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p53 status correlates with the differential expression of the DNA mismatch repair protein MSH2 in non-small cell lung carcinoma
Article first published online: 1 AUG 2002
Copyright © 2002 Wiley-Liss, Inc.
International Journal of Cancer
Volume 101, Issue 3, pages 248–252, 20 September 2002
How to Cite
Xinarianos, G., Liloglou, T., Prime, W., Sourvinos, G., Karachristos, A., Gosney, J. R., Spandidos, D. A. and Field, J. K. (2002), p53 status correlates with the differential expression of the DNA mismatch repair protein MSH2 in non-small cell lung carcinoma. Int. J. Cancer, 101: 248–252. doi: 10.1002/ijc.10598
- Issue published online: 20 AUG 2002
- Article first published online: 1 AUG 2002
- Manuscript Accepted: 3 JUN 2002
- Manuscript Revised: 12 APR 2002
- Manuscript Received: 10 DEC 2001
- Roy Castle Lung Cancer Foundation
- non-small cell lung carcinoma
We examined the p53 status of 108 NSCLCs compared to the expression of MLH1 and MSH2 proteins. p53 overexpression was demonstrated by IHC in 64% of patients examined, whereas p53 mutations were detected in 43%. Twenty-two percent of mutations were located outside of the hot-spot (exons 5–8) area. p53 mutations and overexpression were more frequent in SCCL (57% and 73%, respectively) than in lung adenocarcinomas (22% and 50%, respectively). In NSCLC-carrying wild-type p53, increased expression of MSH2 correlated with p53 overexpression (p = 0.018). In addition, in SCCL, p53 mutations correlated with reduced MSH2 expression (p = 0.019). These data suggest a relationship between p53 and MSH2. While there is evidence for p53 being a transcriptional activator of MSH2, the hypothesis that MSH2 acts as a DNA-damage signaller triggering p53 overexpression needs to be clarified in future studies. © 2002 Wiley-Liss, Inc.