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iid39-sm-0001-SuppFig-S1.tif7886KFigure S1. Expression of iNOS in lung tissues of M. tuberculosis infected IL-1 deficient mice. Mice deficient for IL-1α, IL-1β, IL-1α plus IL-1β, IL-1R1 or wild-type C57Bl/6 mice were exposed to M. tuberculosis H37Rv as in Figure 2 and the expression of iNOS in lung tissue assessed by immunostaining on day 35 post-infection (Magnification 100×; representative sections of n = 5 mice per group are shown).
iid39-sm-0002-SuppFig-S2.tif589KFigure S2. Pulmonary levels of IL-17A in M. tuberculosis infected IL-1 deficient mice. IL-17A concentrations in lung homogenates of mice deficient for IL-1α, IL-1β, IL-1α plus IL-1β, or IL-1R1 and of wild-type mice were quantified by ELISA (Duoset R&D Systems) at 35 days after M. tuberculosis infection (left panel) or 56 days after M. tuberculosis infection (right panel). Results are expressed as mean ± SEM of cytokine levels reported to whole lungs, and are from n = 5 mice per group, except for two controls at day 56 (*P < 0.05; **P < 0.01; ***P < 0.001, as compared to wild-type controls).

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