1097-0215/asset/cover.gif?v=1&s=9bea5e55449dab2cff7ad3b06277cc9745417a23 "International Journal of Cancer")
Fax: +310-268-4578
1097-0215/asset/olbannerleft.jpg?v=1&s=45719cd7de57873027993264fcc568b335a8cd56)
1097-0215/asset/olbannerright.jpg?v=1&s=5e0fba63c1309b3036eb9215a0e1e83dd02efd19)
Predictive Markers and Cancer Genetics
You have full text access to this OnlineOpen article
Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis
Article first published online: 7 FEB 2002
DOI: 10.1002/ijc.10202
Copyright © 2002 Wiley-Liss, Inc.
Additional Information
How to Cite
Mouria, M., Gukovskaya, A. S., Jung, Y., Buechler, P., Hines, O. J., Reber, H. A. and Pandol, S. J. (2002), Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int. J. Cancer, 98: 761–769. doi: 10.1002/ijc.10202
Publication History
- Issue published online: 12 MAR 2002
- Article first published online: 7 FEB 2002
- Manuscript Accepted: 2 NOV 2001
- Manuscript Revised: 31 OCT 2001
- Manuscript Received: 14 SEP 2001
Funded by
- State of California Cancer Research Fund under Interagency Agreement #97-12013 (University of California, Davis contract #98-00924V with the Department of Health Services, Cancer Research Program
- Department of Veterans Affairs
- Andrew Barnes Family Foundation
- Ronald S. Hirshberg Pancreatic Cancer Research Foundation
REFERENCES
- 1, , . AGA technical review on the epidemiology, diagnosis and treatment of pancreatic ductal adenocarcinoma: American Gastroenterological Association. Gastroenterology 1999;117: 1464–84.
- 2, , . Pancreatic adenocarcinoma. In: YamadaT, AlpersDH, LaineL, OwyangC, PowellDW, eds. Textbook of gastroenterology, 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 1999. 2178–92.
- 3, . 1991. Vegetables, fruit and cancer. I. Epidemiology. Cancer Causes Control 1991;2: 325–57.
- 4, , . Wine as a biological fluid: history, production and role in disease prevention. J Clin Lab Anal 1997;11: 287–313.Direct Link:
- 5. Polyphenols: chemistry, dietary sources, metabolism and nutritional significance. Nutr Rev 1998;56: 317–33.Direct Link:
- 6, , , et al. Diet and pancreatic cancer: a case-control study. Am J Epidemiol 1986;124: 894–902.
- 7, , , et al. Cancer chemopreventive activity of resveratrol, a natural product derived. Science 1997;275: 218–20.
- 8, , , et al. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J Biol Chem 1998;273: 21875–82.
- 9, , , et al. An improved clinical model of orthotopic pancreatic cancer in immunocompetent Lewis rats. Pancreas 2001;22: 113–21.
- 10, , , et al. Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus. Hum Gene Ther 2000;11: 223–35.
- 11, . Mitochondrial control of cell death. Nature Med 2000;6: 513–9.
- 12, , . Mitochondrial control of apoptosis: the role of cytochrome c. Biochim Biophys Acta 1998;1366: 139–49.
- 13. Apoptosis in the pathogenesis and treatment of disease. Science 1995;267: 1456–62.
- 14
- 15, . Caspases: intracellular signaling by proteolysis. Cell 1997;91: 443–6.
- 16. Cell suicide for beginners. Nature 1998;396: 119–22.
- 17. Apoptotic pathways: the roads to ruin. Cell 1998;94: 695–8.
- 18, , . The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 1995;81: 495–504.
- 19, , , et al. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 1996;84: 299–308.
- 20, , , et al. The death domain: a module shared by proteins with diverse cellular functions. Trends Biochem Sci 1995;20: 342–4.
- 21, . Mitochondria and apoptosis. Science 1998;281: 1309–12.
- 22, , , et al. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 1999;400: 886–91.
- 23. The mitochondrial permeability transition pore and its role in cell death. Biochem J 1999;341: 233–49.
- 24, , , et al. Recombinant human (rh) IL-4-mediated apoptosis and recombinant human IL-6-mediated protection of recombinant human stem cell factor-dependent human mast cells derived from cord blood mononuclear cell progenitors. J Immunol 1999;163: 5105–15.
- 25, , , et al. Suppression in TNF-alpha-induced apoptosis by NF-kappaB. Science 1996;274: 787–9.
