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Spectrum and frequency of ophthalmologic manifestations in patients with inflammatory bowel disease: A prospective single-center study

Authors

  • Taxiarchis Felekis MD,

    1. Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece
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    • The first 2 authors contributed equally.

  • Konstantinos Katsanos MD,

    1. 1st Department of Internal Medicine, & Hepato-Gastroenterology Unit, University Hospital of Ioannina, Ioannina, Greece
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    • The first 2 authors contributed equally.

  • Margarita Kitsanou MD,

    1. 1st Department of Internal Medicine, & Hepato-Gastroenterology Unit, University Hospital of Ioannina, Ioannina, Greece
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  • Nikolaos Trakos MD,

    1. Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece
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  • Vasileios Theopistos MD,

    1. 1st Department of Internal Medicine, & Hepato-Gastroenterology Unit, University Hospital of Ioannina, Ioannina, Greece
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  • Dimitrios Christodoulou MD,

    1. 1st Department of Internal Medicine, & Hepato-Gastroenterology Unit, University Hospital of Ioannina, Ioannina, Greece
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  • Ioannis Asproudis MD, PhD,

    1. Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece
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  • Epameinondas V. Tsianos MD, PhD

    Corresponding author
    1. 1st Department of Internal Medicine, & Hepato-Gastroenterology Unit, University Hospital of Ioannina, Ioannina, Greece
    • 1st Department of Internal Medicine & Hepato-Gastroenterology Unit, Medical School, University of Ioannina, 451 10 Ioannina, Greece
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Abstract

Background: The frequency and spectrum of ophthalmologic manifestations in patients with inflammatory bowel disease (IBD) has been reported to vary among studies; however, rare and silent manifestations have not been extensively studied.

Methods: This was a prospective study of 60 patients diagnosed with IBD who underwent full ophthalmologic examination, including visual acuity, slit lamp examination of the anterior segments, intraocular pressure, and fundus examination accompanied by color photography. Thirty-seven (61,7%) patients were diagnosed with ulcerative colitis (UC) and 23 (38,3%) with Crohn's disease (CD). Data from 276 control individuals were used for the determination of the prevalence of dry eye in our area.

Results: Ophthalmologic manifestations were diagnosed in 26 (43%) patients (14 UC, 12 CD; 12 males and 14 females). Conjunctivitis was diagnosed in 1 patient (CD), episcleritis in 2 patients (UC), and iridocyclitis in 3 (CD). Fundus examination showed 1 patient (CD) with unilateral choroiditis, 1 (UC) with retinal vasculitis, and 1 (CD) with optic neuritis. Retinal pigment epithelium disturbances (RPED) were present in 3 patients (1 CD, 2 UC) and 2 had serous retinal detachment. In total, 13/60 patients (22%) had dry eye compared with the 11% prevalence in controls. Eight patients developed glucocorticosteroid-induced cataracts, 2 of them treated surgically.

Conclusions: This study demonstrated the prevalence of the spectrum of ophthalmologic manifestations in the IBD population, including some rare and silent findings that may merit consideration and early intervention.

(Inflamm Bowel Dis 2008)

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