Supported by grants from Copenhagen University, the Augustinus Foundation, Ville Heise Foundation, Sigrid Morans Foundation, and the Vibeke Binder and Poul Riis Foundation.
Pediatric inflammatory bowel disease: Increasing incidence, decreasing surgery rate, and compromised nutritional status: A prospective population-based cohort study 2007–2009†
Article first published online: 4 MAR 2011
Copyright © 2011 Crohn's & Crohn's & Colitis Foundation of America, Inc.
Inflammatory Bowel Diseases
Volume 17, Issue 12, pages 2541–2550, December 2011
How to Cite
Jakobsen, C., Paerregaard, A., Munkholm, P., Faerk, J., Lange, A., Andersen, J., Jakobsen, M., Kramer, I., Czernia-Mazurkiewicz, J. and Wewer, V. (2011), Pediatric inflammatory bowel disease: Increasing incidence, decreasing surgery rate, and compromised nutritional status: A prospective population-based cohort study 2007–2009. Inflamm Bowel Dis, 17: 2541–2550. doi: 10.1002/ibd.21654
- Issue published online: 9 NOV 2011
- Article first published online: 4 MAR 2011
- Manuscript Accepted: 23 DEC 2010
- Manuscript Received: 13 DEC 2010
- Copenhagen University
- Augustinus Foundation
- Ville Heise Foundation
- Sigrid Morans Foundation
- Vibeke Binder and Poul Riis Foundation
- inflammatory bowel disease;
- immunomodulatory therapy;
The aim was to evaluate the incidence, treatment, surgery rate, and anthropometry at diagnosis of children with inflammatory bowel disease (IBD).
Patients diagnosed between January 1, 2007 to December 31, 2009 in Eastern Denmark, Funen, and Aarhus were included from a background population of 668,056 children <15 years of age. For evaluation of incidence, treatment, and surgery rate, a subcohort from Eastern Denmark was extracted for comparison with a previously published population-based cohort from the same geographical area (1998–2006).
In all, 130 children with IBD: 65 with Crohn's disease (CD), 62 with ulcerative colitis (UC), and three with IBD unclassified (IBDU) were included. The mean incidence rates per 106 in 2007–2009 were: IBD: 6.4 (95% confidence interval [CI]: 5.4–7.7), CD: 3.2 (2.5–4.1), UC: 3.1 (2.4–4.0) and IBDU: 0.2 (0.05–0.5). Comparing the two cohorts from Eastern Denmark we found higher incidence rates for IBD (5.0 and 7.2 in 1998–2000 and 2007–2009, respectively, P = 0.02) and CD (2.3 versus 3.3, P = 0.04). Furthermore, we found a significant decrease in surgery rates (15.8/100 person-years versus 4.2, P = 0.02) and an increase in the rate of initiating immunomodulators (IM) within the first year (29.0/100 person-years versus 69.2, P < 0.001). IM use was associated with a trend towards a decreased surgery risk (relative risk [RR] 0.38; 0.15–1.0). Children with CD had poor nutritional status at diagnosis compared with the general pediatric population.
Over the past 12 years we found an increase in the incidence of IBD in children, an increasing use of IM, and decreasing 1-year surgery rates. CD patients had poor nutritional status. (Inflamm Bowel Dis 2011;)