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Basic Science Review
Toll-like receptors in inflammatory bowel diseases: A decade later
Article first published online: 9 APR 2010
DOI: 10.1002/ibd.21282
Copyright © 2010 Crohn's & Colitis Foundation of America, Inc.
Additional Information
How to Cite
Cario, E. (2010), Toll-like receptors in inflammatory bowel diseases: A decade later. Inflamm Bowel Dis, 16: 1583–1597. doi: 10.1002/ibd.21282
Publication History
- Issue published online: 20 AUG 2010
- Article first published online: 9 APR 2010
- Manuscript Accepted: 15 FEB 2010
- Manuscript Received: 4 FEB 2010
Funded by
- Crohn's and Colitis Foundation of America. Grant Number: 1790
- Deutsche Forschungsgemeinschaft. Grant Number: CA226/4-2
- Abstract
- Article
- References
- Cited By
Keywords:
- Toll-like receptor;
- inflammatory bowel disease;
- review;
- innate immunity;
- host defense;
- intestinal mucosa;
- Crohn's disease;
- ulcerative colitis
Abstract
Differential alteration of Toll-like receptor (TLR) expression in inflammatory bowel disease (IBD) was first described 10 years ago. Since then, studies from many groups have led to the current concept that TLRs represent key mediators of innate host defense in the intestine, involved in maintaining mucosal as well as commensal homeostasis. Recent findings in diverse murine models of colitis have helped to reveal the mechanistic importance of TLR dysfunction in IBD pathogenesis. It has become evident that environment, genetics, and host immunity form a multidimensional and highly interactive regulatory triad that controls TLR function in the intestinal mucosa. Imbalanced relationships within this triad may promote aberrant TLR signaling, critically contributing to acute and chronic intestinal inflammatory processes in IBD colitis and associated cancer. (Inflamm Bowel Dis 2010)