1536-4844/asset/IBD_left.gif?v=1&s=9aca2b5041534c51cac4bb66560294c77a457a07)
1536-4844/asset/IBD_right.gif?v=1&s=402e3e241083497ae622916e85e47f64138255a4)
Original Article
You have full text access to this OnlineOpen article
Bacteria-free solution derived from lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function
Article first published online: 16 APR 2009
DOI: 10.1002/ibd.20930
Copyright © 2009 Crohn's & Colitis Foundation of America, Inc.
Additional Information
How to Cite
Petrof, E. O., Claud, E. C., Sun, J., Abramova, T., Guo, Y., Waypa, T. S., He, S.-M., Nakagawa, Y. and Chang, E. B. (2009), Bacteria-free solution derived from lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function. Inflamm Bowel Dis, 15: 1537–1547. doi: 10.1002/ibd.20930
Publication History
- Issue published online: 11 SEP 2009
- Article first published online: 16 APR 2009
- Manuscript Accepted: 11 FEB 2009
- Manuscript Received: 10 FEB 2009
Funded by
- Crohn's and Colitis Foundation of Canada
- National Institutes of Health. Grant Numbers: DK064840, HD043839, AT004044, DK47722
- Digestive Disease Research Core Center. Grant Number: DK42086
REFERENCES
- 1, . Bacteria in the intestine, helpful residents or enemies from within? Infect Immun. 2008; 76: 3360–3373.
- 2, , , et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006; 444: 1027–1031.
- 3, , , et al. Microbial ecology: human gut microbes associated with obesity. Nature. 2006; 444: 1022– 1023.
- 4, . Probiotics as functional food in the treatment of diarrhea. Curr Opin Clin Nutr Metab Care. 2006; 9: 717–721.
- 5, , , et al. The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology. 2007; 133: 24–33.
- 6, , , et al. Molecular characterization of rectal mucosa-associated bacterial flora in inflammatory bowel disease. Inflamm Bowel Dis. 2005; 11: 481–487.
- 7, . Irritable bowel syndrome and probiotics: from rationale to clinical use. Curr Opin Gastroenterol. 2005; 21: 697–701.
- 8, , , et al. Isolation and characterisation of new putative probiotic bacteria from human colonic flora. Br J Nutr. 2007; 97: 725–734.
- 9, , , et al. Probiotic Lactobacillus reuteri suppress proinflammatory cytokines via c-Jun. Inflamm Bowel Dis. 2008; 14: 1068–1083.
- 10. Lactobacillemia: an emerging cause of infection in both the immunocompromised and the immunocompetent host. J Natl Med Assoc. 2000; 92: 83–86.
- 11, , , et al. Lactobacillemia in three patients with AIDS. Clin Infect Dis. 1995; 21: 1460–1462.
- 12, , . Lactobacillus species as opportunistic pathogens in immunocompromised patients. Eur J Clin Microbiol Infect Dis. 1998; 17: 887–888.
- 13, , , et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect. 1996; 32: 165–167.
- 14, , , et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J. 2005; 24: 278–280.
- 15, , , et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet. 2008; 371: 651–659.
- 16, , , et al. Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology. 2003; 124: 1202–1209.
- 17, , , et al. Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition. Gastroenterology. 2004; 127: 1474–1487.
- 18, , , et al. Liver abscess due to a Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis. 1999; 28: 1159–1160.
- 19, , . Safety of Lactobacillus strains used as probiotic agents. Clin Infect Dis. 2002; 34: 1283–1284; author reply 1284–1285.
- 20, , , et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis. 2005; 40: 1625–1634.
- 21, , , et al. Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils. J Cell Biol. 1993; 123: 895–907.
- 22, , , et al. Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice. Proc Natl Acad Sci U S A. 1993; 90: 587–591.
- 23, , , et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med. 1992; 176: 1693–1702.
- 24, , , et al. The luminal short-chain fatty acid butyrate modulates NF-kappaB activity in a human colonic epithelial cell line. Gastroenterology. 2000; 118: 724–734.
- 25, , , et al. Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cells. Gastroenterology. 2003; 124: 1395–1407.
- 26, , , et al. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci U S A. 1999; 96: 10403–10408.
- 27, , . Large- and small-scale purification of mammalian 26S proteasomes. Methods Enzymol. 2005; 399: 227– 240.
- 28, , , et al. Soluble factors from the probiotic Lactobacillus GG activate MAP kinases and induce cytoprotective heat shock proteins in intestinal epithelial cells. Am J Physiol Cell Physiol. 2006; 290: C1018–1030.
- 29, , , et al. Monocyte-chemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa. Gastroenterology. 1995; 108: 40–50.
- 30. Chemokines in the inflammatory bowel diseases. J Clin Immunol. 1999; 19: 266–272.
- 31, , , et al. Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis. J Clin Invest. 2006; 116: 3195–3203.
- 32, , , et al. DNA from probiotic bacteria modulates murine and human epithelial and immune function. Gastroenterology. 2004; 126: 1358–1373.
- 33, , , et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature. 2007; 446: 557–561.
- 34, , , et al. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med. 2003; 9: 575–581.
- 35, , , et al. The therapeutic potential of the proteasome in leukaemia. Hematol Oncol. 2008; 26: 73–81.
- 36, , , et al. Molecular analysis of commensal host-microbial relationships in the intestine. Science. 2001; 291: 881–884.
- 37, , , et al. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 2004; 118: 229–241.
- 38, , , et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004; 101: 15718–15723.
- 39, , , et al. Host-bacterial mutualism in the human intestine. Science. 2005; 307: 1915–1920.
- 40, , , et al. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol. 2006; 8: 1327–1336.
- 41, , . TLR signaling in the gut in health and disease. J Immunol. 2005; 174: 4453–4460.
- 42, , , et al. Experimental models of inflammatory bowel disease. Gastroenterology. 1995; 109: 1344–1367.
- 43, . Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases. J Intern Med. 2008; 263: 597–606.
- 44, , , et al. The normal Lactobacillus flora of healthy human rectal and oral mucosa. J Appl Microbiol. 1998; 85: 88–94.
- 45, , , et al. Diversity of the human intestinal microbial flora. Science. 2005; 308: 1635–1638.
- 46, , , et al. Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice. Inflamm Bowel Dis. 2002; 8: 71–80.
- 47, , , et al. Modulation of the effect of dextran sulfate sodium-induced acute colitis by the administration of different probiotic strains of Lactobacillus and Bifidobacterium. Dig Dis Sci. 2004; 49: 320–327.
- 48, , , et al. Proteasome inhibition attenuates nitric oxide synthase expression, VCAM-1 transcription and the development of chronic colitis. J Pharmacol Exp Ther. 1997; 282: 1615–1622.
- 49, , , et al. Enhanced intestinal expression of the proteasome subunit low molecular mass polypeptide 2 in patients with inflammatory bowel disease. Dis Colon Rectum. 2007; 50: 337–348; discussion 348–350.
- 50, , , et al. Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells. J Immunol. 2006; 176: 1228–1237.
- 51, , , et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A. 2008; 105: 16731–16736.
- 52, , , et al. Inhibitory effects of Lactobacillus plantarum lipoteichoic acid (LTA) on Staphylococcus aureus LTA-induced tumor necrosis factor-alpha production. J Microbiol Biotechnol. 2008; 18: 1191–1196.
- 53, , , et al. Lipoteichoic acid isolated from Lactobacillus plantarum inhibits lipopolysaccharide-induced TNF-alpha production in THP-1 cells and endotoxin shock in mice. J Immunol. 2008; 180: 2553–2561.