• 1
    Satsangi J, Rosenberg WMC, Jewell DP. The prevalence of inflammatory bowel disease in relatives of patients with Crohn's disease. Eur J Gastro Hepatol 1994; 6: 4136.
  • 2
    Tysk C, Lindberg E, Järnerot G, Flodérus-Myrhed B. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins: a study of heritability and the influence of smoking. Gut 1988; 29: 9906.
  • 3
    Satsangi J, Jewell DP, Rosenberg WMC. Bell JI. Genetics of inflammatory bowel disease. Gut 1994; 35: 696700.
  • 4
    Satsangi J, Parkes M, Louis E, et al, Two-stage genome-wide search in inflammatory bowel disease: evidence for susceptibility loci on chromosomes 3, 7 and 12. Nature Genetics 1996; 14: 199202.
  • 5
    Satsangi J, Jewell DP, Bell JI. Leading article: the genetics of inflammatory bowel disease. Gut 1997; 40: 5723.
  • 6
    Futami S, Aoyama N, Honsako Y, et al, HLA-DRB1*1502 allele, subtype of DR15, is associated with susceptibility to ulcerative colitis and its progression. Dig Dis Sci 1995; 40: 8148.
  • 7
    Toyoda H, Wang S-J, Yang H, et al, Distinct association of HLA class II genes with inflammatory bowel disease. Gastroenterology 1993; 104: 7418.
  • 8
    Satsangi J, Welsh KI, Bunce M, et al, Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease. Lancet 1996; 347: 12127.
  • 9
    Roussomoustakaki M, Satsangi J, Welsh KI, et al, Genetic markers may predict disease behaviour in patients with ulcerative colitis. Gastroenterology 1997; 112: 184553.
  • 10
    Duerr RH, Targan SR, Landers CJ, Sutherland LR, Shanahan F. Anti-neutrophil cytoplasmic antibodies in ulcerative colitis: comparison with other colitides/diarrhoeal illnesses. Gastroenterology 1992; 100: 15906.
  • 11
    Shanahan F, Duerr R, Rotter JI, Yang H, Sutherland LR, et al, Neutrophil auto-antibodies in ulcerative colitis: familial aggregation and genetic heterogeneity. Gastroenterology 1992; 103: 45661.
  • 12
    Yang H, Rotter JI, Toyoda H, et al, Ulcerative colitis: a genetically heterogeneous disorder defined by genetic (HLA class II) and sub-clinical (antineutrophil cytoplasmic antibodies) markers. J Clin Invest 1993; 92: 10804.
  • 13
    Seibold F, Slametschka D, Gregor M, Weber P. Neutrophil auto-antibodies: a genetic marker in primary sclerosing cholangitis and ulcerative colitis. Gastroenterology 1994; 107: 5326.
  • 14
    Lee JC, Lennard-Jones JE, Cambridge G. Antineutrophil antibodies in familial inflammatory bowel disease. Gastroenterology 1995; 108: 42833.
  • 15
    Bansi D, Lo SK, Chapman RWG, Fleming KA. Absence of antineutrophil cytoplasmic antibodies in relatives of UK patients with primary sclerosing cholangitis and ulcerative colitis. Eur J Gastro Hepatol 1996; 8: 1117.
  • 16
    Duerr RH, Neigut DA. Molecularly defined HLA-DR2 alleles in ulcerative colitis and an anti-neutrophil cytoplasmic antibody-positive subgroup. Gastroenterology 1995; 108: 4237.
  • 17
    Vasiliauskas EA, Plevy SE, Landers CJ, et al, Peri-nuclear antineutrophil cytoplasmic antibodies in patients with Crohn's disease define a clinical subgroup. Gastroenterology 1996; 110: 18109.
  • 18
    Jamar-Leclero N, Reumaux D, Duthilleul P. Colombel JF. Do p-ANCA define a clinical sub-group in patients with Crohn's disease? Gastroenterology 1997; 112: 3167.
  • 19
    Miller S, Dykes D, Polesky H. A salting-out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215.
  • 20
    Bunce M, Taylor CJ, Welsh KI. Rapid HLA-DBQ typing by eight PCR amplifications with sequence-specific primers (PCR-SSP). Hum Immunol 1993; 37: 2016.
