SEARCH

SEARCH BY CITATION

REFERENCES

  • 1
    Caprilli R, Gassull MA, Escher JC, et al. European evidence based consensus on the diagnosis and management of Crohn's disease: special situations. Gut. 2006; 55( suppl 1): i3658.
  • 2
    Chardavoyne R, Flint GW, Pollack S, et al. Factors affecting recurrence following resection for Crohn's disease. Dis Colon Rectum. 1986; 29: 495502.
  • 3
    Lock MR, Farmer RG, Fazio VW, et al. Recurrence and reoperation for Crohn's disease: the role of disease location in prognosis. N Engl J Med. 1981; 304: 15861588.
  • 4
    Bernell O, Lapidus A, Hellers G. Risk factors for surgery and postoperative recurrence in Crohn's disease. Ann Surg. 2000; 231: 3845.
  • 5
    Landsend E, Johnson E, Johannessen H-O, et al. Long-term outcome after intestinal resection for Crohn's disease. Scand J Gastroenterol. 2006; 41: 12041208.
  • 6
    Cosnes J, Nion-Larmurier I, Beaugerie L, et al. Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery. Gut. 2005; 54: 237241.
  • 7
    Delaney CP, Kiran RP, Senagore AJ, et al. Quality of life improves within 30 days of surgery for Crohn's disease. J Am Coll Surg. 2003; 196: 714721.
  • 8
    Rutgeerts P, Geboes K, Vantrappen G, et al. Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery. Gut. 1984; 25: 665672.
  • 9
    Rutgeerts P, Geboes K, Vantrappen G, et al. Predictability of the postoperative course of Crohn's disease. Gastroenterology. 1990; 99: 956963.
  • 10
    Olaison G, Smedh K, Sjödahl R. Natural course of Crohn's disease after ileocolic resection: endoscopically visualised ileal ulcers preceding symptoms. Gut. 1992; 33: 331335.
  • 11
    Renna S, Cammà C, Modesto I, et al. Meta-analysis of the placebo rates of clinical relapse and severe endoscopic recurrence in postoperative Crohn's disease. Gastroenterology. 2008; 135: 15001509.
  • 12
    Michelassi F, Balestracci T, Chappell R, et al. Primary and recurrent Crohn's disease. Experience with 1379 patients. Ann Surg. 1991; 214: 230.
  • 13
    Rutgeerts P. Protagonist: Crohn's disease recurrence can be prevented after ileal resection. Gut. 2002; 51: 152153.
  • 14
    Pascua M, Su C, Lewis JD, et al. Meta-analysis: factors predicting post-operative recurrence with placebo therapy in patients with Crohn's disease. Aliment Pharmacol Ther. 2008; 28: 545556.
  • 15
    Yamamoto T. Factors affecting recurrence after surgery for Crohn's disease. World J Gastroenterol. 2005; 11: 39713979.
  • 16
    Binder V, Hendriksen C, Kreiner S. Prognosis in Crohn's disease—based on results from a regional patient group from the county of Copenhagen. Gut. 1985; 26: 146150.
  • 17
    Goldberg PA, Wright JP, Gerber M, et al. Incidence of surgical resection for Crohn's disease. Dis Colon Rectum. 1993; 36: 736739.
  • 18
    Sachar DB. Patterns of postoperative recurrence in Crohn's disease. Scand J Gastroenterol Supplement. 1990; 172: 3538.
  • 19
    Greenstein AJ, Sachar DB, Pasternack BS, et al. Reoperation and recurrence in Crohn's colitis and ileocolitis crude and cumulative rates. N Engl J Med. 1975; 293: 685690.
  • 20
    Nygaard K, Fausa O. Crohn's disease. Recurrence after surgical treatment. Scand J Gastroenterol. 1977; 12: 577584.
  • 21
    Whelan G, Farmer RG, Fazio VW, et al. Recurrence after surgery in Crohn's disease. Relationship to location of disease (clinical pattern) and surgical indication. Gastroenterology. 1985; 88: 18261833.
  • 22
    Yamamoto T, Allan RN, Keighley MR. Long-term outcome of surgical management for diffuse jejunoileal Crohn's disease. Surgery. 2001; 129: 96102.
  • 23
    Larson DW, Pemberton JH. Current concepts and controversies in surgery for IBD. Gastroenterology. 2004; 126: 16111619.
  • 24
    Rutgeerts P, Goboes K, Peeters M, et al. Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum. Lancet. 1991; 338: 771774.
  • 25
    Terdiman JP. Prevention of postoperative recurrence in Crohn's disease. Clin Gastroenterol Hepatol. 2008; 6: 616620.
  • 26
    Onali S, Petruzziello C, Calabrese E, et al. Frequency, pattern, and risk factors of postoperative recurrence of Crohn's disease after resection different from ileo-colonic. J Gastrointest Surg. 2009; 13: 246252.
  • 27
    Lautenbach E, Berlin JA, Lichtenstein GR. Risk factors for early postoperative recurrence of Crohn's disease. Gastroenterology. 1998; 115: 259267.
  • 28
    Avidan B, Sakhnini E, Lahat A, et al. Risk factors regarding the need for a second operation in patients with Crohn's disease. Digestion. 2005; 72: 248253.
  • 29
    Baldassano RN, Han PD, Jeshion WC, et al. Pediatric Crohn's disease: risk factors for postoperative recurrence. Am J Gastroenterol. 2001; 96: 21692176.
  • 30
    Hofer B, Böttger T, Hernandez-Richter T, et al. The impact of clinical types of disease manifestation on the risk of early postoperative recurrence in Crohn's disease. Hepato-Gastroenterology. 2001; 48: 152155.
  • 31
    Griffiths AM, Wesson DE, Shandling B, et al. Factors influencing postoperative recurrence of Crohn's disease in childhood. Gut. 1991; 32: 491495.
  • 32
    Fielding JF. Risk factors for postoperative recurrence of Crohn's disease. Gastroenterology. 1984; 87: 12071208.
  • 33
    Unkart JT, Anderson L, Li E, et al. Risk factors for surgical recurrence after ileocolic resection of Crohn's disease. Dis Colon Rectum. 2008; 51: 12111216.
  • 34
    Martin G, Heyen F, Dube S. [Factors of recurrence in Crohn disease.] Ann Chir. 1994; 48: 685690.
  • 35
    Sachar DB, Wolfson DM, Greenstein AJ, et al. Risk factors for postoperative recurrence of Crohn's disease. Gastroenterology. 1983; 85: 917921.
  • 36
    Softley A, Myren J, Clamp SE, et al. Factors affecting recurrence after surgery for Crohn's disease. Scand J Gastroenterol Supplement. 1988; 144: 3134.
