Performance of interferon-gamma release assays in patients with inflammatory bowel disease: A systematic review and meta-analysis
Article first published online: 31 JAN 2012
Copyright © 2012 Crohn's & Colitis Foundation of America, Inc.
Inflammatory Bowel Diseases
Volume 18, Issue 11, pages 2034–2042, November 2012
How to Cite
Shahidi, N., Fu, Y.-T. N., Qian, H. and Bressler, B. (2012), Performance of interferon-gamma release assays in patients with inflammatory bowel disease: A systematic review and meta-analysis. Inflamm Bowel Dis, 18: 2034–2042. doi: 10.1002/ibd.22901
- Issue published online: 15 OCT 2012
- Article first published online: 31 JAN 2012
- Manuscript Received: 9 JAN 2012
- Manuscript Accepted: 9 JAN 2012
- inflammatory bowel disease;
- interferon-gamma release assay;
- tuberculin skin test;
- immunosuppressive therapy
Guidelines mandate screening for latent tuberculosis infection (LTBI) prior to anti-tumor necrosis factor (anti-TNF) therapy in patients with inflammatory bowel disease (IBD). However, many are already on immunosuppressive therapy (IST) that may affect the precision of the Tuberculin skin test (TST). Our aim was to assess the performance of the new interferon-gamma release assays (IGRAs) to detect LTBI in patients with IBD.
MEDLINE and EMBASE were searched (up to June 2011) to identify studies evaluating the performance of IGRAs (QuantiFERON-TB Gold [QFT-2G], QuantiFERON-TB Gold In-Tube [QFT-3G] and T-SPOT.TB) in individuals with IBD. Forest plots and pooled estimates using random effects models were created where applicable.
Nine unique studies encompassing 1309 patients with IBD were included for analysis. The pooled concordance between the TST and QFT-2G/QFT-3G was 85% (95% confidence interval [CI] 77%–90%). The concordance of the TST and TSPOT.TB was 72% (95% CI 64%–78%). Studies assessing agreement reported more IGRA−/TST+ results versus IGRA+/TST− results. The pooled percentage of indeterminate results was 5% (95% CI 2%–9%) for QFT-2G/QFT-3G. TSPOT.TB showed similar results. Both positive QFT-2G/QFT-3G results (pooled odds ratio [OR] 0.37, 95% CI 0.16–0.87) and positive TST results (pooled OR 0.28, 95% CI 0.10–0.80) were significantly influenced by IST (both P = 0.02).
While it remains difficult to determine superiority between the IGRAs and the TST, both are negatively affected by IST. Therefore, screening prior to initiation of IST should be considered. Nevertheless, it is imperative that all patients receive screening prior to anti-TNF therapy. (Inflamm Bowel Dis 2012;)