  • 21
    Olerup O, Zetterquist H. HLA-DR typing by PCR amplifications with sequence-specific primers in 2 hours: an alternative to serological DR typing in clinical practice including donor–recipient matching in cadaveric transplantation. Tissue Antigens 1992; 39: 22535.
  • 22
    Wilson AG, de Vries N, Pociot F, di Giovine FS, van der Putte LBA, Duff GW. An allelic polymorphism within the human tumour necrosis factor-alpha promoter region is strongly associated with HLA A1, B8 and DR3 alleles. J Exp Med 1993; 177: 55760.
  • 23
    Verjans GMGM, Brinkman BMN, van Doornik CEM, Kijlstra A, Verweij CL. Polymorphism of tumour necrosis factor-a (TNF-a) at position −308 in relation to ankylosing spondylitis. Clin Exp Immunol 1994; 97: 457.
  • 24
    Saxon A, Shanahan F, Landers C, Ganz T, Targan S. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol 1990; 86: 20210.
  • 25
    Wallington TB, Gooi HC, Non-organ specific antibodies. In: GooiHC, ChapelH, ed. Clinical immunology: a practical approach. Oxford: IRL Press, Oxford University Press, 1990: 195220.
  • 26
    Louis E, Satsangi J, Roussmoustakaki M, et al, Cytokine gene polymorphisms in inflammatory bowel disease. Gut 1996; 39: 70510.
  • 27
    Chapman RW. Aetiology and natural history of primary sclerosing cholangitis: a decade of progress? Gut 1991; 32: 14335.
  • 28
    Mulder AHL, Broekroelofs J, Horst G, Limburg PC, Nelis GF, Kallenberg CGM. Anti-neutrophil cytoplasmic antibodies (ANCA) in inflammatory bowel disease: characterisation and clinical correlates. Clin Exp Immunol 1994; 95: 4907.
  • 29
    Aitola P, Miettinen A, Mattila A, Matikainen M, Soppi E. Effect of proctocolectomy on serum antineutrophil cytoplasmic antibodies in patients with chronic ulcerative colitis. J Clin Pathol 1995; 48: 6457.
  • 30
    Lindgren S, Floren CH, Lindhagen T, Starck M, Stewenius J, Nassberger L. Low prevalence of anti-neutrophil cytoplasmic antibodies in ulcerative colitis patients with long-term remission. Eur J Gastro Hepatol 1995; 7: 5638.
  • 31
    Satsangi J, Jewell DP. Leading article: are cytokine gene polymorphisms important in the pathogenesis of inflammatory bowel disease? Eur J Gastro Hepatol 1996; 8: 979.
  • 32
    Schumacher G, Kollberg B, Sandstedt B, Ljungh A, Nassberger L. Circulating granulocyte antibodies in first attacks of colitis. Scand J Gastroenterol 1995; 30: 15763.
  • 33
    Hertervig E, Wieslander J, Johansson C, Wiik A, Nilsson A. Antineutrophil cytoplasmic antibodies in chronic inflammatory bowel disease. Scand J Gastroenterol 1995; 30: 6938.
  • 34
    Targan SR, Landers CJ, Cobb L, MacDermott RP, Vidrich A. Perinuclear anti-neutrophil cytoplasmic antibodies are spontaneously produced by mucosal B cells of ulcerative colitis patients. J Immunol 1995; 155: 32627.
  • 35
    Dignass A, Goebell H. Genetics of inflammatory bowel disease. Curr Opin Gastroenterol 1995; 11: 2927.
  • 36
    Billing P, Tahir S, Calfin B, et al, Nuclear localisation of the antigen detected by ulcerative colitis-associated perinuclear anti-neutrophil cytoplasmic antibodies. Am J Pathol 1995; 147: 97987.
  • 37
    Eggena MP, Targan SR, Vidrich A, Clemons DF, Iwancyzk L, Braun J. Histone H1: the UC-specific pANCA target antigen. FASEB J 1996; 10: 463.
  • 38
    Sobajima J, Ozaki S, Osakada K, et al, Novel autoantigens of perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) in ulcerative colitis: non-histone chromosomal proteins (HMG1 and HMG2). Clin Exp Immunol 1997; 107: 13541.