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CCFA Microbial–Host Interactions Workshop: Highlights and key observations

  1. R. Balfour Sartor MD1,†,*,
  2. Richard S. Blumberg MD2,
  3. Jonathan Braun MD, PhD3,
  4. Charles O. Elson MD4,
  5. Lloyd F. Mayer MD5

Article first published online: 9 FEB 2007

DOI: 10.1002/ibd.20114

Issue

Inflammatory Bowel Diseases

Inflammatory Bowel Diseases

Volume 13, Issue 5, pages 600–619, May 2007

Additional Information

How to Cite

Sartor, R. B., Blumberg, R. S., Braun, J., Elson, C. O. and Mayer, L. F. (2007), CCFA Microbial–Host Interactions Workshop: Highlights and key observations. Inflammatory Bowel Diseases, 13: 600–619. doi: 10.1002/ibd.20114

Author Information

  1. 1

    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

  2. 2

    Brigham & Women's, Hospital, Boston, Massachusetts

  3. 3

    University of California at Los Angeles, Los Angeles, California

  4. 4

    University of Alabama at Birmingham, Birmingham, Alabama

  5. 5

    Mount Sinai School of Medicine, New York, New York

  1. †

    R. Balfour Sartor, MD, is the Chairperson of the Workshop Organizing Committee. Workshop sponsored by the Crohn's & Colitis Foundation of America, and supported in part by an unrestricted educational grant from UCB Pharma.

*c/o Marjorie Merrick, Vice President of Research and Scientific Programs, Crohn's & Colitis Foundation of America, 386 Park Avenue South, 17th Floor, New York, New York 10016. E-mail: mmerrick@ccfa.org

Publication History

  1. Issue published online: 6 APR 2007
  2. Article first published online: 9 FEB 2007
  3. Manuscript Accepted: 21 DEC 2006
  4. Manuscript Received: 13 DEC 2006

Funded by

  • Crohn's & Colitis Foundation of America
  • UCB Pharma

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Keywords:

  • inflammatory bowel diseases;
  • IBD;
  • microbial-host interactions;
  • bacteria;
  • colitis

Abstract

This article provides a summary of the proceedings of the CCFA Microbial–Host Interactions Workshop that was held in St. Petersburg, Florida, on March 16–19, 2006. Approximately 75 senior and junior investigators from around the world shared their most current research findings through oral presentations, poster sessions, and active discussion. Because intestinal microbiota are significant contributors in the development of inflammatory bowel diseases (IBD), understanding the body's responses to and interactions with microbes, especially in the colon and distal small intestine, is critical to elucidating the etiology and pathogenesis of IBD and developing effective therapeutic interventions. Major advances have occurred recently in molecular detection of luminal bacterial species, identifying dominant microbial antigens that drive intestinal inflammation, the mechanisms of innate immune and epithelial responses to bacteria, and regulation of inflammation by innate and acquired immune cells.

(Inflamm Bowel Dis 2007)

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