Crohn's and Colitis UK and CORE/British Society of Paediatric Gastroenterology Hepatology and Nutrition (BSPGHAN) funded J.R.G.'s research.
Mood disorders in inflammatory bowel disease: Relation to diagnosis, disease activity, perceived stress, and other factors†
Article first published online: 22 FEB 2012
Copyright © 2012 Crohn's & Colitis Foundation of America, Inc.
Inflammatory Bowel Diseases
Volume 18, Issue 12, pages 2301–2309, December 2012
How to Cite
Goodhand, J.R., Wahed, M., Mawdsley, J.E., Farmer, A.D., Aziz, Q. and Rampton, D.S. (2012), Mood disorders in inflammatory bowel disease: Relation to diagnosis, disease activity, perceived stress, and other factors. Inflamm Bowel Dis, 18: 2301–2309. doi: 10.1002/ibd.22916
- Issue published online: 15 NOV 2012
- Article first published online: 22 FEB 2012
- Manuscript Accepted: 23 JAN 2012
- Manuscript Received: 10 JAN 2012
- ulcerative colitis;
- Crohn's disease;
- psychological stress;
Anxiety and depression are common in patients with inflammatory bowel disease (IBD); however, the factors associated with mood disorders in patients with ulcerative colitis (UC) and Crohn's disease (CD) are poorly defined.
In all, 103 patients with UC, 101 with CD, and 124 healthy controls completed the Hospital Anxiety and Depression Scale (HADS). Disease activity was defined both from symptom scores and in UC endoscopically, and in CD by fecal calprotectin and/or serum C-reactive protein. Multivariate regression analyses were used to identify factors associated with anxiety and depression.
In both UC and CD, anxiety (HADS-A) and depression (HADS-D) scores were higher than in controls (HADS-A: 8.5 ± 4.1 [mean ± SD], 8.6 ± 3.9, 3.2 ± 1.8, P < 0.001; and HADS-D: 4.1 ± 3.3, 4.7 ± 3.3, 1.7 ± 1.4, P < 0.001, respectively). There were no differences in the prevalence of mild, moderate, and severe anxiety and depression in UC and CD. In UC, anxiety scores were associated with perceived stress and a new diagnosis of IBD; depression was associated with stress, inpatient status, and active disease. In CD, anxiety was associated with perceived stress, abdominal pain, and lower socioeconomic status, and depression with perceived stress and increasing age.
Anxiety and depression are common in IBD. Perceived stress is associated with mood disturbances in both UC and CD, but the other associated factors differ in the two diseases. Gastroenterologists should look for mood disorders in IBD and consider stress management and psychotherapy in affected patients. (Inflamm Bowel Dis 2012;)