SAMP1/YitFc mouse strain: A spontaneous model of Crohn's disease-like ileitis

Authors

  • Theresa T. Pizarro PhD,

    Corresponding author
    1. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio
    • Department of Pathology, Case Western Reserve University School of Medicine, 2103 Cornell Road, WRB 5534, Cleveland, OH 44106
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  • Luca Pastorelli MD,

    1. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio
    2. Gastroenterology & Gastrointestinal Endoscopy Unit, IRCCS Policlinico San Donato, San Donato Milanese and Department of Medical Science, University of Milan School of Medicine, Milan, Italy
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  • Giorgos Bamias MD,

    1. First Department of Propaedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
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  • Rekha R. Garg PhD,

    1. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio
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  • Brian K. Reuter PhD,

    1. Centre of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, Canada
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  • Joseph R. Mercado BA,

    1. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio
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  • Marcello Chieppa PhD,

    1. Department of Translational Medicine, National Institute of Gastroenterology, Bari, Italy
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  • Kristen O. Arseneau MS,

    1. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio
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  • Klaus Ley MD,

    1. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio
    2. Division of Inflammation Biology, La Jolla Institute of Allergy and Immunology, La Jolla, California
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  • Fabio Cominelli MD, PhD

    1. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio
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  • Supported by the National Institutes of Health, grant numbers: DK057880 (to T.T.P., K.L., and F.C.), DK056762 (to T.T.P.), DK042191 (to F.C. and T.T.P.), DK066880 (to F.C.), DK055812 (to F.C.); and the Crohn's & Colitis Foundation of America: Senior Investigator Award (to T.T.P.), Career Development Award (to B.K.R.), and Research Fellowship Awards (to G.B., K.O.A., and R.R.G.).

Abstract

The SAMP1/YitFc mouse strain represents a model of Crohn's disease (CD)-like ileitis that is ideal for investigating the pathogenesis of chronic intestinal inflammation. Different from the vast majority of animal models of colitis, the ileal-specific phenotype characteristic of SAMP1/YitFc mice occurs spontaneously, without genetic, chemical, or immunological manipulation. In addition, SAMP1/YitFc mice possess remarkable similarities to the human condition with regard to disease location, histologic features, incidence of extraintestinal manifestations, and response to conventional therapies. SAMP1/YitFc mice also display a well-defined time course of a predisease state and phases of acute and chronic ileitis. As such, the SAMP1/YitFc model is particularly suitable for elucidating pathways that precede the clinical phenotype that may lead to preventive, and therefore more efficacious, intervention with the natural course of disease, or alternatively, for the development of therapeutic strategies directed against chronic, established ileitis. In this review we summarize important contributions made by our group and others that uncover potential mechanisms in the pathogenesis of CD using this unique murine model of chronic intestinal inflammation. (Inflamm Bowel Dis 2011;)

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