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Predictive Markers and Cancer Genetics
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Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis
Article first published online: 7 FEB 2002
DOI: 10.1002/ijc.10202
Copyright © 2002 Wiley-Liss, Inc.
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How to Cite
Mouria, M., Gukovskaya, A. S., Jung, Y., Buechler, P., Hines, O. J., Reber, H. A. and Pandol, S. J. (2002), Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int. J. Cancer, 98: 761–769. doi: 10.1002/ijc.10202
Publication History
- Issue published online: 12 MAR 2002
- Article first published online: 7 FEB 2002
- Manuscript Accepted: 2 NOV 2001
- Manuscript Revised: 31 OCT 2001
- Manuscript Received: 14 SEP 2001
Funded by
- State of California Cancer Research Fund under Interagency Agreement #97-12013 (University of California, Davis contract #98-00924V with the Department of Health Services, Cancer Research Program
- Department of Veterans Affairs
- Andrew Barnes Family Foundation
- Ronald S. Hirshberg Pancreatic Cancer Research Foundation
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- 1, , , , , , , , , , A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells, Bioorganic & Medicinal Chemistry Letters, 2012, 22, 5, 2114
- 2, , Selective apoptotic effects of piceatannol and myricetin in human cancer cells, Journal of Applied Toxicology, 2012, 32, 7Direct Link:
- 3, , , , Synergistic and suppressive effects of dietary phenolic acids and other phytochemicals from cereal extracts on nuclear factor kappa B activity, Food Chemistry, 2012, 133, 3, 969
- 4, , , , , The flavonoid quercetin in disease prevention and therapy: Facts and fancies, Biochemical Pharmacology, 2012, 83, 1, 6
- 5, , , Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines, Nutrition Research, 2011, 31, 2, 77
- You have free access to this content6, , , , , , , , , Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells, Cancer Science, 2011, 102, 4Direct Link:
- 7, , , , , , , , Fast repair of DNA radicals in the earliest stage of carcinogenesis suppresses hallmarks of cancer, RSC Advances, 2011, 1, 9, 1610
- 8, , , , , , Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway, Cancer Letters, 2011, 308, 2, 181
- 9, , Quercetin-induced downregulation of phospholipase D1 inhibits proliferation and invasion in U87 glioma cells, Biochemical and Biophysical Research Communications, 2011, 412, 4, 710
- 10, , , , , , , , , Treatment of Ovarian Cancer Cells with Nutlin-3 and Resveratrol Combination Leads to Apoptosis via Caspase Activation, Journal of Medicinal Food, 2011, 14, 1-2, 46
- 11
- 12, , Advanced dynamic monitoring of cellular status using label-free and non-invasive cell-based sensing technology for the prediction of anticancer drug efficacy, Analytical and Bioanalytical Chemistry, 2010, 398, 6, 2505
- 13, , , , , , , , Anti-Pancreatic Cancer Effects of a Polar Extract From the Edible Sea Cucumber, Cucumaria frondosa, Pancreas, 2010, 39, 5, 646
- 14, , , Cellular Proliferation, Apoptosis and Angiogenesis: Molecular Targets for Nutritional Preemption of Cancer, Seminars in Oncology, 2010, 37, 3, 243
- 15, , , , Identification and quantification of the active component quercetin 3-O-rutinoside fromBarringtonia racemosa, targets mitochondrial apoptotic pathway in acute lymphoblastic leukemia, Journal of Asian Natural Products Research, 2010, 12, 8, 639
- 16, , , , , Quercetin Modulates NF-κ B and AP-1/JNK Pathways to Induce Cell Death in Human Hepatoma Cells, Nutrition and Cancer, 2010, 62, 3, 390
- 17, , , , Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals, Cancer and Metastasis Reviews, 2010, 29, 3, 405
- 18, , , , , Resveratrol enhances the sensitivity of cholangiocarcinoma to chemotherapeutic agents, Laboratory Investigation, 2010, 90, 9, 1325
- 19, , , , The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro, Journal of Biomedicine and Biotechnology, 2010, 2010, 1
- 20, , , , , , Alkyl isothiocyanates suppress epidermal growth factor receptor kinase activity but augment tyrosine kinase activity, Cancer Epidemiology, 2009, 33, 3-4, 288
- 21, , Cancer chemoprevention and mitochondria: Targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics/redox state, Molecular Nutrition & Food Research, 2009, 53, 1Direct Link:
- 22, , , , , , , , Combination Treatment with Resveratrol and Sulforaphane Induces Apoptosis in Human U251 Glioma Cells, Neurochemical Research, 2009, 35, 1, 152
