Immunity, Inflammation and Disease

Cover image for Vol. 2 Issue 1

June 2014

Volume 2, Issue 1

Pages i–iii, 1–61

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Original Research
    1. You have full text access to this OnlineOpen article
      Issue Information (pages i–iii)

      Article first published online: 6 JUN 2014 | DOI: 10.1002/iid3.10

  2. Original Research

    1. Top of page
    2. Issue Information
    3. Original Research
    1. You have full text access to this OnlineOpen article
      Endogenous cathelicidin production limits inflammation and protective immunity to Mycobacterium avium in mice (pages 1–12)

      José Carlos Santos, Sandro Silva-Gomes, João Pedro Silva, Miguel Gama, Gustavo Rosa, Richard L. Gallo and Rui Appelberg

      Article first published online: 31 OCT 2013 | DOI: 10.1002/iid3.7

      Thumbnail image of graphical abstract

      Cathelicidin-derived peptides have been shown to participate in anti-mycobacterial effector mechanisms. Here we show that cathelicidins are induced in macrophages by Mycobacterium avium but are not required for the control of these mycobacteria. In vivo, cathelicidin-deficient mice are slightly more resistant to infection and show an enhanced immune response to the mycobacteria.

    2. You have full text access to this OnlineOpen article
      C10X polymorphism in the CARD8 gene is associated with bacteraemia (pages 13–20)

      Berhane Asfaw Idosa, Berolla Sahdo, Ermias Balcha, Anne Kelly, Bo Söderquist and Eva Särndahl

      Article first published online: 5 NOV 2013 | DOI: 10.1002/iid3.14

      Thumbnail image of graphical abstract

      The polymorphism C10X in the CARD8 gene was significantly more prevalent in patients with bacteraemia compared to healthy individuals, whereas patients with negative blood culture, that is patients that exhibit severe diseases without detectable bacteraemia, displayed similar expression of C10X as healthy individuals. The patients were susceptible to infections caused by Gram-positive as well as Gram-negative bacteria.

    3. You have full text access to this OnlineOpen article
      The role of neutrophils and G-CSF in DNFB-induced contact hypersensitivity in mice (pages 21–34)

      Anne Deen Christensen, Søren Skov and Claus Haase

      Article first published online: 3 JAN 2014 | DOI: 10.1002/iid3.16

      Thumbnail image of graphical abstract

      This article supports that neutrophils are important drivers of the inflammation in the DNFB-induced CHS model and shows that G-CSF is a significant factor in mobilizing neutrophils during the response

    4. You have full text access to this OnlineOpen article
      Human T cells expressing BEND3 on their surface represent a novel subpopulation that preferentially produces IL-6 and IL-8 (pages 35–43)

      Hirokazu Shiheido, Koji Kitagori, Chiyomi Sasaki, Shio Kobayashi, Takane Aoyama, Kozue Urata, Takuma Oku, Yoshitaka Hirayama, Hiroyuki Yoshitomi, Masaki Hikida, Hajime Yoshifuji, Tsuneyo Mimori, Takeshi Watanabe and Jun Shimizu

      Article first published online: 19 FEB 2014 | DOI: 10.1002/iid3.17

      Thumbnail image of graphical abstract

      BEND3 was previously shown to be involved in chromatin function and transcription. However, we demonstrated here that approximately 3% of human T cells expressed BEND3 on their cell surface (referred to as BEND3+ T cells). The stimulation of BEND3+ T cells through the TCR/CD3 complex resulted in the production of various kinds of cytokines, and in the markedly higher production of IL-6 and IL-8 than that by BEND3 T cells.

    5. You have full text access to this OnlineOpen article
      The effects of thymic stromal lymphopoietin and IL-3 on human eosinophil–basophil lineage commitment: Relevance to atopic sensitization (pages 44–55)

      Claudia C. K. Hui, Sina Rusta-Sallehy, Ilan Asher, Delia Heroux and Judah A. Denburg

      Article first published online: 9 MAY 2014 | DOI: 10.1002/iid3.20

      Thumbnail image of graphical abstract

      This study demonstrates that TSLP and IL-3-induced Eo/B differentiation is heterogeneous and associated with atopy. TSLP and IL-3 may influence the development of allergic disease by regulating Eo/B differentiation through induction of autocrine TNFα secretion by CD34+ progenitors.

    6. You have full text access to this OnlineOpen article
      Gamma delta T cells in non-immune patients during primary schistosomal infection (pages 56–61)

      Eli Schwartz, Etti Rosenthal and Ilan Bank

      Article first published online: 16 MAY 2014 | DOI: 10.1002/iid3.18

      Thumbnail image of graphical abstract

      Acute schistosomiasis (Katayama Fever) occurs in a subset of travelers infected with S. hematobium or S. mansoni. Here we show that a larger relative expansion of gamma delta T cells among the peripheral blood T cells is associated with protection from this clinical syndrome.

SEARCH

SEARCH BY CITATION