Specific author contributions: Stéphane Nahon: conception, design, collection and interpretation of data, and article preparation; Pierre Lahmek: statistical analysis and interpretation of data; Christelle Durance: data collection; Alain Olympie: conception and design; Catherine Saas: conception; Bruno Lesgourgues: interpretation of data; Jean-Pierre Gendre: interpretation of data and article preparation. All authors have reviewed and approved the final draft submitted.
Socioeconomic and psychological factors associated with nonadherence to treatment in inflammatory bowel disease patients: Results of the ISSEO survey†
Article first published online: 25 OCT 2010
Copyright © 2010 Crohn's & Colitis Foundation of America, Inc.
Inflammatory Bowel Diseases
Volume 17, Issue 6, pages 1270–1276, June 2011
How to Cite
Nahon, S., Lahmek, P., Saas, C., Durance, C., Olympie, A., Lesgourgues, B. and Gendre, J.-P. (2011), Socioeconomic and psychological factors associated with nonadherence to treatment in inflammatory bowel disease patients: Results of the ISSEO survey. Inflamm Bowel Dis, 17: 1270–1276. doi: 10.1002/ibd.21482
- Issue published online: 10 MAY 2011
- Article first published online: 25 OCT 2010
- Manuscript Accepted: 9 AUG 2010
- Manuscript Received: 1 JUN 2010
- ulcerative colitis;
- Crohn's disease;
Adherence to treatment is a key condition in preventing relapses in inflammatory bowel disease (IBD). The aims of this study were specifically to study socioeconomic and psychological factors and adherence to treatment in a large cohort of patients.
A questionnaire concerning demographic, clinical, and psychosocial characteristics was mailed to 6000 IBD patients belonging to the French association of IBD patients (AFA). The questionnaire was also available on the Website of the AFA for nonmember patients to answer. Good adherence to treatment was defined as taking ≥80% of prescribed medication. Socioeconomic deprivation was assessed using the specific EPICES score (http://www.cetaf.asso.fr) developed in France. Anxiety and depression were assessed using the Hospital Anxiety and Depression scale.
A total of 1069 women and 594 men (43.6 ± 15.4 years) completed the questionnaire; 1450 (87.2%) of them belonged to the AFA. In all, 1044 had Crohn's disease, 36 indeterminate colitis, and 583 ulcerative colitis. Adherence ≥80% was reported by 89.6% of patients. Factors associated with good adherence were: older age (P < 0.01), treatment with anti-tumor necrosis factor (TNF) (P < 0.0001), membership in the AFA (P = 0.006). Nonadherence increases with smoking (P = 0.02), constraints related to treatment (P < 10−9), anxiety (P < 10−6), and moodiness (P < 10−5). There were no differences in adherence for the following: gender, type of IBD, activity and severity of the disease, socioeconomic deprivation, marital status, education level, and depression.
In this large cohort of IBD patients, psychological distress and constraints related to treatment decrease adherence to treatment, while membership in a patients' association improves it. (Inflamm Bowel Dis 2011;)