  • 37
    Scarpa M, Angriman I, Barollo M, et al. Risk factors for recurrence of stenosis in Crohn's disease. Acta Biomed. 2003; 74 Suppl 2: 8083.
  • 38
    Poggioli G, Laureti S, Selleri S, et al. Factors affecting recurrence in Crohn's disease. Results of a prospective audit. Int J Colorectal Dis. 1996; 11: 294298.
  • 39
    Lindberg E, Jarnerot G, Huitfeldt B. Smoking in Crohn's disease: effect on localisation and clinical course. Gut. 1992; 33: 779782.
  • 40
    Yamamoto T, Keighley MR. Smoking and disease recurrence after operation for Crohn's disease. Br J Surg. 2000; 87: 398404.
  • 41
    Yamamoto T, Allan RN, Keighley MR. Smoking is a predictive factor for outcome after colectomy and ileorectal anastomosis in patients with Crohn's colitis. Br J Surg. 1999; 86: 10691070.
  • 42
    Yamamoto T, Keighley MR. The association of cigarette smoking with a high risk of recurrence after ileocolonic resection for ileocecal Crohn's disease. Surg Today. 1999; 29: 579580.
  • 43
    Reese GE, Nanidis T, Borysiewicz C, et al. The effect of smoking after surgery for Crohn's disease: a meta-analysis of observational studies. Int J Colorectal Dis. 2008; 23: 12131221.
  • 44
    Ryan WR, Allan RN, Yamamoto T, et al. Crohn's disease patients who quit smoking have a reduced risk of reoperation for recurrence. Am J Surg. 2004; 187: 219225.
  • 45
    Cosnes J, Beaugerie L, Carbonnel F, et al. Smoking cessation and the course of Crohn's disease: an intervention study. Gastroenterology. 2001; 120: 10931099.
  • 46
    Cottone M, Rosselli M, Orlando A, et al. Smoking habits and recurrence in Crohn's disease. Gastroenterology. 1994; 106: 643648.
  • 47
    Timmer A, Sutherland LR, Martin F. Oral contraceptive use and smoking are risk factors for relapse in Crohn's disease. The Canadian Mesalamine for Remission of Crohn's Disease Study Group. Gastroenterology. 1998; 114: 11431150.
  • 48
    Medina C, Vergara M, Casellas F, et al. Influence of the smoking habit in the surgery of inflammatory bowel disease. Rev Esp Enferm Dig. 1998; 90: 771778.
  • 49
    Kyle J. Prognosis after ileal resection for Crohn's disease. Br J Surg. 1971; 58: 735737.
  • 50
    Lennard Jones JE, Stalder GA. Prognosis after resection of chronic regional ileitis. Gut. 1971; 8: 332336.
  • 51
    Ellis L, Calhoun P, Kaiser DL, et al. Postoperative recurrence in Crohn's disease. The effect of the initial length of bowel resection and operative procedure. Ann Surg. 1984; 199: 340347.
  • 52
    Wettergren A, Christiansen J. Risk of recurrence and reoperation after resection for ileocolic Crohn's disease. Scand J Gastroenterol. 1991; 26: 13191322.
  • 53
    Caprilli R, Corrao G, Taddei G, et al. Prognostic factors for postoperative recurrence of Crohn's disease. Gruppo Italiano per lo Studio del Colon e del Retto (GISC). Dis Colon Rectum. 1996; 39: 335341.
  • 54
    Raab Y, Bergström R, Ejerblad S, et al. Factors influencing recurrence in Crohn's disease. An analysis of a consecutive series of 353 patients treated with primary surgery. Dis Colon Rectum. 1996; 39: 918925.
  • 55
    Post S, Herfarth C, Bohm E, et al. The impact of disease pattern, surgical management, and individual surgeons on the risk for relaparotomy for recurrent Crohn's disease. Ann Surg. 1996; 223: 253260.
  • 56
    Anseline PF, Wlodarczyk J, Murugasu R. Presence of granulomas is associated with recurrence after surgery for Crohn's disease: experience of a surgical unit. Br J Surg. 1997; 84: 7882.
  • 57
    Kurer MA, Stamou KM, Wilson TR, et al. Early symptomatic recurrence after intestinal resection in Crohn's disease is unpredictable. Colorectal Dis. 2007; 9: 567571.
  • 58
    Beaugerie L, Seksik P, Nion-Larmurier I, et al. Predictors of Crohn's disease. Gastroenterology. 2006; 130: 650656.
  • 59
    Loly C, Belaiche J, Louis E. Predictors of severe Crohn's disease. Scand J Gastroenterol. 2008; 43: 948954.
  • 60
    De Dombal FT, Burton I, Goligher JC. Recurrence of Crohn's disease after primary excisional surgery. Gut. 1971; 12: 519527.
  • 61
    Yamamoto T, Bain IM, Allan RN, et al. Risk factors for anastomotic recurrence after ileocolonic resection for Crohn's disease: the importance of smoking. Gastroenterology. 1998; 114.
  • 62
    Shivananda S, Lennard-Jones J, Logan R, et al. Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD). Gut. 1996; 39: 690697.
  • 63
    Shivananda S, Hordijk ML, Pena AS, et al. Crohn's disease: risk of recurrence and reoperation in a defined population. Gut. 1989; 30: 990995.
  • 64
    Ng SC, Lied GA, Arebi N, et al. Clinical and surgical recurrence of Crohn's disease after ileocolonic resection in a specialist unit. Eur J Gastrolenterol Hepatol. 2009; 21: 551557.
  • 65
    McLeod RS, Wolff BG, Ross S, et al. Recurrence of Crohn's disease after ileocolic resection is not affected by anastomotic type: results of a multicenter, randomized, controlled trial. Dis Colon Rectum. 2009; 52: 919927.
  • 66
    Ardizzone S, Maconi G, Sampietro GM, et al. Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn's disease. Gastroenterology. 2004; 127: 730740.
  • 67
    Wolff BG. Factors determining recurrence following surgery for Crohn's disease. World J Surg. 1998; 22: 364369.
  • 68
    Scarpa M, Ruffolo C, Bertin E, et al. Surgical predictors of recurrence of Crohn's disease after ileocolonic resection. Int J Colorectal Dis. 2007; 22: 10611069.
  • 69
    Borley NR, Mortensen NJM, Chaudry MA, et al. Recurrence after abdominal surgery for Crohn's disease: relationship to disease site and surgical procedure. Dis Colon Rectum. 2002; 45: 377383.
  • 70
    Wolters FL, Russel MG, Sijbrandij J, et al. Phenotype at diagnosis predicts recurrence rates in Crohn's disease. Gut. 2006; 55: 11241130.
  • 71
    Keh C, Shatari T, Yamamoto T, et al. Jejunal Crohn's disease is associated with a higher postoperative recurrence rate than ileocaecal Crohn's disease. Colorectal Dis. 2005; 7: 366368.
