Human T cells expressing BEND3 on their surface represent a novel subpopulation that preferentially produces IL-6 and IL-8 (pages 35–43)
Hirokazu Shiheido, Koji Kitagori, Chiyomi Sasaki, Shio Kobayashi, Takane Aoyama, Kozue Urata, Takuma Oku, Yoshitaka Hirayama, Hiroyuki Yoshitomi, Masaki Hikida, Hajime Yoshifuji, Tsuneyo Mimori, Takeshi Watanabe and Jun Shimizu
Article first published online: 19 FEB 2014 | DOI: 10.1002/iid3.17
BEND3 was previously shown to be involved in chromatin function and transcription. However, we demonstrated here that approximately 3% of human T cells expressed BEND3 on their cell surface (referred to as BEND3+ T cells). The stimulation of BEND3+ T cells through the TCR/CD3 complex resulted in the production of various kinds of cytokines, and in the markedly higher production of IL-6 and IL-8 than that by BEND3− T cells.