Presented in part at the Annual Meeting of the American Gastroenterological Association, New Orleans, LA, May 1–5, 2010 (Gastroenterology 2010;138(5 suppl 1):S-199).
Article first published online: 23 FEB 2011
Copyright © 2011 Crohn's & Colitis Foundation of America, Inc.
Inflammatory Bowel Diseases
Volume 18, Issue 1, pages 43–48, January 2012
How to Cite
Peyrin-Biroulet, L., Loftus, E. V., Tremaine, W. J., Harmsen, W. S., Zinsmeister, A. R. and Sandborn, W. J. (2012), Perianal Crohn's disease findings other than fistulas in a population-based cohort. Inflamm Bowel Dis, 18: 43–48. doi: 10.1002/ibd.21674
Supported by the Mayo Foundation for Medical Education and Research, and made possible by the Rochester Epidemiology Project (Grant Number R01 AG034676 from the National Institute on Aging).
Peyrin-Biroulet: Study concept and design, acquisition of data, analysis and interpretation of data, drafting of the article. Loftus: Study concept and design, analysis, and interpretation of data, drafting of the article, critical revision of the article, obtaining funding, study supervision. Tremaine: Critical revision of the article. Harmsen: Analysis and interpretation of data, critical revision of the article. Zinsmeister: Analysis and interpretation of data, critical revision of the article. Sandborn: Study concept and design, critical revision of the article, obtaining funding.
- Issue published online: 11 DEC 2011
- Article first published online: 23 FEB 2011
- Manuscript Accepted: 12 JAN 2011
- Manuscript Received: 5 JAN 2011
- Crohn's disease;
- natural history;
- anorectal strictures;
- anal ulcers;
- perianal tags;
- anal fissures
The cumulative incidence of and risk factors for perianal Crohn's disease (CD) for findings other than fistulas are unknown.
The medical records of 310 incident cases of CD from Olmsted County, Minnesota, diagnosed between 1970 and 2004, were reviewed for evidence of perianal disease findings other than fistulas. Cumulative incidence was estimated using the Kaplan–Meier method, and associations between baseline factors and time to first event were assessed using proportional hazards regression. Four types of lesions were studied: anorectal strictures, deep anal canal ulcers, anal fissures, and perianal skin tags.
The 10-year cumulative probability from time of diagnosis was 5.8% (95% confidence interval [CI], 2.6%–8.8%) for anorectal strictures, 6.6% (3.6%–9.6%) for deep anal canal ulcers, 10.5% (6.8%–14.1%) for anal fissures, and 18.7% (13.9%–23.3%) for perianal skin tags. The cumulative probability for any perianal lesion other than fistulas was 21.3% (16.5%–25.8%) at 5 years and 29.2% (23.5%–34.5%) at 10 years. Baseline factors associated with time to first perianal lesion other than fistulas were age (hazard ratio [HR] per 10 years, 0.9; 95% CI, 0.8–0.98; P = 0.026), female gender (HR, 1.7; 95% CI, 1.1–2.7; P = 0.013), and presence of extraintestinal manifestations (HR, 1.7; 95% CI, 1.03–2.8; P = 0.038).
Perianal lesions other than fistulas occurred frequently during the clinical course of CD. Female gender and extraintestinal manifestations were associated with increased risks for perianal lesions other than fistulas, while older age at diagnosis was associated with a slightly decreased risk. (Inflamm Bowel Dis 2011)