loss model for the estimation of flood damage. In the present work, emphasis was given to the seasonal variation of Manning's coefficient (n), which is an important parameter for the determination of the flood inundation in hydraulic modelling. High values of Manning's coefficient for a channel indicate high flow resistance. The riparian vegetation can have a large impact on channel resistance. The modelling framework developed in this paper was used to investigate the role of riparian vegetation in reducing flood damage. Moreover, it was used to investigate the influence of cutting riparian vegetation scenarios on the flow characteristics. The proposed framework was applied to the downstream part of the Koiliaris River basin in Crete, Greece, and was tested and validated with historical data. Copyright © 2012 John Wiley & Sons, Ltd.