Supported in part by the Ministry of Education, Culture, Sports, Science and Technology of Japan.
Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis†
Article first published online: 23 FEB 2011
Copyright © 2011 Crohn's & Colitis Foundation of America, Inc.
Inflammatory Bowel Diseases
Volume 17, Issue 12, pages 2407–2415, December 2011
How to Cite
Umeno, J., Asano, K., Matsushita, T., Matsumoto, T., Kiyohara, Y., Iida, M., Nakamura, Y., Kamatani, N. and Kubo, M. (2011), Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis. Inflamm Bowel Dis, 17: 2407–2415. doi: 10.1002/ibd.21651
- Issue published online: 9 NOV 2011
- Article first published online: 23 FEB 2011
- Manuscript Accepted: 17 DEC 2010
- Manuscript Received: 6 DEC 2010
- single nucleotide polymorphism;
- shared genetic risk;
- ulcerative colitis;
- Crohn's disease
Both ulcerative colitis (UC) and Crohn's disease (CD) have a complex etiology involving multiple genetic and environmental factors. Many genome-wide association studies (GWAS) and subsequent replication studies revealed that both diseases share some of the susceptibility loci; however, common genetic factors for both diseases are not fully elucidated. This study is aimed to identify the common genetic factors for CD and UC by a meta-analysis of published studies.
We first reviewed the 10 GWAS for CD to select candidate single nucleotide polymorphisms (SNPs). Next, we performed a PubMed literature search up to June 30, 2010 and carried out a systemic review of published studies that examined the association of CD susceptibility loci in UC patients. Meta-analysis was carried out using the inverse variance-weighted method or the DerSimonian-Laird method after estimating the heterogeneity among the studies. The data for highly linked SNPs were combined. Finally, we performed a meta-analysis of 43 published studies in 45 SNPs located at 33 loci by using a total of 4852 to 31,125 subjects.
We confirmed the association of 17 reported common susceptibility loci. Moreover, we found associations at eight additional loci: GCKR, ATG16L1, CDKAL1, ZNF365, LRRK2-MUC19, C13orf31, PTPN2, and SBNO2. The genetic risk of each locus was modest (odds ratios ranged from 1.05–1.22) except IL23R.
These results indicate that CD and UC share many susceptibility loci with small genetic effect. Our data provide further understanding of the common pathogenesis between CD and UC. (Inflamm Bowel Dis 2011)