Supported by grants from the DFG (SFB621, A.B., H.H.) and Studienstiftung des Deutschen Volkes (G.B.).
1536-4844/asset/IBD_left.gif?v=1&s=9aca2b5041534c51cac4bb66560294c77a457a07)
1536-4844/asset/IBD_right.gif?v=1&s=402e3e241083497ae622916e85e47f64138255a4)
Original Article
You have full text access to this OnlineOpen article
Strain-specific colitis susceptibility in IL10-deficient mice depends on complex gut microbiota–host interactions†
Article first published online: 11 JAN 2012
DOI: 10.1002/ibd.21895
Copyright © 2012 Crohn's & Colitis Foundation of America, Inc.
Additional Information
How to Cite
Büchler, G., Wos-Oxley, M. L., Smoczek, A., Zschemisch, N.-H., Neumann, D., Pieper, D. H., Hedrich, H. J. and Bleich, A. (2012), Strain-specific colitis susceptibility in IL10-deficient mice depends on complex gut microbiota–host interactions. Inflamm Bowel Dis, 18: 943–954. doi: 10.1002/ibd.21895
- †
Publication History
- Issue published online: 12 APR 2012
- Article first published online: 11 JAN 2012
- Manuscript Accepted: 17 AUG 2011
- Manuscript Received: 8 AUG 2011
REFERENCES
- 1. Inflammatory bowel disease. N Engl J Med. 2002; 347: 417–429.
- 2, . Environment as a critical factor for the pathogenesis and outcome of gastrointestinal disease: experimental and human inflammatory bowel disease and Helicobacter-induced gastritis. Pathobiology. 2005; 72: 293–307.
- 3, , , et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 1993; 75: 263–274.
- 4, , , et al. A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice. Proc Natl Acad Sci U S A. 2001; 98: 13820–13825.
- 5, , , et al. Genetics of colitis susceptibility in IL-10-deficient mice: backcross versus F2 results contrasted by principal component analysis. Genomics. 2002; 80: 274–282.
- 6, , , et al. Refined histopathologic scoring system improves power to detect colitis QTL in mice. Mamm Genome. 2004; 15: 865–871.
- 7, , , et al. A major quantitative trait locus on mouse chromosome 3 is involved in disease susceptibility in different colitis models. Gastroenterology. 2005; 128: 74–85.
- 8, , , et al. Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus. Proc Natl Acad Sci U S A. 2011; 108: 7137–7141.
- 9, , , et al. Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens. Gastroenterology. 2005; 129: 1473–1484.
- 10, , , et al. Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity. Inflamm Bowel Dis. 2010; 16: 765–775.
- 11, , , et al. Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses. Physiol Genomics. 2006; 25: 426–434.
- 12, . Genetic and environmental context determines the course of colitis developing in IL-10-deficient mice. Inflamm Bowel Dis. 2002; 8: 347–355.
- 13, , , et al. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2001; 281: G764–778.
- 14, , , et al. Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism. Infect Immun. 1998; 66: 5157–5166.
- 15, , , et al. Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units. Lab Anim. 2002; 36: 20–42.
- 16, . Natural and experimental Helicobacter infections. Comp Med. 2004; 54: 128–158.
- 17. Untersuchungen zur Pathogenität von Helicobacter hepaticus: genomische und funktionelle Aspekte. Institut für Hygiene und Mikrobiologie. Würzburg, Germany: Bayerische Julius-Maximilian-Universität; 2006.
- 18, , , et al. The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus. Proc Natl Acad Sci U S A. 2003; 100: 7901–7906.
- 19, , , et al. Identification of murine helicobacters by PCR and restriction enzyme analyses. J Clin Microbiol. 1996; 34: 942–946.
- 20, , , et al. Identification of widespread Helicobacter hepaticus infection in feces in commercial mouse colonies by culture and PCR assay. J Clin Microbiol. 1995; 33: 2968–2972.
