Role of transforming growth factor-β in inflammatory bowel disease and colitis-associated colon cancer


  • Linda A. Feagins MD

    Corresponding author
    1. Divisions of Gastroenterology and Hepatology, VA North Texas Health Care System, and the University of Texas Southwestern Medical Center at Dallas, Dallas, Texas
    • Division of Gastroenterology (111B1), Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216
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Transforming growth factor-β (TGF-β) plays a central role in a wide array of cellular functions including control of cell growth and differentiation, embryonic development, wound healing, angiogenesis, and immune regulation. In the gastrointestinal tract, TGF-β can either promote or suppress inflammation and cancer formation. This report reviews recent data on the role of TGF-β in the pathogenesis of inflammatory bowel disease and how TGF-β might contribute to the cancer risk associated with chronic inflammation of the gut. (Inflamm Bowel Dis 2010)