  • 72
    Aeberhard P, Berchtold W, Riedtmann HJ, et al. Surgical recurrence of perforating and nonperforating Crohn's disease. A study of 101 surgically treated Patients. Dis Colon Rectum. 1996; 39: 8087.
  • 73
    Simillis C, Yamamoto T, Reese GE, et al. A meta-analysis comparing incidence of recurrence and indication for reoperation after surgery for perforating versus nonperforating Crohn's disease. Am J Gastroenterol. 2008; 103: 196205.
    Direct Link:
  • 74
    Sachar DB, Lemmer E, Ibrahim C, et al. Recurrence patterns after first resection for stricturing or penetrating Crohn's disease. Inflamm Bowel Dis. 2009; 15: 10711075.
  • 75
    Mirow L, Hauenschild L, Hildebrand P, et al. [Recurrence of Crohn's disease after surgery—causes and risks.] Zentralbl Chir. 2008; 133: 182187.
  • 76
    Silverberg MS, Satsangi J, Ahmad T. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol. 2005; 19: 536.
  • 77
    Pallone F, Boirivant M, Stazi MA, et al. Analysis of clinical course of postoperative recurrence in Crohn's disease of distal ileum. Dig Dis Sci. 1992; 37: 215219.
  • 78
    Greenstein AJ, Lachman P, Sachar DB, et al. Perforating and non-perforating indications for repeated operations in Crohn's disease: evidence for two clinical forms. Gut. 1988; 29: 588592.
  • 79
    Yamamoto T, Allan RN, Keighley MR. Perforating ileocecal Crohn's disease does not carry a high risk of recurrence but usually re-presents as perforating disease. Dis Colon Rectum. 1999; 42: 519524.
  • 80
    McDonald PJ, Fazio VW, Farmer RG, et al. Perforating and nonperforating Crohn's disease. An unpredictable guide to recurrence after surgery. Dis Colon Rectum. 1989; 32: 117120.
  • 81
    Hamilton SR, Boitnott JK, Morson BC. Relationships of disease extent and margin lengths to recurrence of Crohn's disease after ileocolonic anastomosis. Gastroenterology. 1981; 80.
  • 82
    Schofield PF. The natural history and treatment of Crohn's disease. Ann R Coll Surg Engl. 1965; 36: 258279.
  • 83
    Atwell JD, Duthie HL, Goligher JC. The outcome of Crohn's disease. Br J Surg. 1965; 52: 966972.
  • 84
    D'Haens GR, Gasparaitis AE, Hanauer SB. Duration of recurrent ileitis after ileocolonic resection correlates with presurgical extent of Crohn's disease. Gut. 1995; 36: 715717.
  • 85
    Trnka YM, Glotzer DJ, Kasdon EJ, et al. The long-term outcome of restorative operation in Crohn's disease: influence of location, prognostic factors and surgical guidelines. Ann Surg. 1982; 196: 345355.
  • 86
    Eshuis EJ, Bemelman WA, van Bodegraven AA, et al. Laparoscopic ileocolic resection versus infliximab treatment of distal ileitis in Crohn's disease: a randomized multicenter trial (LIR!C-trial). BMC Surg. 2008; 8: 15.
  • 87
    Buning C, Genschel J, Buhner S, et al. Mutations in the NOD2/CARD15 gene in Crohn's disease are associated with ileocecal resection and are a risk factor for reoperation. Aliment Pharmacol Ther. 2004; 19: 10731078.
  • 88
    Alvarez-Lobos M, Arostegui JI, Sans M, et al. Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence. Ann Surg. 2005; 242: 693700.
  • 89
    Maconi G, Colombo E, Sampietro GM, et al. CARD15 gene variants and risk of reoperation in Crohn's disease patients. Am J Gastroenterol. 2009; 104: 24832491.
  • 90
    Gorbe E, Chen J, Reimers MA. NOD2 risk alleles combined with habitual cigarette smoking accelerate the time to second ileocolic resection in Crohn's disease. Gastroenterology. 2009; 136.
  • 91
    Stone CD, Chen J, Unkart JT. Serology testing, genotype, and other risk factors for repeat ileocolic resection in Crohn's disease: a time-to-event analysis. Gastroenterology. 2008; 134.
  • 92
    Renda MC, Orlando A, Civitavecchia G, et al. The role of CARD15 mutations and smoking in the course of Crohn's disease in a Mediterranean area. Am J Gastroenterol. 2008; 103: 649655.
    Direct Link:
  • 93
    Newman B, Silverberg MS, Gu X, et al. CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease. Am J Gastroenterol. 2004; 99: 306315.
    Direct Link:
  • 94
    Mow WS, Vasiliauskas EA, Lin YC, et al. Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease. Gastroenterology. 2004; 126: 414424.
  • 95
    Targan SR, Landers CJ, Yang H, et al. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology. 2005; 128: 20202028.
  • 96
    Ruemmele FM, Targan SR, Levy G, et al. Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease. Gastroenterology. 1998; 115: 822829.
  • 97
    Eser A, Papay P, Miehsier W, et al. S1097 - Impact of intestinal resection on and prognostic value of Anti-Saccharomyces Cerevisiae serology in patients with Crohn's disease during long-term follow-up. Gastroenterology. 2009; 136( Suppl 1) A188.
  • 98
    Rieder F, Schleder S, Wolf A, et al. Association of the novel serologic anti-glycan antibodies anti-laminarin and anti-chitin with complicated Crohn's disease behavior. Inflamm Bowel Dis.. 2010; 16 263274.
  • 99
    McGovern DP, Taylor KD, Landers CJ. Clinical, serological and genetic predicators of postoperative recurrence in a single-center prospectively collected cohort of Crohn's disease patients. Gastroenterology. 2008; 134.
  • 100
    Cullen G, O'Toole A, Keegan D, et al. Long-term clinical results of ileocecal resection for Crohn's disease. Inflamm Bowel Dis. 2007; 13: 13691373.
  • 101
    Glass RE, Baker WN. Role of the granuloma in recurrent Crohn's disease. Gut. 1976; 17: 7577.
  • 102
    Chambers TJ, Morson BC. The granuloma in Crohn's disease. Gut. 1979; 20: 269274.
  • 103
    Simillis C, Jacovides M, Reese GE, et al. Meta-analysis of the role of granulomas in the recurrence of Crohn disease. Dis Colon Rectum. 2010; 53: 177185.
  • 104
    Ferrante M, de Hertogh G, Hlavaty T, et al. The value of myenteric plexitis to predict early postoperative Crohn's disease recurrence. Gastroenterology. 2006; 130: 15951606.