- 23, , , , , , , Effects of resveratrol analogs on cell cycle progression, cell cycle associated proteins and 5fluoro-uracil sensitivity in human derived colon cancer cells, International Journal of Cancer, 2009, 124, 12Direct Link:
- 24, , , , , , , Quercetin Induces Oxidative Stress and Potentiates the Apoptotic Action of 2-Methoxyestradiol in Human Hepatoma Cells, Nutrition and Cancer, 2009, 61, 5, 735
- 25, , , , , , , , , , , , Quercetin inhibits lymphocyte activation and proliferation without inducing apoptosis in peripheral mononuclear cells, Leukemia Research, 2009, 33, 1, 140
- 26, Uptake of resveratrol and role of resveratrol-targeting protein, quinone reductase 2, in normally cultured human prostate cells, Asian Journal of Andrology, 2009, 11, 6, 653
- 27, , Anticarcinogenesis by dietary phytochemicals: Cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-κB and AP-1 in abnormal cancer cells, Food and Chemical Toxicology, 2008, 46, 4, 1257
- 28, , , , Biochanin A Inhibits Breast Cancer Tumor Growth in A Murine Xenograft Model, Pharmaceutical Research, 2008, 25, 9, 2158
- You have free access to this content29, Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways, Molecular Nutrition & Food Research, 2008, 52, 5Direct Link:
- 30, , , , Cancer chemoprevention: A radical perspective, Free Radical Biology and Medicine, 2008, 45, 2, 97
- 31, , Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives, Cancer Letters, 2008, 269, 2, 243
- 32, , , , , , , Combined Effects of Genistein, Quercetin, and Resveratrol in Human and 3T3-L1 Adipocytes, Journal of Medicinal Food, 2008, 11, 4, 773
- 33, , Effects of Apopotosis on Induction of Resveratrol in Human Lung Cancer A549 Cells, Journal of Life Science, 2008, 18, 5, 591
- 34, , , , , , , , , Effects of Phytoestrogen on Mitochondrial Structure and Function of Hippocampal CA1 Region of Ovariectomized Rats, Cellular and Molecular Neurobiology, 2008, 28, 6, 875
- 35, , , , , , , Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin, Life Sciences, 2008, 82, 19-20, 1032
- 36, , , , , Inhibition of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase by flavonoids: A quantitative structure-activity relationship study, IUBMB Life, 2008, 60, 12Direct Link:
- 37, , , , Molecular mechanisms of oxidative stress resistance induced by resveratrol: Specific and progressive induction of MnSOD, Biochemical and Biophysical Research Communications, 2008, 367, 2, 406
- 38, , , , , , Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation, Journal of Cellular Biochemistry, 2008, 105, 6Direct Link:
- 39, , Rapid and quantitative method for evaluating the personal therapeutic potential of cancer drugs, Analytical and Bioanalytical Chemistry, 2008, 391, 5, 1889
- 40, , , , , , , , Synthesis of a library of glycosylated flavonols, Tetrahedron Letters, 2008, 49, 51, 7243
- 41, , , , , The dietary antioxidants resveratrol and quercetin protect cells from exogenous pro-oxidative damage, Food and Chemical Toxicology, 2008, 46, 4, 1320
- 42, , , The Role of Nuclear Factor κB in Pancreatic Cancer and the Clinical Applications of Targeted Therapy, Pancreas, 2008, 36, 3, 225
- 43
- 44
- 45, , , , , , , , Capsaicin induced apoptosis of B16-F10 melanoma cells through down-regulation of Bcl-2, Food and Chemical Toxicology, 2007, 45, 5, 708
- 46, , , Differential Effects of Antioxidants on the In Vitro Invasion, Growth and Lung Metastasis of Murine Colon Cancer Cells, Biological & Pharmaceutical Bulletin, 2007, 30, 1, 200
- 47, , , , Effects of genistein on proliferation and cell cycle of salivary adenoid cystic carcinoma cells, Chinese Journal of Cancer Research, 2007, 19, 1, 64
- 48, Ins and outs of dietary phytochemicals in cancer chemoprevention, Biochemical Pharmacology, 2007, 74, 4, 533
- 49, , Anticancer activity of grape and grape skin extracts alone and combined with green tea infusions, Cancer Letters, 2006, 238, 2, 202
- 50, , , , , , , , , , , Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure–activity relationship studies reveal salient pharmacophore features, Bioorganic & Medicinal Chemistry, 2006, 14, 24, 8295
- 51, , , , , , , , , , , Cytotoxic and biochemical effects of 3,3′,4,4′,5,5′-hexahydroxystilbene, a novel resveratrol analog in HL-60 human promyelocytic leukemia cells, Experimental Hematology, 2006, 34, 10, 1377
- 52, , , , , , , , NAG-1 up-regulation mediated by EGR-1 and p53 is critical for quercetin-induced apoptosis in HCT116 colon carcinoma cells, Apoptosis, 2006, 12, 2, 411
- 53, , Potential synergism of natural products in the treatment of cancer, Phytotherapy Research, 2006, 20, 4Direct Link:
