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Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab is associated with a profound long-lasting depletion of Foxp3+ regulatory T cells: A mechanistic explanation for ipilimumab-induced severe enterocolitis?

Authors

  • S. Nancey MD, PhD,

    1. INSERM U 851 “Immunité et Vaccination” CERVI, IFR 128 Biosciences Lyon-Gerland Lyon, France
    2. Hospices Civils de Lyon Service de Gastroentérologie Centre Hospitalier Lyon-Sud Pierre-Bénite, France
    3. University Claude Bernard Lyon 1 Lyon, France
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  • G. Boschetti MD,

    1. INSERM U 851 “Immunité et Vaccination” CERVI, IFR 128 Biosciences Lyon-Gerland Lyon, France
    2. Hospices Civils de Lyon Service de Gastroentérologie Centre Hospitalier Lyon-Sud Pierre-Bénite, France
    3. University Claude Bernard Lyon 1 Lyon, France
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  • E. Cotte MD, PhD,

    1. University Claude Bernard Lyon 1 Lyon, France
    2. Hospices Civils de Lyon Service de Chirurgie générale Centre Hospitalier Lyon-Sud Pierre-Bénite, France
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  • K. Ruel MSc,

    1. INSERM U 851 “Immunité et Vaccination” CERVI, IFR 128 Biosciences Lyon-Gerland Lyon, France
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  • T. Almeras MSc,

    1. INSERM U 851 “Immunité et Vaccination” CERVI, IFR 128 Biosciences Lyon-Gerland Lyon, France
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  • M. Chauvenet MD,

    1. Hospices Civils de Lyon Service de Gastroentérologie Centre Hospitalier Lyon-Sud Pierre-Bénite, France
    2. University Claude Bernard Lyon 1 Lyon, France
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  • K. Stroeymeyt MD,

    1. Hospices Civils de Lyon Service de Gastroentérologie Centre Hospitalier Lyon-Sud Pierre-Bénite, France
    2. University Claude Bernard Lyon 1 Lyon, France
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  • D. Moussata MD, PhD,

    1. Hospices Civils de Lyon Service de Gastroentérologie Centre Hospitalier Lyon-Sud Pierre-Bénite, France
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  • D. Kaiserlian PhD,

    1. INSERM U 851 “Immunité et Vaccination” CERVI, IFR 128 Biosciences Lyon-Gerland Lyon, France
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  • B. Flourié MD, PhD

    1. INSERM U 851 “Immunité et Vaccination” CERVI, IFR 128 Biosciences Lyon-Gerland Lyon, France
    2. Hospices Civils de Lyon Service de Gastroentérologie Centre Hospitalier Lyon-Sud Pierre-Bénite, France
    3. University Claude Bernard Lyon 1 Lyon, France
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  • We thank SFR Biosciences Gerland-Lyon Sud (UMS344/US8) for the contribution of the platform of cytometry.

No abstract is available for this article.

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