  • 105
    Sokol H, Polin V, Lavergne-Slove A, et al. Plexitis as a predictive factor of early postoperative clinical recurrence in Crohn's disease. Gut. 2009; 58: 12181225.
  • 106
    Ng SC, Lied GA, Kamm MA, et al. Predictive value and clinical significance of myenteric plexitis in Crohn's disease. Inflamm Bowel Dis. 2009; 15: 14991507.
  • 107
    Tan JJY, Tjandra JJ. Laparoscopic surgery for Crohn's disease: a meta-analysis. Dis Colon Rectum. 2007; 50: 576585.
  • 108
    Tilney HS, Constantinides VA, Heriot AG, et al. Comparison of laparoscopic and open ileocecal resection for Crohn's disease: a metaanalysis. Surg Endosc. 2006; 20: 10361044.
  • 109
    Sica GS, Iaculli E, Benavoli D, et al. Laparoscopic versus open ileo-colonic resection in Crohn's disease: short- and long-term results from a prospective longitudinal study. J Gastrointest Surg. 2008; 12: 109410102.
  • 110
    Bergamaschi R, Haughn C, Reed JF 3rd, et al. Laparoscopic intracorporeal ileocolic resection for Crohn's disease: is it safe? Dis Colon Rectum. 2009; 52: 651656.
  • 111
    Eshuis EJ, Polle SW, Slors JF, et al. Long-term surgical recurrence, morbidity, quality of life, and body image of laparoscopic-assisted vs. open ileocolic resection for Crohn's disease: a comparative study. Dis Colon Rectum. 2008; 51: 858867.
  • 112
    Lowney JK, Dietz DW, Birnbaum EH, et al. Is there any difference in recurrence rates in laparoscopic ileocolic resection for Crohn's disease compared with conventional surgery? A long-term, follow-up study. Dis Colon Rectum. 2006; 49: 5863.
  • 113
    Tabet J, Hong D, Kim CW, et al. Laparoscopic versus open bowel resection for Crohn's disease. Can J Gastroenterol. 2001; 15: 237242.
  • 114
    Milsom JW, Hammerhofer KA, Böhm B, et al. Prospective, randomized trial comparing laparoscopic vs. conventional surgery for refractory ileocolic Crohn's disease. Dis Colon Rectum. 2001; 44: 1.
  • 115
    Stocchi L, Milsom JW, Fazio VW. Long-term outcomes of laparoscopic versus open ileocolic resection for Crohn's disease: follow-up of a prospective randomized trial. Surgery. 2008; 144: 622.
  • 116
    Maartense S, Dunker MS, Slors JFM, et al. Laparoscopic-assisted versus open ileocolic resection for Crohn's disease: a randomized trial. Ann Surg. 2006; 243: 143.
  • 117
    Dasari BV, McKay D, Gardiner K. Laparoscopic versus open surgery for small bowel Crohn's disease. Cochrane Database Syst Rev. 2011: CD006956.
  • 118
    Hildebrandt U, Kessler K, Plusczyk T, et al. Comparison of surgical stress between laparoscopic and open colonic resections. Surg Endosc. 2003; 17: 242246.
  • 119
    Whelan RL, Franklin M, Holubar SD, et al. Postoperative cell mediated immune response is better preserved after laparoscopic vs open colorectal resection in humans. Surg Endosc. 2003; 17: 972978.
  • 120
    Alexander-Williams J, ed. Small bowel Crohn's disease. 2nd ed. Edinburgh: Churchill Livingstone; 1990.
  • 121
    Borley NR, Mortensen NJ, Jewell DP. Preventing postoperative recurrence of Crohn's disease. Br J Surg. 1997; 84: 14931502.
  • 122
    Hashemi M, Novell JR, Lewis AA. Side-to-side stapled anastomosis may delay recurrence in Crohn's disease. Dis Colon Rectum. 1998; 41: 12931296.
  • 123
    Munoz-Juarez M, Yamamoto T, Wolff BG, et al. Wide-lumen stapled anastomosis vs. conventional end-to-end anastomosis in the treatment of Crohn's disease. Dis Colon Rectum. 2001; 44: 2025; discussion 5–6.
  • 124
    Yamamoto T, Bain IM, Mylonakis E, et al. Stapled functional end-to-end anastomosis versus sutured end-to-end anastomosis after ileocolonic resection in Crohn disease. Scand J Gastroenterol. 1999; 34: 708713.
  • 125
    Bordeianou L, Dursun A. Current thinking on recurrence: does anastomotic surgical technique affect recurrence rates in Crohn's patients? Inflamm Bowel Dis. 2010; 16: 539540.
  • 126
    Ikeuchi H, Kusunoki M, Yamamura T. Long-term results of stapled and hand-sewn anastomoses in patients with Crohn's disease. Dig Surg. 2000; 17: 493496.
  • 127
    Tersigni R, Alessandroni L, Barreca M, et al. Does stapled functional end-to-end anastomosis affect recurrence of Crohn's disease after ileocolonic resection? Hepatogastroenterology. 2003; 50: 14221425.
  • 128
    Scott NA, Sue-Ling HM, Hughes LE. Anastomotic configuration does not affect recurrence of Crohn's disease after ileocolonic resection. Int J Colorectal Dis. 1995; 10: 6769.
  • 129
    Cameron JL, Hamilton SR, Coleman J, et al. Patterns of ileal recurrence in Crohn's disease. A prospective randomized study. Ann Surg. 1992; 215: 546551; discussion 51–52.
  • 130
    Krause U, Ejerblad S, Bergman L. Crohn's disease. A long-term study of the clinical course in 186 patients. Scand J Gastroenterol. 1985; 20: 516524.
  • 131
    Lindhagen T, Ekelund G, Leandoer L, et al. Recurrence rate after surgical treatment of Crohn's disease. Scand J Gastroenterol. 1983; 18: 10371044.
  • 132
    Karesen R, Serch-Hanssen A, Thoresen BO, et al. Crohn's disease: long-term results of surgical treatment. Scand J Gastroenterol. 1981; 16: 5764.
  • 133
    Wolff BG, Beart RW Jr, Frydenberg HB, et al. The importance of disease-free margins in resections for Crohn's disease. Dis Colon Rectum. 1983; 26: 239243.
  • 134
    Bergman L, Krause U. Crohn's disease. A long-term study of the clinical course in 186 patients. Scand J Gastroenterol. 1977; 12: 937944.
  • 135
    Speranza V, Simi M, Leardi S, et al. Recurrence of Crohn's disease after resection. Are there any risk factors? J Clin Gastroenterol. 1986; 8: 640646.
  • 136
    Pennington L, Hamilton SR, Bayless TM, et al. Surgical management of Crohn's disease. Influence of disease at margin of resection. Ann Surg. 1980; 192: 311318.