- 54, , , , , , , , , Preventive effect of oral administration of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum) against pulmonary metastasis of B16-BL6 mouse melanoma cells, Cancer Detection and Prevention, 2006, 30, 2, 174
- 55, , , , , , , Preventive Effects of Quercetin against Benzo[a]pyrene-Induced DNA Damages and Pulmonary Precancerous Pathologic Changes in Mice, Basic & Clinical Pharmacology & Toxicology, 2006, 98, 6Direct Link:
- 56, , , Reactive Oxygen Species Production Is Involved in Quercetin-Induced Apoptosis in Human Hepatoma Cells, Nutrition and Cancer, 2006, 55, 2, 201
- 57, , , , , , , , Resveratrol induces apoptotic cell death in rat H4IIE hepatoma cells but necrosis in C6 glioma cells, Toxicology, 2006, 225, 2-3, 173
- 58, Sublethal mitochondrial stress with an attendant stoichiometric augmentation of reactive oxygen species may precipitate many of the beneficial alterations in cellular physiology produced by caloric restriction, intermittent fasting, exercise and dietary phytonutrients: “Mitohormesis†for health and vitality, Medical Hypotheses, 2006, 66, 4, 832
- 59, , Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells, Cancer Letters, 2005, 218, 2, 141
- 60, , , , , , , Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma, Cancer Chemotherapy and Pharmacology, 2005, 56, 3, 271
- 61, Mitochondria: A novel target for the chemoprevention of cancer, Apoptosis, 2005, 10, 4, 687
- 62, , , , , Modulation of osteoclastogenesis in porcine bone marrow cultures by quercetin and rutin, Cell and Tissue Research, 2005, 319, 3, 383
- 63, , , , , , , , , Protective effect of Coptidis Rhizoma on S-nitroso-N-acetylpenicillamine (SNAP)-induced apoptosis and necrosis in pancreatic RINm5F cells, Life Sciences, 2005, 76, 8, 917
- 64, , Resveratrol as an anti-inflammatory and anti-aging agent: Mechanisms and clinical implications, Molecular Nutrition & Food Research, 2005, 49, 5Direct Link:
- 65, , , , , , , Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-κB, International Journal of Cancer, 2005, 115, 1Direct Link:
- 66, , , , Role of Inflammation in Pancreatic Carcinogenesis and the Implications for Future Therapy, Pancreatology, 2005, 5, 6, 514
- 67, , , , , , , , , , Synergistic action of resveratrol, an ingredient of wine, with Ara-C and tiazofurin in HL-60 human promyelocytic leukemia cells, Experimental Hematology, 2005, 33, 3, 329
- 68, , , , , , , , , Toxicogenomics of resveratrol in rat liver, Life Sciences, 2005, 76, 20, 2299
- 69
- 70
- 71
- 72, , , , , , Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression, Cancer, 2004, 100, 1Direct Link:
- 73, , Cell Death Pathways in Pancreatitis and Pancreatic Cancer, Pancreatology, 2004, 4, 6, 567
- 74, , , , , Differential sensitivity to resveratrol-induced apoptosis of human chronic myeloid (K562) and acute lymphoblastic (HSB-2) leukemia cells, Biochemical Pharmacology, 2004, 68, 10, 2019
- 75, , , , , , Inhibition of Neoplastic Transformation of Benzo[α]pyrene-Treated BALB/c 3T3 Murine Cells by a Phytochemical Extract of Passionfruit Juice, Journal of Medicinal Food, 2004, 7, 4, 402
- 76, , Molecular basis of chemoprevention by resveratrol: NF-κB and AP-1 as potential targets, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2004, 555, 1-2, 65
- 77, , Targeting signal transduction pathways by chemopreventive agents, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2004, 555, 1-2, 33
- 78, , , , , , , , The Combination of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (TRAIL/Apo2L) and Genistein Is Effective in Inhibiting Pancreatic Cancer Growth, Pancreas, 2004, 29, 1, 45
- 79, Transcription Factors in the Cellular Signaling Network as Prime Targets of Chemopreventive Phytochemicals, Cancer Research and Treatment, 2004, 36, 5, 275
- 80, , , Vitamins, Phytochemicals, Diets, and Their Implementation in Cancer Chemoprevention, Critical Reviews in Food Science and Nutrition, 2004, 44, 6, 437
- 81
- 82, , , , Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets, International Journal of Cancer, 2003, 104, 2Direct Link:
- 83, , , , , , , , Identification of 6-methylsulfinylhexyl isothiocyanate as an apoptosis-inducing component in wasabi, Phytochemistry, 2003, 62, 5, 733
- 84, Pancreatic cancer - a continuing challenge in oncology, Pathology & Oncology Research, 2003, 9, 4, 252
- 85, , , , , , , Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential, European Journal of Pharmacology, 2003, 459, 2-3, 255
- 86
- 87, , Resveratrol Inhibits Proliferation and Induces Apoptosis in Human Pancreatic Cancer Cells, Pancreas, 2002, 25, 4, e71