Family history and the risk of stomach cancer death in Japan: Differences by age and gender†
Article first published online: 5 NOV 2001
Copyright © 2002 Wiley-Liss, Inc.
International Journal of Cancer
Volume 97, Issue 5, pages 688–694, 10 February 2002
How to Cite
Yatsuya, H., Toyoshima, H., Mizoue, T., Kondo, T., Tamakoshi, K., Hori, Y., Tokui, N., Hoshiyama, Y., Kikuchi, S., Sakata, K., Hayakawa, N., Tamakoshi, A., Ohno, Y. and Yoshimura, T. (2002), Family history and the risk of stomach cancer death in Japan: Differences by age and gender. Int. J. Cancer, 97: 688–694. doi: 10.1002/ijc.10101
Members of the JACC Study Group include the authors given above, as well as the investigators listed in the Appendices.
- Issue published online: 8 JAN 2002
- Article first published online: 5 NOV 2001
- Manuscript Accepted: 31 AUG 2001
- Manuscript Revised: 14 AUG 2001
- Manuscript Received: 17 MAY 2001
- Ministry of Education. Grant Numbers: 61010076, 62010074, 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102, 11181101, 12218237
- family history;
- stomach cancer;
- gender difference;
- cohort study;
- JACC study
Familial aggregation of stomach cancer has long been observed. The effect on disease risk of family history and its magnitude according to the type of affected relatives, however, is not well known. We conducted a prospective analysis using the JACC study (Japan Collaborative Cohort Study For Evaluation of Cancer Risk, sponsored by Monbusho) data. During the follow-up period, 662 stomach cancer deaths were documented. A positive history of stomach cancer in one or more first-degree relatives was associated with a significantly increased risk of death from the disease in both men (RR 1.60; 95% CI 1.11–2.31) and women (RR 2.47; 95% CI 1.50–4.06). In the subanalysis stratified by age, the association between positive family history and stomach cancer was stronger in the age group from 40–59 (RR 2.62; 95% CI 1.34–5.11 for men and RR 5.88; 95% CI 2.70–12.82 for women) than in the age group from 60–79 (RR 1.31; 95% CI 0.84–2.05 for men and RR 1.44; 95% CI 0.72–2.88 for women). In the age group from 40–59, men with father's history and women with mother's and sister's history of the disease had a significantly increased risk (RR 3.14; 95% CI 1.51–6.55, RR 10.46; 95% CI 4.54–24.12, RR 13.39; 95% CI 3.89–46.12, respectively). When 2 or more family members were affected, the increment in the risk was prominent especially in women (RR 9.45; 95% CI 4.46–20.05). These results suggest the existence of a certain subtype of stomach cancer that is inherited more often by women from one generation to the next in gender-influenced fashion. Any preventive strategy should take into account the degree of individual susceptibility. © 2001 Wiley-Liss, Inc.