  • 137
    Fazio VW, Marchetti F, Church M, et al. Effect of resection margins on the recurrence of Crohn's disease in the small bowel. A randomized controlled trial. Ann Surg. 1996; 224: 563571; discussion 71–73.
  • 138
    Kotanagi H, Kramer K, Fazio VW, et al. Do microscopic abnormalities at resection margins correlate with increased anastomotic recurrence in Crohn's disease? Retrospective analysis of 100 cases. Dis Colon Rectum. 1991; 34: 909916.
  • 139
    Botti F, Carrara A, Antonelli B, et al. [The minimal bowel resection in Crohn's disease: analysis of prognostic factors on the surgical recurrence.] Ann Ital Chir. 2003; 74: 627633.
  • 140
    Martel P, Betton PO, Gallot D, et al. Crohn's colitis: experience with segmental resections; results in a series of 84 patients. J Am Coll Surg. 2002; 194: 448453.
  • 141
    Adloff M, Arnaud JP, Ollier JC. Does the histologic appearance at the margin of resection affect the postoperative recurrence rate in Crohn's disease? Am Surg. 1987; 53: 543546.
  • 142
    Dehn TC, Kettlewell MG, Mortensen NJ, et al. Ten-year experience of strictureplasty for obstructive Crohn's disease. Br J Surg. 1989; 76: 339341.
  • 143
    Fazio VW, Tjandra JJ. Strictureplasty for Crohn's disease with multiple long strictures. Dis Colon Rectum. 1993; 36: 7172.
  • 144
    Fazio VW, Tjandra JJ, Lavery IC, et al. Long-term follow-up of strictureplasty in Crohn's disease. Dis Colon Rectum. 1993; 36: 355361.
  • 145
    Tjandra JJ, Fazio VW. Strictureplasty for ileocolic anastomotic strictures in Crohn's disease. Dis Colon Rectum. 1993; 36: 10991103; discussion 103–104.
  • 146
    Spencer MP, Nelson H, Wolff BG, et al. Strictureplasty for obstructive Crohn's disease: the Mayo experience. Mayo Clin Proc. 1994; 69: 3336.
  • 147
    Stebbing JF, Jewell DP, Kettlewell MG, et al. Recurrence and reoperation after strictureplasty for obstructive Crohn's disease: long-term results [corrected]. Br J Surg. 1995; 82: 14711474.
  • 148
    Hurst RD, Michelassi F. Strictureplasty for Crohn's disease: techniques and long-term results. World J Surg. 1998; 22: 359363.
  • 149
    Yamamoto T, Bain IM, Allan RN, et al. An audit of strictureplasty for small-bowel Crohn's disease. Dis Colon Rectum. 1999; 42: 797803.
  • 150
    Dietz DW, Laureti S, Strong SA, et al. Safety and longterm efficacy of strictureplasty in 314 patients with obstructing small bowel Crohn's disease. J Am Coll Surg. 2001; 192: 330.
  • 151
    Yamamoto T, Fazio VW, Tekkis PP. Safety and efficacy of strictureplasty for Crohn's disease: a systematic review and meta-analysis. Dis Colon Rectum. 2007; 50: 19681986.
  • 152
    Williams JG, Hughes LE. Effect of perioperative blood transfusion on recurrence of Crohn's disease. Lancet. 1989; 2: 1524.
  • 153
    Peters WR, Fry RD, Fleshman JW, Kodner IJ. Multiple blood transfusions reduce the recurrence rate of Crohn's disease. Dis Colon Rectum. 1989; 32: 749753.
  • 154
    Gooszen HG, Silvis R. Protective effect of blood transfusions on postoperative recurrence of Crohn's disease in parous women. Neth J Med. 1994; 45: 6571.
  • 155
    Makowiec F, Loble M, Jenss H, et al. [Do perioperative blood transfusions affect the postoperative recurrence rate in Crohn disease?] Z Gastroenterol. 1992; 30: 2023.
  • 156
    Post S, Kunhardt M, Sido B, et al. [Effect of blood transfusions on rate of recurrence of Crohn disease.] Chirurg. 1992; 63: 3538.
  • 157
    Scott AD, Ritchie JK, Phillips RK. Blood transfusion and recurrent Crohn's disease. Br J Surg. 1991; 78: 455458.
  • 158
    Steup WH, Brand A, Weterman IT, et al. The effect of perioperative blood transfusion on recurrence after primary operation for Crohn's disease. Scand J Gastroenterol Supplement. 1991; 188: 8186.
  • 159
    Hollaar GL, Gooszen HG, Post S, et al. Perioperative blood transfusion does not prevent recurrence in Crohn's disease. A pooled analysis. J Clin Gastroenterol. 1995; 21: 134138.
  • 160
    Holzheimer RG, Molloy RG, Wittmann DH. Postoperative complications predict recurrence of Crohn's disease. Eur J Surg Acta Chirurg. 1995; 161: 129135.
  • 161
    Van Assche G, Dignass A, Panes J, et al. The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis. J Crohns Colitis. 2010; 4: 727.
  • 162
    Viscido A, Corrao G, Taddei G, et al. “Crohn's disease activity index” is inaccurate to detect the post-operative recurrence in Crohn's disease. A GISC study. Gruppo Italiano per lo Studio del Colon e del Retto. Ital J Gastroenterol Hepatol. 1999; 31: 274279.
  • 163
    Regueiro M, Schraut W, Baidoo L, et al. Infliximab prevents Crohn's disease recurrence after ileal resection. Gastroenterology. 2009; 136: 441450e1; quiz 716.
  • 164
    Walters TD, Steinhart AH, Bernstein CN, et al. Validating Crohn's disease activity indices for use in assessing postoperative recurrence. Inflamm Bowel Dis. 2011; 17: 15471556.
  • 165
    Tytgat GN, Mulder CJ, Brummelkamp WH. Endoscopic lesions in Crohn's disease early after ileocecal resection. Endoscopy. 1988; 20: 260262.
  • 166
    Olaison G, Smedh K, Sjodahl R. Natural course of Crohn's disease after ileocolic resection: endoscopically visualised ileal ulcers preceding symptoms. Gut. 1992; 33: 331335.
  • 167
    Caprilli R, Andreoli A, Capurso L, et al. Oral mesalazine (5-aminosalicylic acid; Asacol) for the prevention of post-operative recurrence of Crohn's disease. Gruppo Italiano per lo Studio del Colon e del Retto (GISC). Aliment Pharmacol Ther. 1994; 8: 3543.
  • 168
    Rutgeerts P, Van Assche G. What is the role of endoscopy in the postoperative management of Crohn's disease? Inflamm Bowel Dis. 2008; 14( suppl 2): S179S180.
