P.H. and H.E.D. are funded by a Medical Research Council project grant for PICTS (G0800675). R.H. is funded by a fellowship from the Chief Scientist Office in Scotland (CAF/08/01). Further support has come from the GI-Nutrition Research Fund, Child Life and Health, University of Edinburgh. The IBD team at Yorkhill, Glasgow is supported by the Catherine McEwan Foundation.
Rising incidence of pediatric inflammatory bowel disease in Scotland†
Article first published online: 17 JUN 2011
Copyright © 2011 Crohn's & Colitis Foundation of America, Inc.
Inflammatory Bowel Diseases
Volume 18, Issue 6, pages 999–1005, June 2012
How to Cite
Henderson, P., Hansen, R., Cameron, F. L., Gerasimidis, K., Rogers, P., Bisset, W. M., Reynish, E. L., Drummond, H. E., Anderson, N. H., Van Limbergen, J., Russell, R. K., Satsangi, J. and Wilson, D. C. (2012), Rising incidence of pediatric inflammatory bowel disease in Scotland. Inflamm Bowel Dis, 18: 999–1005. doi: 10.1002/ibd.21797
- Issue published online: 17 MAY 2012
- Article first published online: 17 JUN 2011
- Manuscript Accepted: 16 MAY 2011
- Manuscript Received: 27 APR 2011
- inflammatory bowel diseases;
- Crohn's disease;
- ulcerative colitis;
An accurate indication of the changing incidence of pediatric inflammatory bowel disease (PIBD) within a population is useful in understanding concurrent etiological factors. We aimed to compare the current incidence and other demographic attributes of PIBD in the Scottish population to previous data.
A national cohort of prospectively and retrospectively acquired incident cases of PIBD diagnosed less than 16 years old in pediatric services in Scotland was captured for the period 2003–2008; historical Scottish data were used for comparison (1990–1995). Age/sex-adjusted incidences were calculated and statistical comparisons made using Poisson regression.
During the 2003–2008 study period 436 patients were diagnosed with PIBD in Scotland, giving an adjusted incidence of 7.82/100,000/year. The incidence of Crohn's disease (CD) was 4.75/100,000/year, ulcerative colitis (UC) 2.06/100,000/year, and inflammatory bowel disease-unclassified (IBDU) 1.01/100,000/year. Compared with data from 1990–1995 when 260 IBD patients were diagnosed, significant rises in the incidence of IBD (from 4.45/100,000/year, P < 0.0001), CD (from 2.86/100,000/year, P < 0.0001), and UC (from 1.59/100,000/year, P = 0.023) were seen. There was also a significant reduction in the median age at IBD diagnosis from 12.7 years to 11.9 years between the periods (P = 0.003), with a continued male preponderance.
The number of Scottish children diagnosed with IBD continues to rise, with a statistically significant 76% increase since the mid-1990s. Furthermore, PIBD is now being diagnosed at a younger age. The reason for this continued rise is not yet clear; however, new hypotheses regarding disease pathogenesis and other population trends may provide further insights in future years. (Inflamm Bowel Dis 2012;)