• 1
    Horvath, G. L., J. E. Schrum, C. M. De Nardo, and E. Latz. 2011. Intracellular sensing of microbes and danger signals by the inflammasomes. Immunol. Rev. 243(1):119135.
  • 2
    Dinarello, C. A. 2011. A clinical perspective of IL-1β as the gatekeeper of inflammation. Eur. J. Immunol. 41(5):12031217.
  • 3
    Van der Poll, T., and S. M. Opal. 2008. Host-pathogen interactions in sepsis. Lancet Infect Dis. 8(1):3243.
  • 4
    Fahy, R. J., M. C. Exline, M. A. Gavrilin, N. Y. Bhatt, B. Y. Besecker, A. Sarkar, J. L. Hollyfield, M. D. Duncan, H. N. Nagaraja, N. L. Knatz, et al., 2008. Inflammasome mRNA expression in human monocytes during early septic shock. Am. J. Respir. Crit. Care Med. 77(9):983988.
  • 5
    Scott, A. M., and M. Saleh. 2007. The inflammatory caspases: guardians against infections and sepsis. Cell Death Differ. 14(1):2331.
  • 6
    Cinel, I., and S. M. Opal. 2009. Molecular biology of inflammation and sepsis: a primer. Crit. Care Med. 37(1):291304.
  • 7
    Giamarellos-Bourboulis, E. J., F. L. van de Veerdonk, M. Mouktaroudi, M. Raftogiannis, A. Antonopoulou, L. A. B. Joosten, P. Pickkers, A. Sawa, M. Georgitsi, J. W. Van der Meer, et al. 2011. Inhibition of caspase-1 activation in Gram-negative sepsis and experimental endotoxemia. Crit. Care. 15(1):R27.
  • 8
    Bouchier-Hayes, L., H. Conroy, H. Egan, C. Adrain, E. M. Creagh, M. MacFarlane, S. J. Martin, et al. 2001. CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways. J. Biol. Chem. 276(47):4406944077.
  • 9
    Razmara, M., S. M. Srinivasula, L. Wang, J.-L. Poyet, B. J. Geddes, P. S. DiStefano, J. Bertin, E. S. Alnemri. 2002. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J. Biol. Chem. 277(16):1395213958.
  • 10
    Pathan, N. H. Marusawa, M. Krajewska, S. Matsuzawa, H. Kim, K. Okada, S. Torii, S. Kitada, S. Krajewski, K. Welsh, et al. 2001. TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer. J. Biol. Chem. 276(34):3222032229.
  • 11
    Ko, D. C., K. P. Shukla, C. Fong, M. Wasnick, M. J. Brittnacher, M. M. Wurfel, T. D. Holden, G. E. O'Keefe, B. Van Yserloo, J. M. Akey, et al. 2009. A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease. Am. J. Hum. Genet. 85(2):214227.
  • 12
    Verma, D., M. Lerm, R. Blomgran Julinder, P. Eriksson, P. Söderkvist, and E. Särndahl. 2008. Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases? Arthritis Rheum. 58(3):888894.
  • 13
    Blomgran, R., V. Patcha Brodin D. Verma, I. Bergström, P. Söderkvist, C. Sjöwall, P. Eriksson, M. Lerm, O. Stendahl, and E. Särndahl. 2012. Common genetic variations in the NALP3 inflammasome are associated with delayed apoptosis of human neutrophils. PLoS ONE. 7(3):e31326.
  • 14
    Pontillo, A., L. Brandao, R. Guimaraes, L. Segat, J. Araujo, and S. Crovella. 2010. Two SNPs in NLRP3 gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil. Autoimmunity. 43(8):583589.
  • 15
    Pontillo, A., A. Vendramin, E. Catamo, A. Fabris, and S. Crovella. 2011. The missense variation Q705K in CIAS1/NALP3/NLRP3 gene and an NLRP1 haplotype are associated with celiac disease. Am. J. Gastroenterol. 106(3):539544.
  • 16
    Roberts, R. L., R. K. G. Topless, A. J. Phipps-Green, R. B. Gearry, M. L. Barclay, and T. R. Merriman. 2010. Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease. Genes Immun. 11(4):351356.