  • 169
    Sandborn WJ, Feagan BG, Hanauer SB, et al. A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease. Gastroenterology. 2002; 122: 512530.
  • 170
    Domènech E, Mañosa M, Bernal I, et al. Impact of azathioprine on the prevention of postoperative Crohn's disease recurrence: results of a prospective, observational, long-term follow-up study. Inflamm Bowel Dis. 2008; 14: 508513.
  • 171
    Rispo A, Bucci L, Pesce G, et al. Bowel sonography for the diagnosis and grading of postsurgical recurrence of Crohn's disease. Inflamm Bowel Dis. 2006; 12: 486490.
  • 172
    Andreoli A, Cerro P, Falasco G, et al. Role of ultrasonography in the diagnosis of postsurgical recurrence of Crohn's disease. Am J Gastroenterol. 1998; 93: 11171121.
    Direct Link:
  • 173
    Parente F, Sampietro GM, Molteni M, et al. Behaviour of the bowel wall during the first year after surgery is a strong predictor of symptomatic recurrence of Crohn's disease: a prospective study. Aliment Pharmacol Ther. 2004; 20: 959968.
  • 174
    Maconi G, Sampietro GM, Cristaldi M, et al. Preoperative characteristics and postoperative behavior of bowel wall on risk of recurrence after conservative surgery in Crohn's disease: a prospective study. Ann Surg. 2001; 233: 345352.
  • 175
    Calabrese E, La Seta F, Buccellato A, et al. Crohn's disease: a comparative prospective study of transabdominal ultrasonography, small intestine contrast ultrasonography, and small bowel enema. Inflamm Bowel Dis. 2005; 11: 139145.
  • 176
    Calabrese E, Petruzziello C, Onali S, et al. Severity of postoperative recurrence in Crohn's disease: correlation between endoscopic and sonographic findings. Inflamm Bowel Dis. 2009; 15: 163516342.
  • 177
    Castiglione F, Bucci L, Pesce G, et al. Oral contrast-enhanced sonography for the diagnosis and grading of postsurgical recurrence of Crohn's disease. Inflamm Bowel Dis. 2008; 14: 12401245.
  • 178
    Nos P, Domenech E. Postoperative Crohn's disease recurrence: a practical approach. World J Gastroenterol. 2008; 14: 55405548.
  • 179
    Biancone L, Onali S, Calabrese E, et al. Non-invasive techniques for assessing postoperative recurrence in Crohn's disease. Dig Liver Dis. 2008; 40 Suppl 2: S265S270.
  • 180
    Biancone L, Calabrese E, Petruzziello C, et al. Wireless capsule endoscopy and small intestine contrast ultrasonography in recurrence of Crohn's disease. Inflamm Bowel Dis. 2007; 13: 12561265.
  • 181
    Pallotta N, Barberani F, Giovannone M. Ultrasound assessment of the degree of transmural lesions predicts the severity of endoscopic lesions of the ileo-colonic anastomosis after ‘curative’ ileal resection in Crohn's disease. Gastroenterology. 2009; 136.
  • 182
    Biancone L, Fiori R, Tosti C, et al. Virtual colonoscopy compared with conventional colonoscopy for stricturing postoperative recurrence in Crohn's disease. Inflamm Bowel Dis. 2003; 9: 343350.
  • 183
    Allen PB, De Cruz P, Lee WK, et al. Noninvasive imaging of the small bowel in Crohn's disease: the final frontier. Inflamm Bowel Dis. 2011 [Epub ahead of print].
  • 184
    Sailer J, Peloschek P, Reinisch W, et al. Anastomotic recurrence of Crohn's disease after ileocolic resection: comparison of MR enteroclysis with endoscopy. Eur Radiol. 2008; 18: 25122521.
  • 185
    Koilakou S, Sailer J, Peloschek P, et al. Endoscopy and MR enteroclysis: equivalent tools in predicting clinical recurrence in patients with Crohn's disease after ileocolic resection. Inflamm Bowel Dis. 2010; 16: 198203.
  • 186
    Sipponen T, Savilahti E, Kolho KL, et al. Crohn's disease activity assessed by fecal calprotectin and lactoferrin: correlation with Crohn's disease activity index and endoscopic findings. Inflamm Bowel Dis. 2008; 14: 4046.
  • 187
    Scarpa M, D'Inca R, Basso D, et al. Fecal lactoferrin and calprotectin after ileocolonic resection for Crohn's disease. Dis Colon Rectum. 2007; 50: 861869.
  • 188
    Orlando A, Modesto I, Castiglione F, et al. The role of calprotectin in predicting endoscopic post-surgical recurrence in asymptomatic Crohn's disease: a comparison with ultrasound. Eur Rev Med Pharmacol Sci. 2006; 10: 1722.
  • 189
    Lamb CA, Mohiuddin MK, Gicquel J, et al. Faecal calprotectin or lactoferrin can identify postoperative recurrence in Crohn's disease. Br J Surg. 2009; 96: 663674.
  • 190
    Florent C, L'Hirondel C, Desmazures C, et al. Intestinal clearance of alpha 1-antitrypsin. A sensitive method for the detection of protein-losing enteropathy. Gastroenterology. 1981; 81: 777780.
  • 191
    Florent C, L'Hirondel C, Desmazures C, et al. [Evaluation of ulcerative colitis and Crohn's disease activity by measurement of alpha-1-antitrypsin intestinal clearance (author's transl).] Gastroenterol Clin Biol. 1981; 5: 193197.
  • 192
    Meyers S, Wolke A, Field SP, et al. Fecal alpha 1-antitrypsin measurement: an indicator of Crohn's disease activity. Gastroenterology. 1985; 89: 1318.
  • 193
    Boirivant M, Pallone F, Ciaco A, et al. Usefulness of fecal alpha 1-antitrypsin clearance and fecal concentration as early indicator of postoperative asymptomatic recurrence in Crohn's disease. Dig Dis Sci. 1991; 36: 347352.
  • 194
    Bourreille A, Jarry M, D'Halluin PN, et al. Wireless capsule endoscopy versus ileocolonoscopy for the diagnosis of postoperative recurrence of Crohn's disease: a prospective study. Gut. 2006; 55: 978983.
  • 195
    Pons Beltrán V, Nos P, Bastida G, et al. Evaluation of postsurgical recurrence in Crohn's disease: a new indication for capsule endoscopy? Gastrointest Endosc. 2007; 66: 533540.
  • 196
    Katz JA. Postoperative endoscopic surveillance in Crohn's disease: bottom up or top down? Gastrointest Endosc. 2007; 66: 541543.
  • 197
    Esaki M, Matsumoto T, Hizawa K, et al. Intraoperative enteroscopy detects more lesions but is not predictive of postoperative recurrence in Crohn's disease. Surg Endosc. 2001; 15: 455459.
