The authors declare they have no competing interests.
Basic Science Review
Genetics of the innate immune response in inflammatory bowel disease†
Article first published online: 19 DEC 2006
Copyright © 2006 Crohn's & Colitis Foundation of America, Inc.
Inflammatory Bowel Diseases
Volume 13, Issue 3, pages 338–355, March 2007
How to Cite
Van Limbergen, J., Russell, R. K., Nimmo, E. R., Ho, G.-T., Arnott, I. D., Wilson, D. C. and Satsangi, J. (2007), Genetics of the innate immune response in inflammatory bowel disease. Inflamm Bowel Dis, 13: 338–355. doi: 10.1002/ibd.20096
- Issue published online: 16 FEB 2007
- Article first published online: 19 DEC 2006
- Manuscript Accepted: 28 NOV 2006
- Manuscript Received: 26 NOV 2006
- Action Medical Research
- University of Edinburgh. Medical Faculty Fellowship
- Wellcome Trust Programme. Grant Number: 072789/Z/03/Z
- GI/Nutrition Research Fund
- Department of Child Life and Health, University of Edinburgh
- inflammatory bowel disease;
- innate immunity;
The discovery of nucleotide-binding oligomerization domain 2/caspase recruitment domain-containing protein 15 (NOD2/CARD15) as the first susceptibility gene in Crohn's disease (CD) has shifted the focus of research into the pathogenesis of inflammatory bowel disease (IBD) firmly to the innate immune response and the integrity of the epithelial barrier. The subsequent implication in IBD of variant alleles of OCTN, DLG5, MDR1, and TLRs has provided further support for a new, more complex model of innate immunity function in the gastrointestinal tract. In this review, we examine the recent advances in our understanding of the influence of genetics of the innate immune response on IBD. We will focus on germline variation of genes encoding pathogen-recognition receptors, proteins involved in epithelial homeostasis and secreted antimicrobial proteins.
(Inflamm Bowel Dis 2007)