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CCFA Microbial–Host Interactions Workshop: Highlights and key observations

Authors

  • R. Balfour Sartor MD,

    Corresponding author
    1. University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    • c/o Marjorie Merrick, Vice President of Research and Scientific Programs, Crohn's & Colitis Foundation of America, 386 Park Avenue South, 17th Floor, New York, New York 10016. E-mail: mmerrick@ccfa.org
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    • R. Balfour Sartor, MD, is the Chairperson of the Workshop Organizing Committee. Workshop sponsored by the Crohn's & Colitis Foundation of America, and supported in part by an unrestricted educational grant from UCB Pharma.

  • Richard S. Blumberg MD,

    1. Brigham & Women's, Hospital, Boston, Massachusetts
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  • Jonathan Braun MD, PhD,

    1. University of California at Los Angeles, Los Angeles, California
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  • Charles O. Elson MD,

    1. University of Alabama at Birmingham, Birmingham, Alabama
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  • Lloyd F. Mayer MD

    1. Mount Sinai School of Medicine, New York, New York
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Abstract

This article provides a summary of the proceedings of the CCFA Microbial–Host Interactions Workshop that was held in St. Petersburg, Florida, on March 16–19, 2006. Approximately 75 senior and junior investigators from around the world shared their most current research findings through oral presentations, poster sessions, and active discussion. Because intestinal microbiota are significant contributors in the development of inflammatory bowel diseases (IBD), understanding the body's responses to and interactions with microbes, especially in the colon and distal small intestine, is critical to elucidating the etiology and pathogenesis of IBD and developing effective therapeutic interventions. Major advances have occurred recently in molecular detection of luminal bacterial species, identifying dominant microbial antigens that drive intestinal inflammation, the mechanisms of innate immune and epithelial responses to bacteria, and regulation of inflammation by innate and acquired immune cells.

(Inflamm Bowel Dis 2007)

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