  • 198
    Lescut D, Vanco D, Bonniere P, et al. Perioperative endoscopy of the whole small bowel in Crohn's disease. Gut. 1993; 34: 647649.
  • 199
    Klein O, Colombel JF, Lescut D, et al. Remaining small bowel endoscopic lesions at surgery have no influence on early anastomotic recurrences in Crohn's disease. Am J Gastroenterol. 1995; 90: 19491952.
  • 200
    Biancone L, Scopinaro F, Ierardi M, et al. 99mTc-HMPAO granulocyte scintigraphy in the early detection of postoperative asymptomatic recurrence in Crohn's disease. Dig Dis Sci. 1997; 42: 15491556.
  • 201
    De Cruz P, Bernardi M, Allen PB, et al. Post-operative Crohn's disease recurrence: impact of endoscopic monitoring and treatment step-up on outcome. Gastroenterology. 2011 (in press).
  • 202
    Malireddy K, Larson DW, Sandborn WJ, et al. Recurrence and impact of postoperative prophylaxis in laparoscopically treated primary ileocolic Crohn disease. Arch Surg. 2010; 145: 4247.
  • 203
    Baudry C, Pacault M, Simon J, et al. Prevention of postoperative clinical recurrence in Crohn's disease (CD) based on colonoscopy within the first year after surgery for decision of a tailored treatment. J Crohn's Colitis. 2009; 3: S51.
  • 204
    Bordeianou L, Stein SL, Ho VP, et al. Immediate versus tailored prophylaxis to prevent symptomatic recurrences after surgery for ileocecal Crohn's disease? Surgery. 2011; 149: 7278.
  • 205
    Cunningham MF, Docherty NG, Coffey JC, et al. Postsurgical recurrence of ileal Crohn's disease: an update on risk factors and intervention points to a central role for impaired host-microflora homeostasis. World J Surg. 2010; 34: 16151626.
  • 206
    Kennedy ED, To T, Steinhart AH, et al. Do patients consider postoperative maintenance therapy for Crohn's disease worthwhile? Inflamm Bowel Dis. 2008; 14: 224235.
  • 207
    Brignola C, Cottone M, Pera A, et al. Mesalamine in the prevention of endoscopic recurrence after intestinal resection for Crohn's disease. Italian Cooperative Study Group. Gastroenterology. 1995; 108: 345349.
  • 208
    McLeod RS, Wolff BG, Steinhart AH, et al. Prophylactic mesalamine treatment decreases postoperative recurrence of Crohn's disease. Gastroenterology. 1995; 109: 404413.
  • 209
    Lochs H, Mayer M, Fleig WE, et al. Prophylaxis of postoperative relapse in Crohn's disease with mesalamine: European Cooperative Crohn's Disease Study VI. Gastroenterology. 2000; 118: 264273.
  • 210
    Caprilli R, Cottone M, Tonelli F, et al. Two mesalazine regimens in the prevention of the post-operative recurrence of Crohn's disease: a pragmatic, double-blind, randomized controlled trial. Aliment Pharmacol Ther. 2003; 17: 517523.
  • 211
    Ng SC, Kamm MA. Management of postoperative Crohn's disease. Am J Gastroenterol. 2008; 103: 10291035.
    Direct Link:
  • 212
    Camma C, Giunta M, Rosselli M, et al. Mesalamine in the maintenance treatment of Crohn's disease: a meta-analysis adjusted for confounding variables. Gastroenterology. 1997; 113: 14651473.
  • 213
    Ford AC, Achkar JP, Khan KJ, et al. Efficacy of 5-aminosalicylates in ulcerative colitis: systematic review and meta-analysis. Am J Gastroenterol. 106: 601616.
  • 214
    Doherty GA, GB, SP. Meta-analysis of mesalamine in the prevention of postoperative recurrence of Crohn's disease. Gastroenterology. 2009; 136.
  • 215
    Reinisch W, Angelberger S, Petritsch W, et al. Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn's disease with endoscopic recurrence: efficacy and safety results of a randomised, double-blind, double-dummy, multicentre trial. Gut. 2010; 59: 752759.
  • 216
    Doherty G, Bennett G, Patil S, et al. Interventions for prevention of post-operative recurrence of Crohn's disease. Cochrane Database System Rev. 2009: CD006873.
  • 217
    Rutgeerts P. Little benefit from mesalazine taken prophylactically after surgery for Crohn's disease. Gut. 2001; 48: 452453.
  • 218
    Lémann M. Review article: can post-operative recurrence in Crohn's disease be prevented? Aliment Pharmacol Ther. 2006; 24 Suppl 3: 2228.
  • 219
    Sutherland LR. Mesalamine for the prevention of postoperative recurrence: is nearly there the same as being there? Gastroenterology. 2000; 118: 436438.
  • 220
    Cottone M, Camma C. Mesalamine and relapse prevention in Crohn's disease. Gastroenterology. 2000; 119: 597.
  • 221
    Rutgeerts P, Hiele M, Geboes K, et al. Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection. Gastroenterology. 1995; 108: 16171621.
  • 222
    Rutgeerts P, Van Assche G, Vermeire S, et al. Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial. Gastroenterology. 2005; 128: 856861.
  • 223
    Doherty GA, Bennett GC, Cheifetz AS, et al. Meta-analysis: targeting the intestinal microbiota in prophylaxis for post-operative Crohn's disease. Aliment Pharmacol Ther. 2010; 31: 802809.
  • 224
    D'Haens GR, Vermeire S, Van Assche G, et al. Therapy of metronidazole with azathioprine to prevent postoperative recurrence of Crohn's disease: a controlled randomized trial. Gastroenterology. 2008; 135: 11231129.
  • 225
    Myrelid P, Svarm S, Andersson P, et al. Azathioprine as a postoperative prophylaxis reduces symptoms in aggressive Crohn's disease. Scand J Gastroenterol. 2006; 41: 11901195.
  • 226
    Abdelli MN, Ben Abdallah H, Houissa F, et al. [Azathioprine for prevention of postoperative recurrence in Crohn's disease.] Tunis Med. 2007; 85: 569572.
  • 227
    Pearson DC, May GR, Fick G, et al. Azathioprine for maintaining remission of Crohn's disease. Cochrane Database Syst Rev. 2000: CD000067.
  • 228
    D'Haens G, Geboes K, Ponette E, et al. Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn's disease. Gastroenterology. 1997; 112: 14751481.
  • 229
    Cuillerier E, Lémann M, Bouhnik Y, et al. Azathioprine for prevention of postoperative recurrence in Crohn's disease: a retrospective study. Eur J Gastrolenterol Hepatol. 2001; 13: 12911296.
