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Epidemiology
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Oesophageal adenocarcinoma: A paradigm of mechanical carcinogenesis?
Article first published online: 17 SEP 2002
DOI: 10.1002/ijc.10697
Copyright © 2002 Wiley-Liss, Inc.
Additional Information
How to Cite
La Vecchia, C., Negri, E., Lagiou, P. and Trichopoulos, D. (2002), Oesophageal adenocarcinoma: A paradigm of mechanical carcinogenesis?. International Journal of Cancer, 102: 269–270. doi: 10.1002/ijc.10697
Publication History
- Issue published online: 22 OCT 2002
- Article first published online: 17 SEP 2002
- Manuscript Accepted: 29 JUL 2002
- Manuscript Revised: 22 JUL 2002
- Manuscript Received: 7 MAY 2002
Funded by
- Italian Association for Cancer Research
- Italian League Against Cancer
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- Cited By
Keywords:
- oesophageal adenocarcinoma;
- carcinogenesis;
- risk
Abstract
Incidence of adenocarcinoma of the oesophagus and gastric cardia is increasing in most developed countries and strongly associated with obesity and male gender. An underlying increase in the prevalence of gastro-oesophageal reflux has generally been postulated. We suggest that the increase in frequency of reflux and the 2 associated forms of cancer can be explained by growing abdominal pressure brought about by increasing central obesity, most common among men, and sedentary lifestyle, including car use. Abdominal pressure is further accentuated mainly in men by the shift in Western male dressing towards the general use of belts. © 2002 Wiley-Liss, Inc.