The first two authors contributed equally to this work.
Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway†
Article first published online: 21 OCT 2011
Copyright © 2011 Crohn's & Colitis Foundation of America, Inc.
Inflammatory Bowel Diseases
Volume 18, Issue 5, pages 889–899, May 2012
How to Cite
Nimmo, E. R., Prendergast, J. G., Aldhous, M. C., Kennedy, N. A., Henderson, P., Drummond, H. E., Ramsahoye, B. H., Wilson, D. C., Semple, C. A. and Satsangi, J. (2012), Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway. Inflamm Bowel Dis, 18: 889–899. doi: 10.1002/ibd.21912
P.H. and the pediatric IBD work were supported by a Medical Research Council grant for the PICTS patient cohort (project grant number G0800675). N.A.K. is supported by grants from the Chief Scientist Office (ETM/75) and the charity Cure Crohn's Colitis.
- Issue published online: 12 APR 2012
- Article first published online: 21 OCT 2011
- Manuscript Accepted: 8 SEP 2011
- Manuscript Received: 2 SEP 2011
Additional Supporting Information may be found in the online version of this article.
|IBD_21912_sm_SuppFig1.tif||2097K||Supplementary Figure 1.|
|IBD_21912_sm_SuppTab1.doc||68K||Supporting Table 1: Phenotypes, genotypes and clinical details of adult patients and controls in study.|
|IBD_21912_sm_SuppTab2.doc||34K||Supporting Table 2: Phenotypes of early onset patients.|
|IBD_21912_sm_SuppTab3.doc||4173K||Supporting table 3: Differential methylation of CpG sites on genes.|
|IBD_21912_sm_SuppTab4.doc||25K||Supporting Table 4: Fold enrichments (and corresponding p values) for SNPs within 25kb, 100kb and 50kb (split into all, hyper methylated and hypo methylated SNPs) of known CD loci. Fold enrichment are the proportion of sites below various differential methylation FDR corrected significance cut offs over the proportion of all sites, table corresponds to data presented in Figure 1A and B.|
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