  • 17
    Schoultz, I., D. Verma, J. Halfvarsson, L. Törkvist, M. Fredrikson, U. Sjöqvist, M. Lördal, C. Tysk, M. Lerm, P. Söderkvist, et al. 2009. Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men. Am. J. Gastroenterol. 104(5):11801188.
  • 18
    Kastbom, A., M. Johansson, D. Verma, P. Söderkvist, and S. Rantapää-Dahlqvist. 2010. CAR D8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis. Ann. Rheum. Dis. 69(4):723726.
  • 19
    Kastbom, A., D. Verma, P. Eriksson, T. Skogh, G. Wingren, and P. Söderkvist. 2008. Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project). Rheumatology (Oxford). 47(4):415417.
  • 20
    Verma, D., E. Särndahl, H. Andersson, P. Eriksson, M. Fredrikson, J.-I. Jönsson, M. Lerm, and P. Söderkvist. 2012. The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1β and IL-18 production. PLoS ONE. 7(4):e34977.
  • 21
    Sahdo, B., K. Fransén, B. Asfaw Idosa P. Eriksson, B. Söderquist, A. Kelly, and E. Söderquist. 2013. Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome. PLoS ONE. 8(10):e75457.
  • 22
    Rodriguez, S., T. R. Gaunt, and I. N. M. Day. 2009. Hardy–Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am. J. Epidemiol. 169(4):505514.
  • 23
    Paramel, G. V., L. Folkersen, R. J. Strawbridge, A. A. Elmabsout, E. Särndahl, P. Lundman, J. H. Jansson, G. K. Hansson, A. Sirsjö, and K. Fransén. 2013. CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation. Clin. Sci. 125(8):401407.
  • 24
    Mathiak, G., G. Grass, T. Herzmann, T. Luebke, C. C. Zetina, S. A. Boehm, H. Bohlen, L. F. Neville, and A. H. Hoelscher. 2000. Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses. Br. J. Pharmacol. 131(3):383386.
  • 25
    Boost, K. A., S. Hoegl, C. Hofstetter, M. Flondor, K. Stegewerth, I. Platacis, J. Pfeilschifter, H. Muhl, and B. Zwissler. 2007. Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia. Intensive Care Med. 33(5):863871.
  • 26
    Sarkar, A., M. W. Hall, M. Exline, J. Hart, N. Knatz, N. T. Gatson, and M. D. Wewers. 2006. Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18. Am. J. Respir. Crit. Care Med. 174(9):10031010.
  • 27
    Li, P. H. Allen, S. Banerjee, S. Franklin, L. Herzog, C. Johnston, J. McDowell, M. Paskind, L. Rodman, J. Salfeld, et al. 1995. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell. 80(3):401411.
  • 28
    Agard, N. J., D. Maltby, and J. A. Wells. 2010. Inflammatory stimuli regulate caspase substrate profiles. Mol Cell Proteomics. 9(5):880893.
  • 29
    Miao, E. A., I. A. Leaf, P. M. Treuting, D. P. Mao, M. Dors, A. Sarkar, S. E. Warren, M. D. Wewers, and A. Aderem. 2010. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat. Immunol. 11(12):11361142.
  • 30
    Tsuji, N. M., H. Tsutsui, E. Seki, K. Kuida, H. Okamura, K. Nakanishi, and R. A. Flavell. 2004. Roles of caspase-1 in Listeria infection in mice. Int. Immunol. 16(2):335343.
  • 31
    Lara-Tejero, M., F. S. Sutterwala, Y. Ogura, E. P. Grant, J. Bertin, A. J. Coyle, R. A. Flavell, and J. E. Galàn, 2006. Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J. Exp. Med. 203(6):14071412.
  • 32
    Mariathasan, S., D. S. Weiss, V. M. Dixit, and D. M. Monack. 2005. Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. J. Exp. Med. 202(8):10431049.
  • 33
    Fontalba, A., O. Gutiérrez, J. Llorca, I. Mateo, J. Berciano, J. L. Fernández-Luna, and O. Combarros. 2008. Deficiency of CARD8 is associated with increased Alzheimer's disease risk in women. Dement Geriatr. Cogn. Disord. 26(3):247250.
  • 34
    Fontalba, A., V. Martinez-Taboada, O. Gutierrez, C. Pipaon, N. Benito, A. Balsa, R. Blanco, and J. L. Fernandez-Luna. 2007. Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity. J. Immunol. 179(7):48674873.