Original Article

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Defective tumor necrosis factor release from Crohn's disease macrophages in response to toll-like receptor activation: Relationship to phenotype and genome-wide association susceptibility loci†

  1. Gavin W. Sewell PhD1,‡,
  2. Farooq Z. Rahman PhD1,2,‡,
  3. Adam P. Levine BSc1,
  4. Luke Jostins MPhil3,
  5. Philip J. Smith MRCP1,
  6. Ann P. Walker PhD1,
  7. Stuart L. Bloom FRCP2,
  8. Anthony W. Segal PhD, FRS1,
  9. Andrew M. Smith PhD1,*

Article first published online: 20 MAR 2012

DOI: 10.1002/ibd.22952

Issue

Inflammatory Bowel Diseases

Inflammatory Bowel Diseases

Volume 18, Issue 11, pages 2120–2127, November 2012

Additional Information

How to Cite

Sewell, G. W., Rahman, F. Z., Levine, A. P., Jostins, L., Smith, P. J., Walker, A. P., Bloom, S. L., Segal, A. W. and Smith, A. M. (2012), Defective tumor necrosis factor release from Crohn's disease macrophages in response to toll-like receptor activation: Relationship to phenotype and genome-wide association susceptibility loci. Inflamm Bowel Dis, 18: 2120–2127. doi: 10.1002/ibd.22952

Author Information

  1. 1

    Division of Medicine, University College London, London, UK

  2. 2

    Department of Gastroenterology, UCLH NHS Foundation Trust, London, UK

  3. 3

    Statistical and Computational Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK

  1. ‡

    The first two authors contributed equally to this work.

*Department of Medicine, Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK

  1. †

    Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms

  2. ‡

    The first two authors contributed equally to this work.

Publication History

  1. Issue published online: 15 OCT 2012
  2. Article first published online: 20 MAR 2012
  3. Manuscript Accepted: 17 FEB 2012
  4. Manuscript Received: 10 FEB 2012

Funded by

  • Wellcome Trust. Grant Number: (grant GHACB)
  • National Association of Colitis and Crohn's disease

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