- 21, , , et al. Comparison of four diagnostic methods for detection of Helicobacter species in laboratory mice. Lab Anim Sci. 1998; 48: 85–91.
- 22, , , et al. CpG motifs of bacterial DNA exert protective effects in mouse models of IBD by antigen-independent tolerance induction. Gastroenterology. 2009; 136: 278–287.
- 23, , , et al. Injection of IL-12- and IL-18-encoding plasmids ameliorates the autoimmune pathology of MRL/Mp-Tnfrsf6lpr mice: synergistic effect on autoimmune symptoms. Int Immunol. 2006; 18: 1779–1787.
- 24, , , et al. Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease. Genes Immun. 2010; 11: 219–231.
- 25, , , et al. Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice. Gastroenterology. 1999; 116: 1107–1114.
- 26, , , et al. Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology. 2001; 121: 580–591.
- 27, , , et al. Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice. Inflamm Bowel Dis. 2002; 8: 71–80.
- 28, , , et al. Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance. Gut. 2003; 52: 975–980.
- 29, . Enterococcus faecalis induces inflammatory bowel disease in interleukin-10 knockout mice. Am J Pathol. 2002; 160: 2253–2257.
- 30, , , et al. Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice. Infect Immun. 2000; 68: 5107–5113.
- 31, , , et al. Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice. Gastroenterology. 1994; 107: 1726–1735.
- 32, , , et al. Inhibitory effect of enterohepatic Helicobacter hepaticus on innate immune responses of mouse intestinal epithelial cells. Infect Immun. 2007; 75: 2717–2728.
- 33, , , et al. Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. J Exp Med. 2009; 206: 525–534.
- 34, , , et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut. 2003; 52: 65–70.
- 35, , , et al. IL-23/IL-17 axis in IBD. Inflamm Bowel Dis. 2010; 16: 1808–1813.
- 36, , , et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest. 2006; 116: 1310–1316.
- 37, , , et al. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med. 2006; 203: 2485–2494.
- 38, , , et al. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A. 2007; 104: 13780–13785.
- 39, , , et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010; 464: 59–65.
- 40, , , et al. Dynamics of the mucosa-associated flora in ulcerative colitis patients during remission and clinical relapse. J Clin Microbiol. 2008; 46: 3510–3513.
- 41, , , et al. Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe. 2007; 2: 119–129.
- 42, , , et al. Colonization of the cecal mucosa by Helicobacter hepaticus impacts the diversity of the indigenous microbiota. Infect Immun. 2005; 73: 6952–6961.
- 43, , , et al. Colonization dynamics of altered Schaedler flora is influenced by gender, aging, and Helicobacter hepaticus infection in the intestines of Swiss Webster mice. Appl Environ Microbiol. 2006; 72: 5100–5103.
- 44, , , et al. Visualization of Helicobacter species within the murine cecal mucosa using specific fluorescence in situ hybridization. Helicobacter. 2005; 10: 114–124.
- 45, , , et al. Spatial distribution and stability of the eight microbial species of the altered Schaedler flora in the mouse gastrointestinal tract. Appl Environ Microbiol. 2004; 70: 2791–2800.
- 46, , , et al. Probiotic Lactobacillus spp. diminish Helicobacter hepaticus-induced inflammatory bowel disease in interleukin-10-deficient mice. Infect Immun. 2005; 73: 912–920.
- 47, , , et al. Family relationship of female breeders reduce the systematic inter-individual variation in the gut microbiota of inbred laboratory mice. Lab Anim. 2010; 44: 283–289.
- 48, , . Differential induction of colitis and gastritis in HLA-B27 transgenic rats selectively colonized with Bacteroides vulgatus or Escherichia coli. Infect Immun. 1999; 67: 2969–2974.
- 49, , , et al. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest. 1996; 98: 945–953.
- 50, , , et al. Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell Host Microbe. 2010; 9: 390–403.