Special Series

The tissue residue approach for toxicity assessment: Findings and critical reviews from a Society of Environmental Toxicology and Chemistry Pellston Workshop

  1. James P Meador1,*,
  2. William J Adams2,
  3. Beate I Escher3,
  4. Lynn S McCarty4,
  5. Anne E McElroy5,
  6. Keith G Sappington6

Article first published online: 23 DEC 2010

DOI: 10.1002/ieam.133

Issue

Integrated Environmental Assessment and Management

Integrated Environmental Assessment and Management

Special Issue: Tissue Residue Approach Special Series

Volume 7, Issue 1, pages 2–6, January 2011

Additional Information

How to Cite

Meador, J. P., Adams, W. J., Escher, B. I., McCarty, L. S., McElroy, A. E. and Sappington, K. G. (2011), The tissue residue approach for toxicity assessment: Findings and critical reviews from a Society of Environmental Toxicology and Chemistry Pellston Workshop. Integr Environ Assess Manag, 7: 2–6. doi: 10.1002/ieam.133

Author Information

  1. 1

    Ecotoxicology and Environmental Fish Health Program, Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration Fisheries, 2725 Montlake Boulevard East, Seattle, Washington 98112, USA

  2. 2

    Rio Tinto, Lake Point, Utah, USA

  3. 3

    National Research Centre for Environmental Toxicology, The University of Queensland, Australia

  4. 4

    LS McCarty Scientific Research & Consulting, Ontario, Canada

  5. 5

    School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, New York, USA

  6. 6

    Office of Pesticide Programs, US Environmental Protection Agency, Washington, District of Columbia

*Ecotoxicology and Environmental Fish Health Program, Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration Fisheries, 2725 Montlake Boulevard East, Seattle, Washington 98112, USA.

Publication History

  1. Issue published online: 23 DEC 2010
  2. Article first published online: 23 DEC 2010
  3. Manuscript Accepted: 4 AUG 2010
  4. Manuscript Revised: 1 JUL 2010
  5. Manuscript Received: 20 MAY 2010
Corrected by:

Erratum: Erratum: The tissue residue approach for toxicity assessment: Findings and critical reviews from a Society of Environmental Toxicology and Chemistry Pellston Workshop

Vol. 7, Issue 2, 310, Article first published online: 31 JAN 2011

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Keywords:

  • Tissue residue toxicity;
  • Pellston workshop;
  • Critical review

Abstract

Over the past few years, the “critical body residue” approach for assessing toxicity based on bioaccumulated chemicals has evolved into a more expansive consideration of tissue residues as the dose metric when defining dose–response relationships, evaluating mixtures, developing protective guidelines, and conducting risk assessments. Hence, scientists refer to “tissue residue approach for toxicity assessment” or “tissue residue-effects approach” (TRA) when addressing ecotoxicology issues pertaining to tissue (or internal) concentrations. This introduction provides an overview of a SETAC Pellston Workshop held in 2007 to review the state of the science for using tissue residues as the dose metric in environmental toxicology. The key findings of the workshop are presented, along with recommendations for research to enhance understanding of toxic responses within and between species, and to advance the use of the TRA in assessment and management of chemicals in the environment. Integr Environ Assess Manag 2011;7:2–6. © 2010 SETAC

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