- 26, , . TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 1996;274: 784–7.
- 27, , , et al. NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol 1999; 5923–9.
- 28, , , et al. The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene 1998; 3247–529.
- 29, , , et al. A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice. Oncogene 1999;18: 2579–88.
- 30. Permissivity for methorexate-induced DHFR gene amplification correlates with the metastatic potential or rat adenocarcinoma cells. Carcinogenesis 1994;15: 695–700.
- 31, , , et al. Pancreatic acinar cells produce, release and respond to tumor necrosis factor-α: Role in regulating cell death and pancreatitis. Clin Invest 1997;100: 1853–62.
- 32, , , et al. Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat. Gastroenterology 1996;110: 875–84.
- 33, , , et al. The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis. Gastroenterology 1996;111: 1081–91.
- 34, , , et al. The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J Biol Chem 1998;273: 7770–5.
- 35, , , et al. Early NF-κB activation is associated with hormone-induced pancreatitis. Am J Physiol 1998;275: G1402–14.
- 36, , , et al. Ethanol diet increases the sensitivity of the rats to pancreatitis induced by cholecystoknin octapeptide. Gastroenterology 1999;117: 706–16.
- 37, , , et al. Activation of pancreatic acinar cells upon isolation from tissue: upregulation of cytokines via p38 MAP kinase. Am J Physiol 2000;C 1993–2003.
- 38, , , et al. Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468. Cancer Res 1994;54: 2424–8.
- 39, , , et al. Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin. Biochem Biophys Res Commun 1983;117: 444–7.
- 40, , . Quercetin inhibits tyrosine phosphorylation by the cyclic nucleotide-independent, transforming protein kinase, pp60src. Naunyn Schmiedebergs Arch Pharmacol 1981;317: 100–2.
- 41, , . The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs. Biochem Biophys Res Commun 1992;186: 624–31.
- 42, , , et al. Distinct Chk2 activation pathways are triggered by genistein and DNA-damaging agents in human melanoma cells. J Biol Chem 2000;275: 15363–9.
- 43, , , et al. Flavonoids and the inhibition of PKC and PI 3-kinase. Gen Pharmacol 1999;32: 279–86.
- 44, , , et al. Reservatrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells. Cancer Lett 1999;140: 1–10.
- 45, . Differential effects on growth, cell cycle arrest and induction of apoptosis by reservatrol in human prostrate cancer cell lines. Exp Cell Res 1999;249: 109–15.
- 46, , , et al. Resveratrol suppresses all transformation and induces apoptosis through a p53 dependent pathway. Carcinogenesis 1999;20: 237–42.
- 47, , , et al. Involvemant of capsase-3 in epigallocalechin-3-gallate-mediated apoptosis on human chondrosarcoma cells. Biochem Biophys Res Commun 2000;270: 793–7.
- 48, , , et al. Inducrion of apoptosis by flavones, falvonols (3-hydroxyflavones) and isoprenoid substituted flavonoids in human oral tumor cell lines. Anticancer Res 2000;20: 271–7.
- 49, , , et al. Growth inhibition, cell-cycle dysregulation and induction of apoptosis by green tea constituent (−)-epigallocatechin-3-gallate in androgen-sensitive and androgen-insensitive human prostate carcinoma cells. Toxicol Appl Pharmacol 2000;164: 82–90.
- 50, , , et al. Green tea polyphenols induce apoptosis in vitro in peripheral blood T lymphocytes of adult T-cell leukemia patients. Jpn J Cancer Res 2000;91: 34–40.
- 51, , . Induction of apoptosis in prostate cancer cell lines by the green tea component, (−)-epigallocatechin-3-gallate. Cancer Lett 1998;130: 1–7.
- 52, , . Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 1999;35: 1517–25.
- 53, , . Green tea polyphenol epigallocatechin-3-gallate differentially moduates nucleur factor kappaB in cancer cells versus normal cells. Arch Biochem Biophys 2000;376: 338–46.
- 54, , . Suppression of nitricoxide synthase and down-regulation of the activation of NFkappaB in macrophages by resveratrol. Br J Pharmacol 1999;126: 673–80.Direct Link:
- 55. Polyphenols: chemistry, dietary sources, metabolism and nutritional significance. Nutr Rev 1998;56: 317–33.Direct Link:
- 56, . NF-kappaB/rel/IkappaB: implications in gastrointestinal diseases. Gastroenterology 2000;118: 1208–28.