  • 230
    Domenech E, Scala L, Bernal I, et al. [Azathioprine and mesalazine in the prevention of postsurgical recurrence of Crohn's disease: a retrospective study.] Gastroenterol Hepatol. 2004; 27: 563567.
  • 231
    Alves A, Panis Y, Joly F, et al. Could immunosuppressive drugs reduce recurrence rate after second resection for Crohn disease? Inflamm Bowel Dis. 2004; 10: 491495.
  • 232
    Hanauer SB, Korelitz BI, Rutgeerts P, et al. Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial. Gastroenterology. 2004; 127: 723729.
  • 233
    Nos P, Hinojosa J, Aguilera V, et al. [Azathioprine and 5-ASA in the prevention of postoperative recurrence of Crohn's disease.] Gastroenterol Hepatol. 2000; 23: 374378.
  • 234
    Peyrin-Biroulet L, Deltenre P, Ardizzone S, et al. Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn's disease: a meta-analysis. Am J Gastroenterol. 2009; 104: 20892096.
  • 235
    Papay P, Reinisch W, Ho E, et al. The impact of thiopurines on the risk of surgical recurrence in patients with Crohn's disease after first intestinal surgery. Am J Gastroenterol. 2010; 105: 11581164.
  • 236
    Sorrentino D, Terrosu G, Avellini C, et al. Infliximab with low-dose methotrexate for prevention of postsurgical recurrence of ileocolonic Crohn disease. Arch Internal Med. 2007; 167: 18041807.
  • 237
    Sorrentino D, Terrosu G, Avellini C, et al. Prevention of postoperative recurrence of Crohn's disease by infliximab. Eur J Gastrolenterol Hepatol. 2006; 18: 457459.
  • 238
    Okamoto K, Fujiya M, Nata T, et al. Infliximab may prevent post-operative recurrences in Crohn's disease. Gastroenterology. 2009; 136: A572.
  • 239
    Yamamoto T, Umegae S, Matsumoto K. Impact of infliximab therapy after early endoscopic recurrence following ileocolonic resection of Crohn's disease: a prospective pilot study. Inflamm Bowel Dis. 2009; 15: 14601466.
  • 240
    Regueiro M, Schraut WH, Baidoo L, et al. Two year postoperative follow-up of patients enrolled in the randomized controlled trial (RCT) of infliximab (IFX) for prevention of recurrent Crohn's disease (CD). Gastroenterology. 2009; 136: A522.
  • 241
    Regueiro M, Kip KE, Schraut WH, et al. 4.5 Yr follow-up of patients enrolled in the randomized controlled trial (RCT) of infliximab (Inf) for prevention of postoperative Crohn's disease (CD). Gastroenterology. 2010; 138: S694.
  • 242
    Sorrentino D, Paviotti A, Terrosu G, et al. Low-dose maintenance therapy with infliximab prevents postsurgical recurrence of Crohn's disease. Clin Gastroenterol Hepatol. 2010; 8: 591599e1; quiz e78–79.
  • 243
    Fernandez-Blanco I, Monturiol J, Martinez B. Adalimumab in the prevention of postoperative recurrence of Crohn's disease. Gastroenterology. 2010; 138.
  • 244
    Biancone L, Cretella M, Tosti C, et al. Local injection of infliximab in the postoperative recurrence of Crohn's disease. Gastrointest Endosc. 2006; 63: 486492.
  • 245
    Belluzzi A, Brignola C, Campieri M, et al. Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease. N Engl J Med. 1996; 334: 15571560.
  • 246
    Belluzzi A, Campieri M, Belloli C. A new enteric-coated preparation of Omega 3 fatty acids for preventing post-surgical recurrence in Crohn's disease. Gastroenterology. 1997; 112.
  • 247
    Turner D, Steinhart AH, Griffiths AM. Omega 3 fatty acids (fish oil) for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev. 2007: CD006443.
  • 248
    Turner D, Shah PS, Steinhart AH, et al. Maintenance of remission in inflammatory bowel disease using omega-3 fatty acids (fish oil): a systematic review and meta-analyses. Inflamm Bowel Dis. 2011; 17: 336345.
  • 249
    Dejaco C, Lichtenberger C, Miehsler W, et al. An open-label pilot study of granulocyte colony-stimulating factor for the treatment of severe endoscopic postoperative recurrence in Crohn's disease. Digestion. 2003; 68: 6370.
  • 250
    Yamamoto T, Nakahigashi M, Umegae S, et al. Impact of long-term enteral nutrition on clinical and endoscopic recurrence after resection for Crohn's disease: a prospective, non-randomized, parallel, controlled study. Aliment Pharmacol Ther. 2007; 25: 6772.
  • 251
    Ewe K, Böttger T, Buhr HJ, et al. Low-dose budesonide treatment for prevention of postoperative recurrence of Crohn's disease: a multicentre randomized placebo-controlled trial. German Budesonide Study Group. Eur J Gastrolenterol Hepatol. 1999; 11: 277282.
  • 252
    Hellers G, Cortot A, Jewell D, et al. Oral budesonide for prevention of postsurgical recurrence in Crohn's disease. The IOIBD Budesonide Study Group. Gastroenterology. 1999; 116: 294300.
  • 253
    Bruewer M, Utech M, Rijcken EJM, et al. Preoperative steroid administration: effect on morbidity among patients undergoing intestinal bowel resection for Crohn's disease. World J Surg. 2003; 27: 13061310.
  • 254
    Irving PM, Gearry RB, Sparrow MP, et al. Review article: appropriate use of corticosteroids in Crohn's disease. Aliment Pharmacol Ther. 2007; 26: 313329.
  • 255
    Marteau P, Lemann M, Seksik P, et al. Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn's disease: a randomised, double blind, placebo controlled GETAID trial. Gut. 2006; 55: 842847.
  • 256
    Van Gossum A, Dewit O, Louis E, et al. Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn's disease after ileo-caecal resection. Inflamm Bowel Dis. 2007; 13: 135142.
  • 257
    Prantera C, Scribano ML, Falasco G, et al. Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG. Gut. 2002; 51: 405409.
  • 258
    Chermesh I, Tamir A, Reshef R, et al. Failure of Synbiotic 2000 to prevent postoperative recurrence of Crohn's disease. Dig Dis Sci. 2007; 52: 385389.
  • 259
    Madsen K, Backer J, Leddin D, et al. A randomized controlled trial of VSL3 for the prevention of endoscopic recurrence following surgery for Crohn's disease. Gastroenterology. 2008; 134.
  • 260
    Colombel JF, Rutgeerts P, Malchow H, et al. Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease. Gut. 2001; 49: 4246.
  • 261
    Ananthakrishnan AN, Juillerat P, Hur C, et al. A decision analysis of competing strategies for prevention of post-operative recurrence in Crohn's disease. Gastroenterology. 2011.