Original Article

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IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo†

  1. Jonas Mudter MD1,‡,
  2. Jingling Yu MD2,‡,
  3. Christel Zufferey MD3,
  4. Anne Brüstle MD4,
  5. Stefan Wirtz MD1,
  6. Benno Weigmann MD1,
  7. Arthur Hoffman MD5,
  8. Mirjam Schenk MD4,
  9. Peter R. Galle MD3,
  10. Hans A. Lehr MD6,
  11. Christoph Mueller PhD3,
  12. Michael Lohoff MD4,
  13. Markus F. Neurath MD2,*

Article first published online: 8 FEB 2011

DOI: 10.1002/ibd.21476

Issue

Inflammatory Bowel Diseases

Inflammatory Bowel Diseases

Volume 17, Issue 6, pages 1343–1358, June 2011

Additional Information

How to Cite

Mudter, J., Yu, J., Zufferey, C., Brüstle, A., Wirtz, S., Weigmann, B., Hoffman, A., Schenk, M., Galle, P. R., Lehr, H. A., Mueller, C., Lohoff, M. and Neurath, M. F. (2011), IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo. Inflamm Bowel Dis, 17: 1343–1358. doi: 10.1002/ibd.21476

Author Information

  1. 1

    1st Medical Clinic, University of Erlangen, Germany

  2. 2

    Institute of Molecular Medicine, University of Mainz, Germany

  3. 3

    Institute of Pathology, University of Bern, Switzerland

  4. 4

    Institute of Medical Microbiology, University of Marburg, Germany

  5. 5

    1st Medical Clinic, University of Mainz, Germany

  6. 6

    Department of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

  1. ‡

    The first two authors contributed equally to the work.

*1st Department of Internal Medicine, University of Erlangen-Nürnberg, Germany

  1. †

    M.F.N and J.M. supported by a grant from the “Stiftung Rheinland-Pfalz für Innovation” and the Broad Foundation (Broad Medical Program). M.L. was supported by the DFG (SFB TR22) and by the LOEWE grant Tumor and Inflammation.

  2. ‡

    The first two authors contributed equally to the work.

Publication History

  1. Issue published online: 10 MAY 2011
  2. Article first published online: 8 FEB 2011
  3. Manuscript Accepted: 2 AUG 2010
  4. Manuscript Received: 30 JUL 2010

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