Immunity, Inflammation and Disease

Cover image for Vol. 2 Issue 2

August 2014

Volume 2, Issue 2

Pages i–iii, 63–130

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Original Research
    1. You have full text access to this OnlineOpen article
      Issue Information (pages i–iii)

      Version of Record online: 26 JUL 2014 | DOI: 10.1002/iid3.11

       

  2. Original Research

    1. Top of page
    2. Issue Information
    3. Original Research
    1. You have full text access to this OnlineOpen article
      HPV associated tumor cells control tumor microenvironment and leukocytosis in experimental models (pages 63–75)

      Simone Cardozo Stone, Renata Ariza Marques Rossetti, Aleida Maria Lima and Ana Paula Lepique

      Version of Record online: 18 MAY 2014 | DOI: 10.1002/iid3.21

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      Human Papillomavirus (HPV) infection is the main etiological factor for cervical cancer and other anogenital tumors. Comparing HPV positive and negative cervical cancer derived cell lines, we showed that HPV controls local inflammation and proliferation of myeloid cells in lymphoid organs, and are significantly more efficient in recruiting these cells to the tumor microenvironment, than HPV negative tumors. Our work gathers information on mechanisms by which HPV regulates inflammation and may be useful for therapy design.

    2. You have full text access to this OnlineOpen article
      A pilot study showing differences in glycosylation patterns of IgG subclasses induced by pneumococcal, meningococcal, and two types of influenza vaccines (pages 76–91)

      Anne Cathrine Vestrheim, Anders Moen, Wolfgang Egge-Jacobsen, Leon Reubsaet, Trine Grønhaug Halvorsen, Diane Bryant Bratlie, Berit Smestad Paulsen and Terje Einar Michaelsen

      Version of Record online: 22 MAY 2014 | DOI: 10.1002/iid3.22

      Thumbnail image of graphical abstract

      The glycosylation patterns of the carbohydrate moiety situated at asparagine 297 on the Fc portion of human IgG following immunization have been studied. Blood was collected at different time points following vaccination, and different vaccine antigens and formulations were used. Differences in glycosylation patterns were found; both between different vaccine antigens and vaccine formulations, but also from antibodies collected at different time points and between individuals.

    3. You have full text access to this OnlineOpen article
      A novel and well tolerated mite allergoid subcutaneous immunotherapy: evidence of clinical and immunologic efficacy (pages 92–98)

      Albert Roger, Nathalie Depreux, Yani Jurgens, Matthew D. Heath, Gloria Garcia and Murray A. Skinner

      Version of Record online: 29 MAY 2014 | DOI: 10.1002/iid3.23

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      A novel, tyrosine-adsorbed, modified mite allergen product, Acarovac Plus, seeks to address the underlying cause of allergic rhinitis in this instance. The study compares the efficacy and safety of this subcutaneous immunotherapy, administered under a Conventional and Clustered dosing schedule. Cluster and conventional specific immunotherapy resulted in no adverse reaction(s) and led to improvements in immunological parameters, clinical efficacy (Nasal Challenge Test) and high overall satisfaction.

    4. You have full text access to this OnlineOpen article
      Eosinophils in the blood of hematopoietic stem cell transplanted patients are activated and have different molecular marker profiles in acute and chronic graft-versus-host disease (pages 99–113)

      Julia Cromvik, Marianne Johnsson, Krista Vaht, Jan-Erik Johansson and Christine Wennerås

      Version of Record online: 6 JUL 2014 | DOI: 10.1002/iid3.25

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      The eosinophilic granulocytes in blood from hematopoietic stem cell transplanted patients with graft-versus-host disease are activated. These eosinophils have different molecular marker profiles in acute and chronic graft-versus-host disease.

    5. You have full text access to this OnlineOpen article
      Skin prick test reactivity to lupin in comparison to peanut, pea, and soybean in atopic and non-atopic German subjects: A preliminary cross-sectional study (pages 114–120)

      Melanie Bähr, Anita Fechner, Martin Kaatz and Gerhard Jahreis

      Version of Record online: 3 JUN 2014 | DOI: 10.1002/iid3.24

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      The objective was to evaluate the prevalence of sensitization to lupin in comparison to that of other legumes (pea, peanut, and soybean) in 81 atopic and 102 non-atopic adults. The prevalence rates of lupin sensitization were comparable to or even lower than those of pea, peanut, and soybean. There is a clear risk of a lupin sensitization in predisposed subjects.

    6. You have full text access to this OnlineOpen article
      Myeloid suppressor cells require membrane TNFR2 expression for suppressive activity (pages 121–130)

      Johannes Polz, Annika Remke, Sabine Weber, Dominic Schmidt, Dorothea Weber-Steffens, Anne Pietryga-Krieger, Nils Müller, Uwe Ritter, Sven Mostböck and Daniela N. Männel

      Version of Record online: 28 MAY 2014 | DOI: 10.1002/iid3.19

      Thumbnail image of graphical abstract

      TNF and TNF receptor type 2 (TNFR2) have been shown to be important for generation of myeloid-derived suppressor cells (MDSC). Using TNFR2-deficient mice membrane TNFR2 expression on myeloid cells was found to be critical for generation and function of monocytic MDSC.

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