The first two authors contributed equally to this work.
Does smoking influence Crohn's disease in the biologic era? The tabacrohn study
Article first published online: 29 MAR 2012
Copyright © 2012 Crohn's & Colitis Foundation of America, Inc.
Inflammatory Bowel Diseases
How to Cite
Nunes, T., Etchevers, M. J., Merino, O., Gallego, S., García-Sánchez, V., Marín-Jiménez, I., Menchén, L., Barreiro-de Acosta, M., Bastida, G., García, S., Gento, E., Ginard, D., Gomollón, F., Arroyo, M., Monfort, D., García-Planella, E., Gonzalez, B., Loras, C., Agustí, C., Figueroa, C., Sans, M. and for the TABACROHN Study Group of GETECCU, Spanish Working Group in Crohn's Disease and Ulcerative Colitis (2012), Does smoking influence Crohn's disease in the biologic era? The tabacrohn study. Inflamm Bowel Dis. doi: 10.1002/ibd.22959
- Article first published online: 29 MAR 2012
- Manuscript Accepted: 28 FEB 2012
- Manuscript Received: 24 FEB 2012
- inflammatory bowel disease;
- Crohn's disease;
- environmental factors;
- disease phenotype
While most studies have found a negative effect of smoking on Crohn's disease (CD) phenotype, more recent data have failed to reproduce this association, which might be due to a current wider use of thiopurines and biologic therapy. The TABACROHN study aimed at defining the impact of smoking on CD in the largest published series.
This multicenter cross-sectional study included 1170 CD patients. Patients were classified as nonsmokers, current smokers, or former smokers according to their present smoking status. Clinical data regarding disease characteristics, treatment, and complications were collected.
Smokers were more frequently under maintenance treatment when compared to nonsmokers. In addition, current smokers presented higher use of biologic drugs compared to nonsmokers. Tobacco exposure and a higher tobacco load were independent predictors of need for maintenance treatment and stenosing phenotype, respectively.
In the era of early and widespread use of immunosuppressants and biologics, tobacco exposure is an independent predictor of need for maintenance treatment, specifically biologic therapy. The wider use of biologics and immunosuppressants could account for the existence of no major differences in disease behavior and complications between nonsmokers and current smokers. (Inflamm Bowel Dis 2012;)